U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Chchd3 coiled-coil-helix-coiled-coil-helix domain containing 3 [ Mus musculus (house mouse) ]

Gene ID: 66075, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
Chchd3provided by MGI
Official Full Name
coiled-coil-helix-coiled-coil-helix domain containing 3provided by MGI
Primary source
MGI:MGI:1913325
See related
Ensembl:ENSMUSG00000053768 AllianceGenome:MGI:1913325
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Micos19; 0610041L09Rik; 1700039J09Rik
Summary
Enables molecular adaptor activity. Predicted to be involved in cristae formation and mitochondrial fusion. Located in mitochondrial inner membrane. Is expressed in central nervous system; liver lobe; orbito-sphenoid; retina; and thymus primordium. Orthologous to human CHCHD3 (coiled-coil-helix-coiled-coil-helix domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 56.0), duodenum adult (RPKM 32.6) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Chchd3 in Genome Data Viewer
Location:
6 A3.3; 6 13.97 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (32769142..33037206, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (32792207..33060273, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46956 Neighboring gene predicted gene, 32007 Neighboring gene STARR-seq mESC enhancer starr_15507 Neighboring gene STARR-seq mESC enhancer starr_15508 Neighboring gene STARR-seq mESC enhancer starr_15509 Neighboring gene STARR-seq mESC enhancer starr_15510 Neighboring gene STARR-seq mESC enhancer starr_15513 Neighboring gene STARR-seq mESC enhancer starr_15514 Neighboring gene STARR-seq mESC enhancer starr_15515 Neighboring gene STARR-seq mESC enhancer starr_15516 Neighboring gene predicted gene, 53279 Neighboring gene STARR-positive B cell enhancer ABC_E2190 Neighboring gene STARR-seq mESC enhancer starr_15517 Neighboring gene predicted gene, 22321 Neighboring gene STARR-seq mESC enhancer starr_15518 Neighboring gene STARR-seq mESC enhancer starr_15519 Neighboring gene zinc finger protein 212 pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Identification of ChChd3 as a novel substrate of the cAMP-dependent protein kinase (PKA) using an analog-sensitive catalytic subunit. Schauble S, et al. J Biol Chem, 2007 May 18. PMID 17242405
  2. Targeting and import mechanism of coiled-coil helix coiled-coil helix domain-containing protein 3 (ChChd3) into the mitochondrial intermembrane space. Darshi M, et al. J Biol Chem, 2012 Nov 16. PMID 23019327, Free PMC Article
  3. In-silico QTL mapping of postpubertal mammary ductal development in the mouse uncovers potential human breast cancer risk loci. Hadsell DL, et al. Mamm Genome, 2015 Feb. PMID 25552398, Free PMC Article
  4. ChChd3, an inner mitochondrial membrane protein, is essential for maintaining crista integrity and mitochondrial function. Darshi M, et al. J Biol Chem, 2011 Jan 28. PMID 21081504, Free PMC Article
  5. The protein interactome of collapsin response mediator protein-2 (CRMP2/DPYSL2) reveals novel partner proteins in brain tissue. Martins-de-Souza D, et al. Proteomics Clin Appl, 2015 Oct. PMID 25921334

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mic19 depletion impairs endoplasmic reticulum-mitochondrial contacts and mitochondrial lipid metabolism and triggers liver disease.
    Title: Mic19 depletion impairs endoplasmic reticulum-mitochondrial contacts and mitochondrial lipid metabolism and triggers liver disease.
  2. Liver mitochondrial cristae organizing protein MIC19 promotes energy expenditure and pedestrian locomotion by altering nucleotide metabolism.
    Title: Liver mitochondrial cristae organizing protein MIC19 promotes energy expenditure and pedestrian locomotion by altering nucleotide metabolism.
  3. ChChd3 is a scaffolding protein that stabilizes protein complexes involved in maintaining crista architecture and protein import and is thus essential for maintaining mitochondrial structure and function.
    Title: ChChd3, an inner mitochondrial membrane protein, is essential for maintaining crista integrity and mitochondrial function.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Transgenic (1) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular adaptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatase binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cristae formation IEA
Inferred from Electronic Annotation
more info
  
involved_in cristae formation ISO
Inferred from Sequence Orthology
more info
  
involved_in inner mitochondrial membrane organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inner mitochondrial membrane organization ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial fusion IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial fusion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of MICOS complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MICOS complex IEA
Inferred from Electronic Annotation
more info
  
part_of MICOS complex ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
MICOS complex subunit Mic19
Names
coiled-coil-helix-coiled-coil-helix domain-containing protein 3, mitochondrial

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355667.1 → NP_001342596.1  MICOS complex subunit Mic19

    Status: VALIDATED

    Source sequence(s)
    AC152943, AC156288
    UniProtKB/TrEMBL
    D3Z0L4
    Related
    ENSMUSP00000123220.2, ENSMUST00000127666.8
    Conserved Domains (1) summary
    pfam05300
    Location:15 → 180
    DUF737; Protein of unknown function (DUF737)

  2. NM_025336.2 → NP_079612.1  MICOS complex subunit Mic19

    See identical proteins and their annotated locations for NP_079612.1

    Status: VALIDATED

    Source sequence(s)
    AC152943, AC156288
    Consensus CDS
    CCDS19986.1
    UniProtKB/Swiss-Prot
    Q9CRB9
    UniProtKB/TrEMBL
    Q91VG6
    Related
    ENSMUSP00000070149.5, ENSMUST00000066379.11
    Conserved Domains (1) summary
    pfam05300
    Location:15 → 175
    DUF737; Protein of unknown function (DUF737)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    32769142..33037206 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152261.1 → XP_036008154.1  MICOS complex subunit Mic19 isoform X2

    Related
    ENSMUSP00000110743.2, ENSMUST00000115091.2
    Conserved Domains (1) summary
    pfam05300
    Location:20 → 151
    DUF737; Protein of unknown function (DUF737)

  2. XM_006506468.5 → XP_006506531.1  MICOS complex subunit Mic19 isoform X1

    Conserved Domains (1) summary
    pfam05300
    Location:15 → 156
    DUF737; Protein of unknown function (DUF737)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CRB9.1 GenPept UniProtKB/Swiss-Prot:Q9CRB9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools