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Ndufb5 NADH:ubiquinone oxidoreductase subunit B5 [ Mus musculus (house mouse) ]

Gene ID: 66046, updated on 3-Nov-2024

Summary

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Official Symbol
Ndufb5provided by MGI
Official Full Name
NADH:ubiquinone oxidoreductase subunit B5provided by MGI
Primary source
MGI:MGI:1913296
See related
Ensembl:ENSMUSG00000027673 AllianceGenome:MGI:1913296
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SGDH; CI-SGDH; 0610007D05Rik
Summary
Predicted to be involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrial inner membrane. Is expressed in pancreas epithelium. Orthologous to human NDUFB5 (NADH:ubiquinone oxidoreductase subunit B5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in heart adult (RPKM 156.3), adrenal adult (RPKM 105.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ndufb5 in Genome Data Viewer
Location:
3 A3; 3 15.85 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (32791206..32805708)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (32737057..32751559)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E179 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:32635708-32635977 Neighboring gene actin-like 6A Neighboring gene STARR-seq mESC enhancer starr_07351 Neighboring gene mitochondrial ribosomal protein L47 Neighboring gene ubiquitin specific peptidase 13 (isopeptidase T-3) Neighboring gene peroxisomal biogenesis factor 5-like Neighboring gene predicted gene, 23214

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. METTL3-mediated NDUFB5 m6A modification promotes cell migration and mitochondrial respiration to promote the wound healing of diabetic foot ulcer. Wang T, et al. J Transl Med, 2024 Jul 9. PMID 38982516, Free PMC Article
  2. Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function. Yavari A, et al. Cell Metab, 2016 May 10. PMID 27133129, Free PMC Article
  3. Mitofusins 1 and 2 are essential for postnatal metabolic remodeling in heart. Papanicolaou KN, et al. Circ Res, 2012 Sep 28. PMID 22904094, Free PMC Article
  4. Region-specific expression of mitochondrial complex I genes during murine brain development. Wirtz S, et al. PLoS One, 2011 Apr 27. PMID 21556144, Free PMC Article
  5. Cfp1 Controls Cardiomyocyte Maturation by Modifying Histone H3K4me3 of Structural, Metabolic, and Contractile Related Genes. Li C, et al. Adv Sci (Weinh), 2024 Mar. PMID 38196272, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. METTL3-mediated NDUFB5 m6A modification promotes cell migration and mitochondrial respiration to promote the wound healing of diabetic foot ulcer.
    Title: METTL3-mediated NDUFB5 m6A modification promotes cell migration and mitochondrial respiration to promote the wound healing of diabetic foot ulcer.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in aerobic respiration NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mitochondrial respiratory chain complex I assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial respiratory chain complex I assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proton motive force-driven mitochondrial ATP synthesis NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of respiratory chain complex I IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of respiratory chain complex I ISO
Inferred from Sequence Orthology
more info
  
part_of respiratory chain complex I ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial
Names
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5
NADH-ubiquinone oxidoreductase SGDH subunit
complex I-SGDH
NP_079592.2
XP_006535577.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025316.2 → NP_079592.2  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial precursor

    See identical proteins and their annotated locations for NP_079592.2

    Status: VALIDATED

    Source sequence(s)
    AK004372
    Consensus CDS
    CCDS17300.1
    UniProtKB/Swiss-Prot
    Q9CQH3
    UniProtKB/TrEMBL
    Q8BU20
    Related
    ENSMUSP00000114963.2, ENSMUST00000127477.8
    Conserved Domains (1) summary
    pfam09781
    Location:1 → 188
    NDUF_B5; NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    32791206..32805708
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535514.3 → XP_006535577.1  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006535577.1

    UniProtKB/TrEMBL
    D3Z568
    Related
    ENSMUSP00000113602.2, ENSMUST00000122290.2
    Conserved Domains (1) summary
    pfam09781
    Location:1 → 118
    NDUF_B5; NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQH3.1 GenPept UniProtKB/Swiss-Prot:Q9CQH3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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