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Cwc15 CWC15 spliceosome-associated protein [ Mus musculus (house mouse) ]

Gene ID: 66070, updated on 8-Feb-2024

Summary

Official Symbol
Cwc15provided by MGI
Official Full Name
CWC15 spliceosome-associated proteinprovided by MGI
Primary source
MGI:MGI:1913320
See related
Ensembl:ENSMUSG00000004096 AllianceGenome:MGI:1913320
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ed1; mED1; c11orf5; 0610040D20Rik; 2900052N06Rik
Summary
Predicted to enable RNA binding activity. Predicted to be involved in mRNA cis splicing, via spliceosome. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in mitochondrion and nuclear speck. Predicted to be part of U2-type catalytic step 2 spliceosome. Orthologous to human CWC15 (CWC15 spliceosome associated protein homolog). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 41.8), bladder adult (RPKM 30.3) and 22 other tissues See more
Orthologs
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Genomic context

See Cwc15 in Genome Data Viewer
Location:
9 A2; 9 4.09 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (14411876..14421920)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (14500604..14510620)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_23348 Neighboring gene lysine (K)-specific demethylase 4D-like Neighboring gene lysine (K)-specific demethylase 4D Neighboring gene STARR-positive B cell enhancer ABC_E248 Neighboring gene angiomotin-like 1 Neighboring gene predicted gene, 34263 Neighboring gene predicted gene 7607

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA cis splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
involved_in mRNA splicing, via spliceosome NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of Prp19 complex ISO
Inferred from Sequence Orthology
more info
 
part_of U2-type catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
 
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of spliceosomal complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
spliceosome-associated protein CWC15 homolog
Names
CWC15 homolog
embryonic development factor 1
nucleoporin
protein CWC15 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023153.3NP_075642.1  spliceosome-associated protein CWC15 homolog

    See identical proteins and their annotated locations for NP_075642.1

    Status: VALIDATED

    Source sequence(s)
    AK002864, BQ840384, CT485607
    Consensus CDS
    CCDS22823.1
    UniProtKB/Swiss-Prot
    Q3TH98, Q9CTH0, Q9JHS9
    Related
    ENSMUSP00000004200.9, ENSMUST00000004200.9
    Conserved Domains (1) summary
    pfam04889
    Location:1228
    Cwf_Cwc_15; Cwf15/Cwc15 cell cycle control protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    14411876..14421920
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510537.4XP_006510600.1  spliceosome-associated protein CWC15 homolog isoform X1

    See identical proteins and their annotated locations for XP_006510600.1

    UniProtKB/Swiss-Prot
    Q3TH98, Q9CTH0, Q9JHS9
    Related
    ENSMUSP00000149476.2, ENSMUST00000213913.2
    Conserved Domains (1) summary
    pfam04889
    Location:1228
    Cwf_Cwc_15; Cwf15/Cwc15 cell cycle control protein