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Fam53c family with sequence similarity 53, member C [ Mus musculus (house mouse) ]

Gene ID: 66306, updated on 2-Nov-2024

Summary

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Official Symbol
Fam53cprovided by MGI
Official Full Name
family with sequence similarity 53, member Cprovided by MGI
Primary source
MGI:MGI:1913556
See related
Ensembl:ENSMUSG00000034300 AllianceGenome:MGI:1913556
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm21179; 2810012G03Rik
Summary
Predicted to be involved in protein import into nucleus. Predicted to be active in nucleus. Orthologous to human FAM53C (family with sequence similarity 53 member C). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 33.9), ovary adult (RPKM 15.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Fam53c in Genome Data Viewer
Location:
18; 18 B1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (34891885..34906813)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (34758831..34773760)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene cell division cycle 25C Neighboring gene ribosomal protein L29, retrotransposed Neighboring gene STARR-positive B cell enhancer ABC_E1205 Neighboring gene RIKEN cDNA 2010110K18 gene Neighboring gene STARR-positive B cell enhancer ABC_E7575 Neighboring gene microRNA 12191 Neighboring gene predicted gene 3561 Neighboring gene STARR-positive B cell enhancer ABC_E7576 Neighboring gene STARR-seq mESC enhancer starr_44212 Neighboring gene KDM3B lysine (K)-specific demethylase 3B Neighboring gene STARR-seq mESC enhancer starr_44215 Neighboring gene receptor accessory protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease. Viard J, et al. Life Sci Alliance, 2022 Aug 1. PMID 35914814, Free PMC Article
  2. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein FAM53C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357456.1 → NP_001344385.1  protein FAM53C isoform 1

    Status: VALIDATED

    Source sequence(s)
    AK044469, BC057111, CJ153142
    Consensus CDS
    CCDS29134.1
    UniProtKB/Swiss-Prot
    Q3U4J2, Q8BXQ8
    Related
    ENSMUSP00000095226.4, ENSMUST00000097622.4
    Conserved Domains (1) summary
    pfam15242
    Location:1 → 307
    FAM53; Family of FAM53

  2. NM_001357457.1 → NP_001344386.1  protein FAM53C isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK044469, AK135712, BC057111, CJ153142
    UniProtKB/TrEMBL
    Q3UXE1
    Conserved Domains (1) summary
    pfam15242
    Location:8 → 270
    FAM53; Family of FAM53

  3. NM_175104.5 → NP_780313.1  protein FAM53C isoform 1

    See identical proteins and their annotated locations for NP_780313.1

    Status: VALIDATED

    Source sequence(s)
    AC145591, AK044469, BC057111, CB244539
    Consensus CDS
    CCDS29134.1
    UniProtKB/Swiss-Prot
    Q3U4J2, Q8BXQ8
    Related
    ENSMUSP00000037034.6, ENSMUST00000049281.12
    Conserved Domains (1) summary
    pfam15242
    Location:1 → 307
    FAM53; Family of FAM53

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    34891885..34906813
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526152.4 → XP_006526215.1  protein FAM53C isoform X1

    See identical proteins and their annotated locations for XP_006526215.1

    UniProtKB/Swiss-Prot
    Q3U4J2, Q8BXQ8
    Conserved Domains (1) summary
    pfam15242
    Location:1 → 307
    FAM53; Family of FAM53

  2. XM_006526154.5 → XP_006526217.1  protein FAM53C isoform X2

    See identical proteins and their annotated locations for XP_006526217.1

    UniProtKB/TrEMBL
    Q3UXE1
    Conserved Domains (1) summary
    pfam15242
    Location:8 → 270
    FAM53; Family of FAM53
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BXQ8.1 GenPept UniProtKB/Swiss-Prot:Q8BXQ8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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