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Ndufc1 NADH:ubiquinone oxidoreductase subunit C1 [ Mus musculus (house mouse) ]

Gene ID: 66377, updated on 2-Nov-2024

Summary

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Official Symbol
Ndufc1provided by MGI
Official Full Name
NADH:ubiquinone oxidoreductase subunit C1provided by MGI
Primary source
MGI:MGI:1913627
See related
Ensembl:ENSMUSG00000037152 AllianceGenome:MGI:1913627
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KFYI; CI-KFYI; 2310016K22Rik
Summary
Predicted to be involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Orthologous to human NDUFC1 (NADH:ubiquinone oxidoreductase subunit C1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in heart adult (RPKM 91.1), testis adult (RPKM 62.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ndufc1 in Genome Data Viewer
Location:
3 C; 3 22.47 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (51312876..51323167, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (51405479..51408955, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene mitochondria localized glutamic acid rich protein Neighboring gene STARR-seq mESC enhancer starr_07614 Neighboring gene predicted gene 9442 Neighboring gene STARR-positive B cell enhancer ABC_E11182 Neighboring gene predicted gene, 50622 Neighboring gene N(alpha)-acetyltransferase 15, NatA auxiliary subunit Neighboring gene STARR-positive B cell enhancer ABC_E2664 Neighboring gene RAB33B, member RAS oncogene family

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Yin Yang 1 Orchestrates a Metabolic Program Required for Both Neural Crest Development and Melanoma Formation. Varum S, et al. Cell Stem Cell, 2019 Apr 4. PMID 30951662
  2. Hnrnpk maintains chondrocytes survival and function during growth plate development via regulating Hif1α-glycolysis axis. Chen Y, et al. Cell Death Dis, 2022 Sep 20. PMID 36127325, Free PMC Article
  3. Region-specific expression of mitochondrial complex I genes during murine brain development. Wirtz S, et al. PLoS One, 2011 Apr 27. PMID 21556144, Free PMC Article
  4. Yin Yang 1 sustains biosynthetic demands during brain development in a stage-specific manner. Zurkirchen L, et al. Nat Commun, 2019 May 16. PMID 31097699, Free PMC Article
  5. The effects of aging on gene expression in the hypothalamus and cortex of mice. Jiang CH, et al. Proc Natl Acad Sci U S A, 2001 Feb 13. PMID 11172053, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC106656

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in aerobic respiration NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mitochondrial respiratory chain complex I assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial respiratory chain complex I assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proton motive force-driven mitochondrial ATP synthesis NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
part_of respiratory chain complex I IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of respiratory chain complex I ISO
Inferred from Sequence Orthology
more info
  
part_of respiratory chain complex I ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial
Names
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1
NADH-ubiquinone oxidoreductase KFYI subunit
complex I-KFYI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025523.2 → NP_079799.1  NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial precursor

    See identical proteins and their annotated locations for NP_079799.1

    Status: VALIDATED

    Source sequence(s)
    AC105966
    Consensus CDS
    CCDS38426.1
    UniProtKB/Swiss-Prot
    Q58DY9, Q9CQY9
    Related
    ENSMUSP00000038463.7, ENSMUST00000038108.12
    Conserved Domains (1) summary
    pfam15088
    Location:28 → 76
    NADH_dh_m_C1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    51312876..51323167 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163226.1 → XP_036019119.1  NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q58DY9, Q9CQY9
    Conserved Domains (1) summary
    pfam15088
    Location:28 → 76
    NADH_dh_m_C1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQY9.1 GenPept UniProtKB/Swiss-Prot:Q9CQY9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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