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SMO smoothened, frizzled class receptor [ Homo sapiens (human) ]

Gene ID: 6608, updated on 5-Dec-2021

Summary

Official Symbol
SMOprovided by HGNC
Official Full Name
smoothened, frizzled class receptorprovided by HGNC
Primary source
HGNC:HGNC:11119
See related
Ensembl:ENSG00000128602 MIM:601500
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Gx; CRJS; PHLS; SMOH; FZD11
Summary
The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex. [provided by RefSeq, Jul 2010]
Expression
Broad expression in ovary (RPKM 15.6), endometrium (RPKM 13.9) and 24 other tissues See more
Orthologs
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Genomic context

See SMO in Genome Data Viewer
Location:
7q32.1
Exon count:
13
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (129188633..129213548)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (128828474..128853386)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase 2 pseudogene Neighboring gene tetraspanin 33 Neighboring gene RNY1 pseudogene 11 Neighboring gene adenosylhomocysteinase like 2 Neighboring gene Sharpr-MPRA regulatory region 5606 Neighboring gene uncharacterized LOC105375500

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables patched binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables patched binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in anterior/posterior pattern specification IEA
Inferred from Electronic Annotation
more info
 
involved_in astrocyte activation IEA
Inferred from Electronic Annotation
more info
 
involved_in atrial septum morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in cell fate specification IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to cholesterol ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in central nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in central nervous system neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cerebellar cortex morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in cerebral cortex development IEA
Inferred from Electronic Annotation
more info
 
involved_in commissural neuron axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in contact inhibition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dentate gyrus development IEA
Inferred from Electronic Annotation
more info
 
involved_in determination of left/right asymmetry in lateral mesoderm ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in dorsal/ventral neural tube patterning IEA
Inferred from Electronic Annotation
more info
 
involved_in epithelial-mesenchymal cell signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in forebrain morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in hair follicle morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in heart looping ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in homeostasis of number of cells within a tissue IEA
Inferred from Electronic Annotation
more info
 
involved_in in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
involved_in left/right axis specification IEA
Inferred from Electronic Annotation
more info
 
involved_in mammary gland epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in mesenchymal to epithelial transition involved in metanephric renal vesicle formation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in midgut development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
involved_in myoblast migration IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of hair follicle development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in neural crest cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in odontogenesis of dentin-containing tooth IEA
Inferred from Electronic Annotation
more info
 
involved_in osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in pancreas morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of branching involved in ureteric bud morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of hh target transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of mesenchymal cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of neuroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of organ growth IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein import into nucleus IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of smoothened signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in protein localization to nucleus IEA
Inferred from Electronic Annotation
more info
 
involved_in protein stabilization IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of heart morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
 
involved_in skeletal muscle fiber development IEA
Inferred from Electronic Annotation
more info
 
involved_in smooth muscle tissue development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in smoothened signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in smoothened signaling pathway IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in smoothened signaling pathway involved in ventral spinal cord patterning IEA
Inferred from Electronic Annotation
more info
 
involved_in somite development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in thalamus development IEA
Inferred from Electronic Annotation
more info
 
involved_in type B pancreatic cell development IEA
Inferred from Electronic Annotation
more info
 
involved_in vasculogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in ventral midline determination ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in 9+0 non-motile cilium IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with caveola IDA
Inferred from Direct Assay
more info
PubMed 
located_in ciliary membrane TAS
Traceable Author Statement
more info
 
located_in ciliary tip TAS
Traceable Author Statement
more info
 
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in cilium ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cilium TAS
Traceable Author Statement
more info
PubMed 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
is_active_in integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
smoothened homolog
Names
frizzled family member 11
protein Gx
seven transmembrane helix receptor
smoothened, frizzled family receptor
smoothened, seven transmembrane spanning receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023340.2 RefSeqGene

    Range
    4762..29674
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1393

mRNA and Protein(s)

  1. NM_005631.5NP_005622.1  smoothened homolog precursor

    See identical proteins and their annotated locations for NP_005622.1

    Status: REVIEWED

    Source sequence(s)
    AC011005
    Consensus CDS
    CCDS5811.1
    UniProtKB/Swiss-Prot
    Q99835
    Related
    ENSP00000249373.3, ENST00000249373.8
    Conserved Domains (2) summary
    cd07451
    Location:66196
    CRD_SMO; Cysteine-rich domain of the smoothened receptor (Smo) integral membrane protein
    pfam01534
    Location:221550
    Frizzled; Frizzled/Smoothened family membrane region

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    129188633..129213548
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446891.1XP_024302659.1  smoothened homolog isoform X1

    Conserved Domains (2) summary
    cd15030
    Location:90420
    7tmF_SMO_homolog; class F smoothened family membrane region, a homolog of frizzled receptors
    cl02447
    Location:166
    CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain
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