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Mterf3 mitochondrial transcription termination factor 3 [ Mus musculus (house mouse) ]

Gene ID: 66410, updated on 8-Dec-2022

Summary

Official Symbol
Mterf3provided by MGI
Official Full Name
mitochondrial transcription termination factor 3provided by MGI
Primary source
MGI:MGI:1913660
See related
Ensembl:ENSMUSG00000021519 AllianceGenome:MGI:1913660
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mterfd1; 2410017I18Rik
Summary
Predicted to enable transcription cis-regulatory region binding activity. Involved in negative regulation of transcription, DNA-templated. Located in mitochondrion. Is expressed in several structures, including early conceptus and genitourinary system. Orthologous to human MTERF3 (mitochondrial transcription termination factor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 7.6), whole brain E14.5 (RPKM 7.6) and 28 other tissues See more
Orthologs
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Genomic context

See Mterf3 in Genome Data Viewer
Location:
13; 13 B3
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (67053520..67081148, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (66906577..66933083, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene high mobility group box 2 pseudogene Neighboring gene ubiquinol-cytochrome c reductase binding protein Neighboring gene predicted gene 10767 Neighboring gene phosphatidylserine synthase 1 Neighboring gene RIKEN cDNA 4933433G19 gene Neighboring gene zinc finger protein 712

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables double-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in mitochondrial ribosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitochondrial transcription IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
transcription termination factor 3, mitochondrial
Names
MTERF domain containing 1
mTERF domain-containing protein 1, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025547.4NP_079823.2  transcription termination factor 3, mitochondrial precursor

    See identical proteins and their annotated locations for NP_079823.2

    Status: VALIDATED

    Source sequence(s)
    AC124433
    Consensus CDS
    CCDS26611.1
    UniProtKB/Swiss-Prot
    Q8R3J4, Q9CWM7
    Related
    ENSMUSP00000021991.5, ENSMUST00000021991.11
    Conserved Domains (1) summary
    cl19765
    Location:148350
    mTERF

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    67053520..67081148 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517322.4XP_006517385.1  transcription termination factor 3, mitochondrial isoform X3

    Conserved Domains (1) summary
    cl19765
    Location:148348
    mTERF
  2. XM_036158110.1XP_036014003.1  transcription termination factor 3, mitochondrial isoform X1

    Conserved Domains (1) summary
    cl19765
    Location:148363
    mTERF
  3. XM_011244548.4XP_011242850.1  transcription termination factor 3, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_011242850.1

    UniProtKB/Swiss-Prot
    Q8R3J4, Q9CWM7
    Conserved Domains (1) summary
    cl19765
    Location:148350
    mTERF
  4. XM_017315563.3XP_017171052.1  transcription termination factor 3, mitochondrial isoform X2

    UniProtKB/Swiss-Prot
    Q8R3J4, Q9CWM7
    Conserved Domains (1) summary
    cl19765
    Location:148350
    mTERF
  5. XM_006517321.3XP_006517384.1  transcription termination factor 3, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_006517384.1

    UniProtKB/Swiss-Prot
    Q8R3J4, Q9CWM7
    Conserved Domains (1) summary
    cl19765
    Location:148350
    mTERF
  6. XM_036158114.1XP_036014007.1  transcription termination factor 3, mitochondrial isoform X1

    Conserved Domains (1) summary
    cl19765
    Location:148363
    mTERF
  7. XM_036158111.1XP_036014004.1  transcription termination factor 3, mitochondrial isoform X1

    Conserved Domains (1) summary
    cl19765
    Location:148363
    mTERF
  8. XM_030247357.2XP_030103217.1  transcription termination factor 3, mitochondrial isoform X2

    UniProtKB/Swiss-Prot
    Q9CWM7
    Conserved Domains (1) summary
    cl19765
    Location:148350
    mTERF
  9. XM_036158113.1XP_036014006.1  transcription termination factor 3, mitochondrial isoform X1

    Conserved Domains (1) summary
    cl19765
    Location:148363
    mTERF
  10. XM_036158112.1XP_036014005.1  transcription termination factor 3, mitochondrial isoform X1

    Conserved Domains (1) summary
    cl19765
    Location:148363
    mTERF

RNA

  1. XR_004938051.1 RNA Sequence