U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Smurf2 SMAD specific E3 ubiquitin protein ligase 2 [ Mus musculus (house mouse) ]

Gene ID: 66313, updated on 8-Feb-2024

Summary

Official Symbol
Smurf2provided by MGI
Official Full Name
SMAD specific E3 ubiquitin protein ligase 2provided by MGI
Primary source
MGI:MGI:1913563
See related
Ensembl:ENSMUSG00000018363 AllianceGenome:MGI:1913563
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2810411E22Rik
Summary
Predicted to enable SMAD binding activity; identical protein binding activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; positive regulation of trophoblast cell migration; and ubiquitin-dependent protein catabolic process. Predicted to be located in nuclear speck. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in cardiovascular system; eye; genitourinary system; gut; and lung. Used to study diffuse large B-cell lymphoma. Orthologous to human SMURF2 (SMAD specific E3 ubiquitin protein ligase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 9.2), limb E14.5 (RPKM 7.2) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Smurf2 in Genome Data Viewer
Location:
11 E1; 11 70.03 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (106710887..106811544, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (106820061..106920747, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_30948 Neighboring gene microRNA 3064 Neighboring gene DEAD box helicase 5 Neighboring gene centrosomal protein 95 Neighboring gene STARR-positive B cell enhancer ABC_E11496 Neighboring gene STARR-positive B cell enhancer ABC_E8465 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:106822918-106823220 Neighboring gene Smad nuclear interacting protein 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E3031 Neighboring gene karyopherin subunit alpha 2 Neighboring gene predicted gene, 39424

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SMAD binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables SMAD binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transforming growth factor beta receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase activity TAS
Traceable Author Statement
more info
 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase SMURF2
Names
HECT-type E3 ubiquitin transferase SMURF2
SMAD ubiquitination regulatory factor 2
NP_001349823.1
NP_079757.2
XP_006533999.1
XP_036012789.1
XP_036012790.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362894.1NP_001349823.1  E3 ubiquitin-protein ligase SMURF2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL593847
    Conserved Domains (2) summary
    smart00456
    Location:5789
    WW; Domain with 2 conserved Trp (W) residues
    cd00078
    Location:152504
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
  2. NM_025481.3NP_079757.2  E3 ubiquitin-protein ligase SMURF2 isoform 1

    See identical proteins and their annotated locations for NP_079757.2

    Status: VALIDATED

    Source sequence(s)
    AK012060, AK013082, AK036718, AL593847, BE986450, BU058366, BU614468
    Consensus CDS
    CCDS25564.1
    UniProtKB/Swiss-Prot
    A2A5Z6, A2A5Z7, Q5IRE6
    Related
    ENSMUSP00000090177.3, ENSMUST00000092517.9
    Conserved Domains (5) summary
    cd08382
    Location:13137
    C2_Smurf-like; C2 domain present in Smad ubiquitination-related factor (Smurf)-like proteins
    smart00456
    Location:298330
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:420745
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:393745
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00397
    Location:159188
    WW; WW domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    106710887..106811544 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156896.1XP_036012789.1  E3 ubiquitin-protein ligase SMURF2 isoform X2

    Conserved Domains (2) summary
    cd08382
    Location:13137
    C2_Smurf-like; C2 domain present in Smad ubiquitination-related factor (Smurf)-like proteins
    COG5021
    Location:159625
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
  2. XM_006533936.4XP_006533999.1  E3 ubiquitin-protein ligase SMURF2 isoform X1

    UniProtKB/Swiss-Prot
    A2A5Z6
    Related
    ENSMUSP00000099356.4, ENSMUST00000103067.10
    Conserved Domains (2) summary
    cd08382
    Location:19124
    C2_Smurf-like; C2 domain present in Smad ubiquitination-related factor (Smurf)-like proteins
    COG5021
    Location:146732
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
  3. XM_036156897.1XP_036012790.1  E3 ubiquitin-protein ligase SMURF2 isoform X3

    Conserved Domains (2) summary
    smart00456
    Location:5789
    WW; Domain with 2 conserved Trp (W) residues
    cd00078
    Location:152504
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

RNA

  1. XR_001780039.3 RNA Sequence