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Sys1 SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae) [ Mus musculus (house mouse) ]

Gene ID: 66460, updated on 18-Sep-2024

Summary

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Official Symbol
Sys1provided by MGI
Official Full Name
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)provided by MGI
Primary source
MGI:MGI:1913710
See related
Ensembl:ENSMUSG00000045503 AllianceGenome:MGI:1913710
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2610042O14Rik
Summary
Predicted to be involved in Golgi to endosome transport; Golgi to plasma membrane protein transport; and protein localization to Golgi apparatus. Predicted to act upstream of or within protein transport. Predicted to be located in Golgi membrane. Predicted to be integral component of membrane. Predicted to be active in trans-Golgi network. Predicted to be integral component of Golgi membrane. Orthologous to human SYS1 (SYS1 golgi trafficking protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum adult (RPKM 87.4), ovary adult (RPKM 57.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Sys1 in Genome Data Viewer
Location:
2 H3; 2 85.16 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (164297736..164322141)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (164456930..164480221)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene matrilin 4 Neighboring gene STARR-positive B cell enhancer ABC_E6015 Neighboring gene recombination signal binding protein for immunoglobulin kappa J region-like Neighboring gene STARR-positive B cell enhancer ABC_E4517 Neighboring gene STARR-positive B cell enhancer ABC_E6016 Neighboring gene STARR-seq mESC enhancer starr_06326 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:164266728-164266915 Neighboring gene syndecan 4 Neighboring gene STARR-seq mESC enhancer starr_06330 Neighboring gene STARR-positive B cell enhancer ABC_E7884 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:164286295-164286478 Neighboring gene transformation related protein 53 target 5 Neighboring gene dysbindin domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E9539 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class T Neighboring gene STARR-seq mESC enhancer starr_06331 Neighboring gene predicted gene, 36090

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PRRT2 deficiency induces paroxysmal kinesigenic dyskinesia by regulating synaptic transmission in cerebellum. Tan GH, et al. Cell Res, 2018 Jan. PMID 29056747, Free PMC Article
  2. A novel mouse Chromosome 2 congenic strain with obesity phenotypes. Diament AL, et al. Mamm Genome, 2004 Jun. PMID 15181537
  3. Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. Liu X, et al. BMC Immunol, 2016 Aug 2. PMID 27480124, Free PMC Article
  4. Homologous Transcription Factors DUX4 and DUX4c Associate with Cytoplasmic Proteins during Muscle Differentiation. Ansseau E, et al. PLoS One, 2016. PMID 26816005, Free PMC Article
  5. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in Golgi to endosome transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Golgi to plasma membrane protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein SYS1 homolog
Names
Sys1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025575.4 → NP_079851.2  protein SYS1 homolog

    See identical proteins and their annotated locations for NP_079851.2

    Status: VALIDATED

    Source sequence(s)
    AL591478
    Consensus CDS
    CCDS50793.1
    UniProtKB/Swiss-Prot
    Q3UFU1, Q78S06, Q9DAU8
    Related
    ENSMUSP00000072275.5, ENSMUST00000072452.11
    Conserved Domains (1) summary
    pfam09801
    Location:5 → 148
    SYS1; Integral membrane protein S linking to the trans Golgi network

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    164297736..164322141
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162452.1 → XP_036018345.1  protein SYS1 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q3UFU1, Q78S06, Q9DAU8
    Conserved Domains (1) summary
    pfam09801
    Location:5 → 148
    SYS1; Integral membrane protein S linking to the trans Golgi network

  2. XM_011239733.3 → XP_011238035.1  protein SYS1 homolog isoform X1

    See identical proteins and their annotated locations for XP_011238035.1

    UniProtKB/Swiss-Prot
    Q3UFU1, Q78S06, Q9DAU8
    Related
    ENSMUSP00000104976.2, ENSMUST00000109352.8
    Conserved Domains (1) summary
    pfam09801
    Location:5 → 148
    SYS1; Integral membrane protein S linking to the trans Golgi network

  3. XM_036162454.1 → XP_036018347.1  protein SYS1 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q3UFU1, Q78S06, Q9DAU8
    Conserved Domains (1) summary
    pfam09801
    Location:5 → 148
    SYS1; Integral membrane protein S linking to the trans Golgi network

  4. XM_011239732.4 → XP_011238034.1  protein SYS1 homolog isoform X1

    See identical proteins and their annotated locations for XP_011238034.1

    UniProtKB/Swiss-Prot
    Q3UFU1, Q78S06, Q9DAU8
    Conserved Domains (1) summary
    pfam09801
    Location:5 → 148
    SYS1; Integral membrane protein S linking to the trans Golgi network

RNA

  1. XR_003953683.1 RNA Sequence

  2. XR_374503.3 RNA Sequence

  3. XR_374501.3 RNA Sequence

    Related
    ENSMUST00000138268.8

  4. XR_866332.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q78S06.1 GenPept UniProtKB/Swiss-Prot:Q78S06

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