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FUNDC2 FUN14 domain containing 2 [ Homo sapiens (human) ]

Gene ID: 65991, updated on 8-Jan-2023

Summary

Official Symbol
FUNDC2provided by HGNC
Official Full Name
FUN14 domain containing 2provided by HGNC
Primary source
HGNC:HGNC:24925
See related
Ensembl:ENSG00000165775 MIM:301042; AllianceGenome:HGNC:24925
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DC44; HCC3; HCBP6; PD03104
Summary
Predicted to be involved in autophagy of mitochondrion. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart (RPKM 26.0), ovary (RPKM 19.3) and 25 other tissues See more
Orthologs
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Genomic context

See FUNDC2 in Genome Data Viewer
Location:
Xq28
Exon count:
5
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (155026844..155060304)
110 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (153263246..153296709)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (154255119..154288579)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene coagulation factor VIII Neighboring gene ZNF622 pseudogene 1 Neighboring gene int1h-1 recombination region Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:154285543-154286044 Neighboring gene mature T cell proliferation 1 Neighboring gene C-X9-C motif containing 4 Neighboring gene BRCA1/BRCA2-containing complex subunit 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC2495, FLJ33773, MGC131676

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in autophagy of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intracellular triglyceride homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of platelet activation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 
located_in nucleus HDA PubMed 

General protein information

Preferred Names
FUN14 domain-containing protein 2
Names
HCC-3
cervical cancer oncogene 3
cervical cancer proto-oncogene 3 protein
hepatitis C virus core-binding protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023934.4NP_076423.2  FUN14 domain-containing protein 2

    See identical proteins and their annotated locations for NP_076423.2

    Status: VALIDATED

    Source sequence(s)
    AF320778, AI886036, BI463291, BM713884, BU738737, BX470111, CN306694
    Consensus CDS
    CCDS14763.1
    UniProtKB/Swiss-Prot
    Q9BWH2, Q9H2I6
    Related
    ENSP00000358510.3, ENST00000369498.8
    Conserved Domains (1) summary
    pfam04930
    Location:87173
    FUN14; FUN14 family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    155026844..155060304
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    153263246..153296709
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)