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Sec11c SEC11 homolog C, signal peptidase complex subunit [ Mus musculus (house mouse) ]

Gene ID: 66286, updated on 2-Nov-2024

Summary

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Official Symbol
Sec11cprovided by MGI
Official Full Name
SEC11 homolog C, signal peptidase complex subunitprovided by MGI
Primary source
MGI:MGI:1913536
See related
Ensembl:ENSMUSG00000024516 AllianceGenome:MGI:1913536
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sec11l3; 1810029G24Rik
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in signal peptide processing. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of signal peptidase complex. Is expressed in several structures, including alimentary system; cranium; respiratory system; sensory organ; and telencephalon. Orthologous to human SEC11C (SEC11 homolog C, signal peptidase complex subunit). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in genital fat pad adult (RPKM 32.7), cerebellum adult (RPKM 26.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Sec11c in Genome Data Viewer
Location:
18 E1; 18 38.98 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (65933649..65950731)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (65800578..65817660)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene O-acyltransferase like Neighboring gene predicted gene, 54022 Neighboring gene STARR-positive B cell enhancer ABC_E4252 Neighboring gene STARR-positive B cell enhancer ABC_E618 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:65960619-65960728 Neighboring gene STARR-positive B cell enhancer ABC_E1517 Neighboring gene STARR-positive B cell enhancer ABC_E9984 Neighboring gene STARR-positive B cell enhancer ABC_E1961 Neighboring gene STARR-seq mESC enhancer starr_44853 Neighboring gene predicted gene, 52375 Neighboring gene predicted gene, 30094 Neighboring gene gastrin releasing peptide

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  2. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables serine-type endopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in signal peptide processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal peptide processing ISO
Inferred from Sequence Orthology
more info
  
involved_in signal peptide processing ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
part_of signal peptidase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of signal peptidase complex ISO
Inferred from Sequence Orthology
more info
  
part_of signal peptidase complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
signal peptidase complex catalytic subunit SEC11C
Names
SEC11-like protein 3
SPC21
SPase 21 kDa subunit
Sec11-like 3
microsomal signal peptidase 21 kDa subunit
NP_079744.1
XP_006526213.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025468.2 → NP_079744.1  signal peptidase complex catalytic subunit SEC11C

    Status: PROVISIONAL

    Source sequence(s)
    AK007641
    Consensus CDS
    CCDS29309.1
    UniProtKB/Swiss-Prot
    Q9D8V7
    UniProtKB/TrEMBL
    D3Z5H3
    Related
    ENSMUSP00000025394.7, ENSMUST00000025394.14
    Conserved Domains (1) summary
    cl10465
    Location:34 → 167
    Peptidase_S24_S26; The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    65933649..65950731
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526150.3 → XP_006526213.1  signal peptidase complex catalytic subunit SEC11C isoform X1

    Conserved Domains (1) summary
    cl10465
    Location:12 → 129
    Peptidase_S24_S26; The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D8V7.3 GenPept UniProtKB/Swiss-Prot:Q9D8V7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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