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Commd6 COMM domain containing 6 [ Mus musculus (house mouse) ]

Gene ID: 66200, updated on 8-May-2024

Summary

Official Symbol
Commd6provided by MGI
Official Full Name
COMM domain containing 6provided by MGI
Primary source
MGI:MGI:1913450
See related
Ensembl:ENSMUSG00000075486 AllianceGenome:MGI:1913450
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110059J08Rik; 1700063H17Rik
Summary
Predicted to enable NF-kappaB binding activity. Predicted to be involved in negative regulation of NF-kappaB transcription factor activity. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to human COMMD6 (COMM domain containing 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 15.4), placenta adult (RPKM 14.0) and 28 other tissues See more
Orthologs
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Genomic context

See Commd6 in Genome Data Viewer
Location:
14 E2.3; 14 50.9 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (101871202..101877907, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (101633766..101640471, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene heat shock protein 1 (chaperonin), pseudogene 5 Neighboring gene TBC1 domain family, member 4 Neighboring gene predicted gene, 34417 Neighboring gene STARR-seq mESC enhancer starr_37476 Neighboring gene STARR-positive B cell enhancer ABC_E7344 Neighboring gene STARR-positive B cell enhancer ABC_E8574 Neighboring gene STARR-seq mESC enhancer starr_37480 Neighboring gene STARR-positive B cell enhancer ABC_E2432 Neighboring gene STARR-seq mESC enhancer starr_37481 Neighboring gene ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) Neighboring gene HCLS1 associated X-1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NF-kappaB binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables NF-kappaB binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
COMM domain-containing protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033132.3NP_001028304.1  COMM domain-containing protein 6 isoform 1

    See identical proteins and their annotated locations for NP_001028304.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    BB577089, BC132261, CK128085
    Consensus CDS
    CCDS37000.1
    UniProtKB/Swiss-Prot
    Q3V4B5
    UniProtKB/TrEMBL
    B7ZNP2
    Related
    ENSMUSP00000097912.3, ENSMUST00000100339.9
    Conserved Domains (1) summary
    cl06336
    Location:885
    Commd; COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in ...
  2. NM_001168592.1NP_001162064.1  COMM domain-containing protein 6 isoform 2

    See identical proteins and their annotated locations for NP_001162064.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    BB577089, CK128085, CK621880
    Consensus CDS
    CCDS49557.1
    UniProtKB/TrEMBL
    B7ZNP3
    Related
    ENSMUSP00000131634.2, ENSMUST00000168587.3
    Conserved Domains (1) summary
    cl06336
    Location:881
    Commd; COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    101871202..101877907 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)