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CAPN15 calpain 15 [ Homo sapiens (human) ]

Gene ID: 6650, updated on 18-Nov-2018

Summary

Official Symbol
CAPN15provided by HGNC
Official Full Name
calpain 15provided by HGNC
Primary source
HGNC:HGNC:11182
See related
Ensembl:ENSG00000103326 MIM:603267; Vega:OTTHUMG00000119059
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SOLH
Summary
This gene encodes a protein containing zinc-finger-like repeats and a calpain-like protease domain. The encoded protein may function as a transcription factor, RNA-binding protein, or in protein-protein interactions during visual system development. [provided by RefSeq, Jul 2008]
Expression
Broad expression in colon (RPKM 5.1), spleen (RPKM 4.7) and 25 other tissues See more
Orthologs

Genomic context

See CAPN15 in Genome Data Viewer
Location:
16p13.3
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (527794..554636)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (577816..604636)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene RAB11 family interacting protein 3 Neighboring gene long intergenic non-protein coding RNA 235 Neighboring gene microRNA 5587 Neighboring gene microRNA 3176 Neighboring gene uncharacterized LOC107987233 Neighboring gene proline rich 35 Neighboring gene NHL repeat containing 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Phenotypes

NHGRI GWAS Catalog

Description
GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children.
NHGRI GWA Catalog

Pathways from BioSystems

  • Degradation of the extracellular matrix, organism-specific biosystem (from REACTOME)
    Degradation of the extracellular matrix, organism-specific biosystemMatrix metalloproteinases (MMPs), previously referred to as matrixins because of their role in degradation of the extracellular matrix (ECM), are zinc and calcium dependent proteases belonging to the...
  • Extracellular matrix organization, organism-specific biosystem (from REACTOME)
    Extracellular matrix organization, organism-specific biosystemThe extracellular matrix is a component of all mammalian tissues, a network consisting largely of the fibrous proteins collagen, elastin and associated-microfibrils, fibronectin and laminins embedded...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC131491

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium-dependent cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
calpain-15
Names
small optic lobes homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005632.2NP_005623.1  calpain-15

    See identical proteins and their annotated locations for NP_005623.1

    Status: REVIEWED

    Source sequence(s)
    BC044259, BX341589, U69557, U85647
    Consensus CDS
    CCDS10410.1
    UniProtKB/Swiss-Prot
    O75808
    Related
    ENSP00000219611.2, OTTHUMP00000147599, ENST00000219611.6, OTTHUMT00000239271
    Conserved Domains (5) summary
    smart00547
    Location:529
    ZnF_RBZ; Zinc finger domain
    cd00044
    Location:476791
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
    sd00025
    Location:147166
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    sd00029
    Location:344363
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:412438
    zf-RanBP; Zn-finger in Ran binding protein and others

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    527794..554636
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522628.3XP_011520930.1  calpain-15 isoform X4

    See identical proteins and their annotated locations for XP_011520930.1

    Conserved Domains (5) summary
    smart00547
    Location:529
    ZnF_RBZ; Zinc finger domain
    cd00044
    Location:476791
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
    sd00025
    Location:147166
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    sd00029
    Location:344363
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:412438
    zf-RanBP; Zn-finger in Ran binding protein and others
  2. XM_011522629.3XP_011520931.1  calpain-15 isoform X4

    See identical proteins and their annotated locations for XP_011520931.1

    Conserved Domains (5) summary
    smart00547
    Location:529
    ZnF_RBZ; Zinc finger domain
    cd00044
    Location:476791
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
    sd00025
    Location:147166
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    sd00029
    Location:344363
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:412438
    zf-RanBP; Zn-finger in Ran binding protein and others
  3. XM_011522627.2XP_011520929.1  calpain-15 isoform X3

    Conserved Domains (5) summary
    smart00547
    Location:7397
    ZnF_RBZ; Zinc finger domain
    cd00044
    Location:544859
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
    sd00025
    Location:169191
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    sd00029
    Location:412431
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:480506
    zf-RanBP; Zn-finger in Ran binding protein and others
  4. XM_017023596.1XP_016879085.1  calpain-15 isoform X1

    Conserved Domains (4) summary
    smart00547
    Location:7397
    ZnF_RBZ; Zinc finger domain
    cd00044
    Location:544859
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
    sd00025
    Location:169191
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    sd00029
    Location:412431
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
  5. XM_011522623.2XP_011520925.1  calpain-15 isoform X1

    See identical proteins and their annotated locations for XP_011520925.1

    Conserved Domains (4) summary
    smart00547
    Location:7397
    ZnF_RBZ; Zinc finger domain
    cd00044
    Location:544859
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
    sd00025
    Location:169191
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    sd00029
    Location:412431
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
  6. XM_011522620.2XP_011520922.1  calpain-15 isoform X1

    See identical proteins and their annotated locations for XP_011520922.1

    Conserved Domains (4) summary
    smart00547
    Location:7397
    ZnF_RBZ; Zinc finger domain
    cd00044
    Location:544859
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
    sd00025
    Location:169191
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    sd00029
    Location:412431
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
  7. XM_011522624.2XP_011520926.1  calpain-15 isoform X1

    See identical proteins and their annotated locations for XP_011520926.1

    Conserved Domains (4) summary
    smart00547
    Location:7397
    ZnF_RBZ; Zinc finger domain
    cd00044
    Location:544859
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
    sd00025
    Location:169191
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    sd00029
    Location:412431
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
  8. XM_011522630.2XP_011520932.1  calpain-15 isoform X4

    See identical proteins and their annotated locations for XP_011520932.1

    Conserved Domains (5) summary
    smart00547
    Location:529
    ZnF_RBZ; Zinc finger domain
    cd00044
    Location:476791
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
    sd00025
    Location:147166
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    sd00029
    Location:344363
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:412438
    zf-RanBP; Zn-finger in Ran binding protein and others
  9. XM_011522625.2XP_011520927.1  calpain-15 isoform X1

    See identical proteins and their annotated locations for XP_011520927.1

    Conserved Domains (4) summary
    smart00547
    Location:7397
    ZnF_RBZ; Zinc finger domain
    cd00044
    Location:544859
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
    sd00025
    Location:169191
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    sd00029
    Location:412431
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
  10. XM_011522631.2XP_011520933.1  calpain-15 isoform X4

    See identical proteins and their annotated locations for XP_011520933.1

    Conserved Domains (5) summary
    smart00547
    Location:529
    ZnF_RBZ; Zinc finger domain
    cd00044
    Location:476791
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
    sd00025
    Location:147166
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    sd00029
    Location:344363
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:412438
    zf-RanBP; Zn-finger in Ran binding protein and others
  11. XM_011522626.3XP_011520928.1  calpain-15 isoform X2

    Conserved Domains (4) summary
    smart00547
    Location:7397
    ZnF_RBZ; Zinc finger domain
    cd00044
    Location:544859
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
    sd00025
    Location:169191
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    sd00029
    Location:412431
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
  12. XM_011522621.2XP_011520923.1  calpain-15 isoform X1

    See identical proteins and their annotated locations for XP_011520923.1

    Conserved Domains (4) summary
    smart00547
    Location:7397
    ZnF_RBZ; Zinc finger domain
    cd00044
    Location:544859
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
    sd00025
    Location:169191
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    sd00029
    Location:412431
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
  13. XM_011522632.2XP_011520934.1  calpain-15 isoform X4

    See identical proteins and their annotated locations for XP_011520934.1

    Conserved Domains (5) summary
    smart00547
    Location:529
    ZnF_RBZ; Zinc finger domain
    cd00044
    Location:476791
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
    sd00025
    Location:147166
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    sd00029
    Location:344363
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:412438
    zf-RanBP; Zn-finger in Ran binding protein and others
  14. XM_011522622.1XP_011520924.1  calpain-15 isoform X1

    See identical proteins and their annotated locations for XP_011520924.1

    Conserved Domains (4) summary
    smart00547
    Location:7397
    ZnF_RBZ; Zinc finger domain
    cd00044
    Location:544859
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
    sd00025
    Location:169191
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    sd00029
    Location:412431
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
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