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Sec11c SEC11 homolog C, signal peptidase complex subunit [ Mus musculus (house mouse) ]

Gene ID: 66286, updated on 11-Apr-2024

Summary

Official Symbol
Sec11cprovided by MGI
Official Full Name
SEC11 homolog C, signal peptidase complex subunitprovided by MGI
Primary source
MGI:MGI:1913536
See related
Ensembl:ENSMUSG00000024516 AllianceGenome:MGI:1913536
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sec11l3; 1810029G24Rik
Summary
Predicted to enable peptidase activity. Predicted to be involved in signal peptide processing. Predicted to act upstream of or within proteolysis. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Predicted to be part of signal peptidase complex. Is expressed in several structures, including alimentary system; cranium; respiratory system; sensory organ; and telencephalon. Orthologous to human SEC11C (SEC11 homolog C, signal peptidase complex subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in genital fat pad adult (RPKM 32.7), cerebellum adult (RPKM 26.8) and 28 other tissues See more
Orthologs
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Genomic context

Location:
18 E1; 18 38.98 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (65933649..65950731)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (65800578..65817660)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene O-acyltransferase like Neighboring gene predicted gene, 54022 Neighboring gene STARR-positive B cell enhancer ABC_E4252 Neighboring gene STARR-positive B cell enhancer ABC_E618 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:65960619-65960728 Neighboring gene STARR-positive B cell enhancer ABC_E1517 Neighboring gene STARR-positive B cell enhancer ABC_E9984 Neighboring gene STARR-positive B cell enhancer ABC_E1961 Neighboring gene STARR-seq mESC enhancer starr_44853 Neighboring gene predicted gene, 52375 Neighboring gene predicted gene, 30094 Neighboring gene gastrin releasing peptide

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in signal peptide processing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in signal peptide processing ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
part_of signal peptidase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of signal peptidase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
signal peptidase complex catalytic subunit SEC11C
Names
SEC11-like protein 3
SPC21
SPase 21 kDa subunit
Sec11-like 3
microsomal signal peptidase 21 kDa subunit
NP_079744.1
XP_006526213.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025468.2NP_079744.1  signal peptidase complex catalytic subunit SEC11C

    See identical proteins and their annotated locations for NP_079744.1

    Status: PROVISIONAL

    Source sequence(s)
    AK007641
    Consensus CDS
    CCDS29309.1
    UniProtKB/Swiss-Prot
    Q9D8V7
    UniProtKB/TrEMBL
    D3Z5H3
    Related
    ENSMUSP00000025394.7, ENSMUST00000025394.14
    Conserved Domains (1) summary
    cl10465
    Location:34167
    Peptidase_S24_S26; The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    65933649..65950731
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526150.3XP_006526213.1  signal peptidase complex catalytic subunit SEC11C isoform X1

    See identical proteins and their annotated locations for XP_006526213.1

    Conserved Domains (1) summary
    cl10465
    Location:12129
    Peptidase_S24_S26; The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the ...