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Dhrs7 dehydrogenase/reductase 7 [ Mus musculus (house mouse) ]

Gene ID: 66375, updated on 1-Mar-2024

Summary

Official Symbol
Dhrs7provided by MGI
Official Full Name
dehydrogenase/reductase 7provided by MGI
Primary source
MGI:MGI:1913625
See related
Ensembl:ENSMUSG00000021094 AllianceGenome:MGI:1913625
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Retdsr4; Retsdr4; 2310016E22Rik; 5730564L20Rik
Summary
Predicted to enable oxidoreductase activity. Is expressed in diencephalon; heart and pericardium; and lower jaw alveolar sulcus. Orthologous to human DHRS7 (dehydrogenase/reductase 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in subcutaneous fat pad adult (RPKM 43.7), mammary gland adult (RPKM 34.0) and 25 other tissues See more
Orthologs
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Genomic context

See Dhrs7 in Genome Data Viewer
Location:
12 C3; 12 30.23 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (72697127..72711678, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (72650353..72664828, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene pecanex homolog 4 Neighboring gene STARR-seq mESC enhancer starr_32441 Neighboring gene lymphocyte antigen 6 family member E, pseudogene 1 Neighboring gene dehydrogenase/reductase 7 like 1 Neighboring gene STARR-seq mESC enhancer starr_32442 Neighboring gene STARR-seq mESC enhancer starr_32443 Neighboring gene STARR-seq mESC enhancer starr_32444 Neighboring gene STARR-seq mESC enhancer starr_32445 Neighboring gene STARR-seq mESC enhancer starr_32447 Neighboring gene STARR-seq mESC enhancer starr_32449 Neighboring gene STARR-seq mESC enhancer starr_32450 Neighboring gene protein phosphatase 1A, magnesium dependent, alpha isoform Neighboring gene predicted gene, 33785

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NADP-retinol dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
enables carbonyl reductase (NADPH) activity ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within retinol metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dehydrogenase/reductase SDR family member 7
Names
dehydrogenase/reductase (SDR family) member 7
retinal short-chain dehydrogenase/reductase 4
short chain dehydrogenase/reductase family 34C member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025522.5NP_079798.2  dehydrogenase/reductase SDR family member 7 precursor

    See identical proteins and their annotated locations for NP_079798.2

    Status: VALIDATED

    Source sequence(s)
    AK014100, CF586466, CX223953
    Consensus CDS
    CCDS49086.1
    UniProtKB/Swiss-Prot
    Q9CXR1
    UniProtKB/TrEMBL
    A0A1Y7VN19
    Related
    ENSMUSP00000021512.10, ENSMUST00000021512.11
    Conserved Domains (1) summary
    cd05332
    Location:48308
    11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    72697127..72711678 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157560.1XP_036013453.1  dehydrogenase/reductase SDR family member 7 isoform X1

    UniProtKB/TrEMBL
    A0A1Y7VN19
    Conserved Domains (1) summary
    cd05332
    Location:29289
    11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs