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Ube2d3 ubiquitin-conjugating enzyme E2D 3 [ Mus musculus (house mouse) ]

Gene ID: 66105, updated on 8-Feb-2024

Summary

Official Symbol
Ube2d3provided by MGI
Official Full Name
ubiquitin-conjugating enzyme E2D 3provided by MGI
Primary source
MGI:MGI:1913355
See related
Ensembl:ENSMUSG00000078578 AllianceGenome:MGI:1913355
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1100001F19Rik; 9430029A22Rik
Summary
Predicted to enable ubiquitin conjugating enzyme activity and ubiquitin protein ligase activity. Acts upstream of or within proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in endosome and plasma membrane. Predicted to be active in nucleus. Is expressed in inner cell mass and trophectoderm. Orthologous to human UBE2D3 (ubiquitin conjugating enzyme E2 D3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 51.8), placenta adult (RPKM 51.5) and 28 other tissues See more
Orthologs
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Genomic context

See Ube2d3 in Genome Data Viewer
Location:
3 G3; 3 62.56 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (135143993..135173975)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (135438232..135468214)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:135065430-135065659 Neighboring gene CDGSH iron sulfur domain 2 Neighboring gene RIKEN cDNA 4930539J05 gene Neighboring gene STARR-positive B cell enhancer ABC_E1026 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:135101299-135101408 Neighboring gene STARR-positive B cell enhancer ABC_E6132 Neighboring gene predicted gene, 30992 Neighboring gene mannosidase, beta A, lysosomal Neighboring gene ornithine decarboxylase antizyme 2, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin conjugating enzyme activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K11-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein K11-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K48-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K6-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein monoubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
ubiquitin-conjugating enzyme E2 D3
Names
(E3-independent) E2 ubiquitin-conjugating enzyme D3
E2 ubiquitin-conjugating enzyme D3
ubiquitin carrier protein D3
ubiquitin-conjugating enzyme E2(17)KB 3
ubiquitin-conjugating enzyme E2-17 kDa 3
ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)
ubiquitin-protein ligase D3
NP_001343523.1
NP_001343524.1
NP_001343525.1
NP_001343526.1
NP_001343527.1
NP_079632.1
XP_036019109.1
XP_036019110.1
XP_036019111.1
XP_036019112.1
XP_036019113.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356594.1NP_001343523.1  ubiquitin-conjugating enzyme E2 D3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC156618, AK167138
    Consensus CDS
    CCDS38644.1
    UniProtKB/Swiss-Prot
    P61079
    UniProtKB/TrEMBL
    Q3U5V6, Q4QQL2, Q9D1S1
    Related
    ENSMUSP00000101898.4, ENSMUST00000106291.10
    Conserved Domains (1) summary
    cl00154
    Location:1146
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  2. NM_001356595.1NP_001343524.1  ubiquitin-conjugating enzyme E2 D3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC156618, DV648741
    Consensus CDS
    CCDS38644.1
    UniProtKB/Swiss-Prot
    P61079
    UniProtKB/TrEMBL
    Q3U5V6, Q4QQL2, Q9D1S1
    Related
    ENSMUSP00000143301.2, ENSMUST00000199613.5
    Conserved Domains (1) summary
    cl00154
    Location:1146
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  3. NM_001356596.1NP_001343525.1  ubiquitin-conjugating enzyme E2 D3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC156618, AK153100
    Consensus CDS
    CCDS38644.1
    UniProtKB/Swiss-Prot
    P61079
    UniProtKB/TrEMBL
    Q3U5V6, Q4QQL2, Q9D1S1
    Related
    ENSMUSP00000130096.2, ENSMUST00000166033.6
    Conserved Domains (1) summary
    cl00154
    Location:1146
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  4. NM_001356597.1NP_001343526.1  ubiquitin-conjugating enzyme E2 D3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC156618, AK165235
    Consensus CDS
    CCDS38644.1
    UniProtKB/Swiss-Prot
    P61079
    UniProtKB/TrEMBL
    Q3U5V6, Q4QQL2, Q9D1S1
    Related
    ENSMUSP00000143065.2, ENSMUST00000197539.5
    Conserved Domains (1) summary
    cl00154
    Location:1146
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  5. NM_001356598.1NP_001343527.1  ubiquitin-conjugating enzyme E2 D3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC156618
    UniProtKB/TrEMBL
    A0A494BA56
    Conserved Domains (1) summary
    cl00154
    Location:6110
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  6. NM_025356.5NP_079632.1  ubiquitin-conjugating enzyme E2 D3 isoform 1

    See identical proteins and their annotated locations for NP_079632.1

    Status: VALIDATED

    Source sequence(s)
    AC156618, AK153111
    Consensus CDS
    CCDS38644.1
    UniProtKB/Swiss-Prot
    P61079
    UniProtKB/TrEMBL
    Q3U5V6, Q4QQL2, Q9D1S1
    Related
    ENSMUSP00000143608.2, ENSMUST00000197859.5
    Conserved Domains (1) summary
    cl00154
    Location:1146
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    135143993..135173975
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163218.1XP_036019111.1  ubiquitin-conjugating enzyme E2 D3 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JGL0, Q3U5V6, Q9D1S1
    Related
    ENSMUSP00000143606.2, ENSMUST00000197134.3
    Conserved Domains (1) summary
    cl00154
    Location:1146
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  2. XM_036163219.1XP_036019112.1  ubiquitin-conjugating enzyme E2 D3 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JGL0, Q3U5V6, Q9D1S1
    Related
    ENSMUSP00000142612.2, ENSMUST00000198685.5
    Conserved Domains (1) summary
    cl00154
    Location:1146
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  3. XM_036163216.1XP_036019109.1  ubiquitin-conjugating enzyme E2 D3 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JGL0, Q3U5V6, Q9D1S1
    Conserved Domains (1) summary
    cl00154
    Location:1146
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  4. XM_036163217.1XP_036019110.1  ubiquitin-conjugating enzyme E2 D3 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JGL0, Q3U5V6, Q9D1S1
    Conserved Domains (1) summary
    cl00154
    Location:1146
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  5. XM_036163220.1XP_036019113.1  ubiquitin-conjugating enzyme E2 D3 isoform X2

    UniProtKB/TrEMBL
    A0A494BA56
    Conserved Domains (1) summary
    cl00154
    Location:6110
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...