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SNCA synuclein alpha [ Homo sapiens (human) ]

Gene ID: 6622, updated on 20-Jun-2021

Summary

Official Symbol
SNCAprovided by HGNC
Official Full Name
synuclein alphaprovided by HGNC
Primary source
HGNC:HGNC:11138
See related
Ensembl:ENSG00000145335 MIM:163890
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PD1; NACP; PARK1; PARK4
Summary
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]
Expression
Biased expression in brain (RPKM 59.2), bone marrow (RPKM 24.6) and 2 other tissues See more
Orthologs
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Genomic context

See SNCA in Genome Data Viewer
Location:
4q22.1
Exon count:
13
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (89724099..89838324, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (90645250..90759455, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377328 Neighboring gene uncharacterized LOC105377329 Neighboring gene SNCA antisense RNA 1 Neighboring gene multimerin 1 Neighboring gene VISTA enhancer hs1374

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease.
GeneReviews: Not available
Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database.
GeneReviews: Not available
Dissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple associated haplotypes at 17q21.
GeneReviews: Not available
Genome-wide association study confirms BST1 and suggests a locus on 12q24 as the risk loci for Parkinson's disease in the European population.
GeneReviews: Not available
Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease.
GeneReviews: Not available
Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease.
GeneReviews: Not available
Genome-wide association study reveals genetic risk underlying Parkinson's disease.
GeneReviews: Not available
Identification of a novel Parkinson's disease locus via stratified genome-wide association study.
GeneReviews: Not available
Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies.
GeneReviews: Not available
Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease.
GeneReviews: Not available
Lewy body dementia
MedGen: C0752347 OMIM: 127750 GeneReviews: Not available
Compare labs
Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2.
GeneReviews: Not available
Parkinson disease 1
MedGen: C1868595 OMIM: 168601 GeneReviews: Parkinson Disease Overview
Compare labs
Parkinson disease 4
MedGen: C1854182 OMIM: 605543 GeneReviews: Parkinson Disease Overview
Compare labs
Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC110988

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables Hsp70 protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables SNARE binding IDA
Inferred from Direct Assay
more info
PubMed 
enables actin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables alpha-tubulin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables beta-tubulin binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables copper ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables cuprous ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cuprous ion binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
enables dynein complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
NOT enables fatty acid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ferrous iron binding IDA
Inferred from Direct Assay
more info
PubMed 
enables histone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables kinesin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IDA
Inferred from Direct Assay
more info
PubMed 
NOT enables phospholipase D inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phospholipase binding IEA
Inferred from Electronic Annotation
more info
 
enables phospholipid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphoprotein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein N-terminus binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase inhibitor activity TAS
Traceable Author Statement
more info
PubMed 
enables tau protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription cis-regulatory region binding TAS
Traceable Author Statement
more info
PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in SNARE complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in adult locomotory behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in aging IEA
Inferred from Electronic Annotation
more info
 
involved_in amyloid fibril formation TAS
Traceable Author Statement
more info
 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in behavioral response to cocaine IEA
Inferred from Electronic Annotation
more info
 
NOT involved_in calcium ion homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to copper ion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to epinephrine stimulus TAS
Traceable Author Statement
more info
PubMed 
involved_in cellular response to fibroblast growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to oxidative stress IC
Inferred by Curator
more info
PubMed 
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in dopamine biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
involved_in dopamine uptake involved in synaptic transmission TAS
Traceable Author Statement
more info
PubMed 
involved_in excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
 
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in long-term synaptic potentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in microglial cell activation TAS
Traceable Author Statement
more info
PubMed 
involved_in mitochondrial ATP synthesis coupled electron transport IEA
Inferred from Electronic Annotation
more info
 
involved_in mitochondrial membrane organization IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of chaperone-mediated autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of dopamine metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of dopamine uptake involved in synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of histone acetylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of microtubule polymerization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of mitochondrial electron transport, NADH to ubiquinone TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of monooxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of neuron death IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of norepinephrine uptake IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of platelet-derived growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of serotonin uptake IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of thrombin-activated receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neutral lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in phospholipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of SNARE complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of glutathione peroxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of hydrogen peroxide catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of inositol phosphate biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of neuron death IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of neurotransmitter secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of peptidyl-serine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of receptor recycling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of release of sequestered calcium ion into cytosol IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein destabilization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein tetramerization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of acyl-CoA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of dopamine secretion TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of glutamate secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of locomotion IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of long-term neuronal synaptic plasticity IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of macrophage activation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of neuron death IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of norepinephrine uptake IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of phospholipase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of presynapse assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of reactive oxygen species biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of synaptic vesicle recycling TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of transmembrane transporter activity IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in response to desipramine IEA
Inferred from Electronic Annotation
more info
 
involved_in response to drug IEA
Inferred from Electronic Annotation
more info
 
involved_in response to interferon-gamma IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to interleukin-1 IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to iron(II) ion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to magnesium ion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in supramolecular fiber organization TAS
Traceable Author Statement
more info
PubMed 
involved_in synapse organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in synaptic vesicle endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in synaptic vesicle endocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in synaptic vesicle exocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in synaptic vesicle priming IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synaptic vesicle transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in axon terminus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in growth cone IDA
Inferred from Direct Assay
more info
PubMed 
located_in inclusion body IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosome TAS
Traceable Author Statement
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial intermembrane space IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion TAS
Traceable Author Statement
more info
PubMed 
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nuclear outer membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with platelet alpha granule membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in ribosome IEA
Inferred from Electronic Annotation
more info
 
located_in rough endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in supramolecular fiber IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
located_in terminal bouton IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
alpha-synuclein
Names
I+/--synuclein
non A-beta component of AD amyloid
synuclein alpha-140
synuclein, alpha (non A4 component of amyloid precursor)
truncated alpha synuclein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011851.1 RefSeqGene

    Range
    6136..119198
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000345.4NP_000336.1  alpha-synuclein isoform NACP140

    See identical proteins and their annotated locations for NP_000336.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as NACP140) is the longest transcript and encodes the longer isoform (NACP140). Variants 1, 2, and 3 all encode the same isoform.
    Source sequence(s)
    AC097478, AI815523, BC108275
    Consensus CDS
    CCDS3634.1
    UniProtKB/Swiss-Prot
    P37840
    Related
    ENSP00000378442.4, ENST00000394991.8
    Conserved Domains (1) summary
    pfam01387
    Location:1131
    Synuclein
  2. NM_001146054.2NP_001139526.1  alpha-synuclein isoform NACP140

    See identical proteins and their annotated locations for NP_001139526.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (NACP140).
    Source sequence(s)
    AC093759, AC097478, BC013293
    Consensus CDS
    CCDS3634.1
    UniProtKB/Swiss-Prot
    P37840
    Related
    ENSP00000378437.1, ENST00000394986.5
    Conserved Domains (1) summary
    pfam01387
    Location:1131
    Synuclein
  3. NM_001146055.2NP_001139527.1  alpha-synuclein isoform NACP140

    See identical proteins and their annotated locations for NP_001139527.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (NACP140).
    Source sequence(s)
    AC093759, AC097478, DA391115
    Consensus CDS
    CCDS3634.1
    UniProtKB/Swiss-Prot
    P37840
    Related
    ENSP00000338345.3, ENST00000336904.7
    Conserved Domains (1) summary
    pfam01387
    Location:1131
    Synuclein
  4. NM_001375285.1NP_001362214.1  alpha-synuclein isoform NACP140

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variants 1-3 and 6-8, encodes isoform NACP140.
    Source sequence(s)
    AC093759, AC097478
    Conserved Domains (1) summary
    pfam01387
    Location:1131
    Synuclein
  5. NM_001375286.1NP_001362215.1  alpha-synuclein isoform NACP140

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variants 1-3, 5, 7, and 8, encodes isoform NACP140.
    Source sequence(s)
    AC093759, AC097478
    Related
    ENSP00000422238.1, ENST00000506244.5
    Conserved Domains (1) summary
    pfam01387
    Location:1131
    Synuclein
  6. NM_001375287.1NP_001362216.1  alpha-synuclein isoform NACP140

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variants 1-3, 5, 6, and 8, encodes isoform NACP140.
    Source sequence(s)
    AC093759, AC097478
    Related
    ENSP00000500990.1, ENST00000673718.1
    Conserved Domains (1) summary
    pfam01387
    Location:1131
    Synuclein
  7. NM_001375288.1NP_001362217.1  alpha-synuclein isoform NACP140

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), as well as variants 1-3 and 5-7, encodes isoform NACP140.
    Source sequence(s)
    AC093759, AC097478
    Related
    ENSP00000426955.1, ENST00000508895.5
    Conserved Domains (1) summary
    pfam01387
    Location:1131
    Synuclein
  8. NM_001375290.1NP_001362219.1  alpha-synuclein isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC097478
    Related
    ENST00000673766.1
    Conserved Domains (1) summary
    pfam01387
    Location:5483
    Synuclein
  9. NM_007308.3NP_009292.1  alpha-synuclein isoform NACP112

    See identical proteins and their annotated locations for NP_009292.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4, also known as NACP112) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (NACP112) has the same N- and C-termini but is shorter compared to isoform NACP140.
    Source sequence(s)
    AC093759, AC097478, D31839
    Consensus CDS
    CCDS43252.1
    UniProtKB/Swiss-Prot
    P37840
    UniProtKB/TrEMBL
    H6UYS5
    Related
    ENSP00000396241.2, ENST00000420646.6
    Conserved Domains (1) summary
    pfam01387
    Location:1112
    Synuclein

RNA

  1. NR_164674.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC093759, AC097478
  2. NR_164675.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC093759, AC097478
  3. NR_164676.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC093759, AC097478

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    89724099..89838324 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008563.1XP_016864052.1  alpha-synuclein isoform X2

    UniProtKB/Swiss-Prot
    P37840
    Related
    ENSP00000421485.1, ENST00000505199.5
    Conserved Domains (1) summary
    pfam01387
    Location:1131
    Synuclein
  2. XM_011532205.2XP_011530507.1  alpha-synuclein isoform X1

    See identical proteins and their annotated locations for XP_011530507.1

    Conserved Domains (1) summary
    pfam01387
    Location:1118
    Synuclein; Synuclein
  3. XM_011532203.1XP_011530505.1  alpha-synuclein isoform X1

    See identical proteins and their annotated locations for XP_011530505.1

    Conserved Domains (1) summary
    pfam01387
    Location:1118
    Synuclein; Synuclein
  4. XM_011532206.1XP_011530508.1  alpha-synuclein isoform X1

    See identical proteins and their annotated locations for XP_011530508.1

    Conserved Domains (1) summary
    pfam01387
    Location:1118
    Synuclein; Synuclein
  5. XM_011532204.3XP_011530506.1  alpha-synuclein isoform X1

    See identical proteins and their annotated locations for XP_011530506.1

    Conserved Domains (1) summary
    pfam01387
    Location:1118
    Synuclein; Synuclein
  6. XM_011532207.1XP_011530509.1  alpha-synuclein isoform X1

    See identical proteins and their annotated locations for XP_011530509.1

    Conserved Domains (1) summary
    pfam01387
    Location:1118
    Synuclein; Synuclein
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