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SLCO1A2 solute carrier organic anion transporter family member 1A2 [ Homo sapiens (human) ]

Gene ID: 6579, updated on 26-Sep-2021

Summary

Official Symbol
SLCO1A2provided by HGNC
Official Full Name
solute carrier organic anion transporter family member 1A2provided by HGNC
Primary source
HGNC:HGNC:10956
See related
Ensembl:ENSG00000084453 MIM:602883
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OATP; OATP-A; OATP1A2; SLC21A3
Summary
This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its substrates include bile acids, bromosulphophthalein, and some steroidal compounds. The protein is a member of the SLC21A family of solute carriers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2008]
Expression
Biased expression in brain (RPKM 6.2), lung (RPKM 0.9) and 2 other tissues See more
Orthologs
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Genomic context

See SLCO1A2 in Genome Data Viewer
Location:
12p12.1
Exon count:
31
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (21264600..21419634, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (21417534..21572568, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene SLCO1B3-SLCO1B7 readthrough Neighboring gene solute carrier organic anion transporter family member 1B3 Neighboring gene solute carrier organic anion transporter family member 1B1 Neighboring gene islet amyloid polypeptide Neighboring gene pyridine nucleotide-disulphide oxidoreductase domain 1 Neighboring gene elongin C pseudogene 31 Neighboring gene RecQ like helicase Neighboring gene golgi transport 1B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association meta-analysis for total serum bilirubin levels.
GeneReviews: Not available
Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects.
GeneReviews: Not available
Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in bile acid and bile salt transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in bile acid and bile salt transport TAS
Traceable Author Statement
more info
 
involved_in organic anion transport TAS
Traceable Author Statement
more info
PubMed 
involved_in sodium-independent organic anion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in sodium-independent organic anion transport TAS
Traceable Author Statement
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
solute carrier organic anion transporter family member 1A2
Names
OATP-1
organic anion transporting polypeptide A
organic anion-transporting polypeptide 1
sodium-independent organic anion transporter
solute carrier family 21 (organic anion transporter), member 3
solute carrier family 21 member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001386878.1NP_001373807.1  solute carrier organic anion transporter family member 1A2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC006559, AC022224
    Conserved Domains (1) summary
    TIGR00805
    Location:1625
    oat; sodium-independent organic anion transporter
  2. NM_001386879.1NP_001373808.1  solute carrier organic anion transporter family member 1A2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC022224
    Related
    ENSP00000508235.1, ENST00000683939.1
    Conserved Domains (1) summary
    TIGR00805
    Location:1625
    oat; sodium-independent organic anion transporter
  3. NM_001386880.1NP_001373809.1  solute carrier organic anion transporter family member 1A2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC022224
    Conserved Domains (1) summary
    TIGR00805
    Location:1625
    oat; sodium-independent organic anion transporter
  4. NM_001386881.1NP_001373810.1  solute carrier organic anion transporter family member 1A2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC006559, AC022224
    Conserved Domains (1) summary
    TIGR00805
    Location:1625
    oat; sodium-independent organic anion transporter
  5. NM_001386882.2NP_001373811.1  solute carrier organic anion transporter family member 1A2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC022224
    Conserved Domains (1) summary
    TIGR00805
    Location:1625
    oat; sodium-independent organic anion transporter
  6. NM_001386886.1NP_001373815.1  solute carrier organic anion transporter family member 1A2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC022224
    Conserved Domains (1) summary
    cl28910
    Location:18536
    MFS; Major Facilitator Superfamily
  7. NM_001386887.1NP_001373816.1  solute carrier organic anion transporter family member 1A2 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC022224
    Conserved Domains (1) summary
    cl28910
    Location:18538
    MFS; Major Facilitator Superfamily
  8. NM_001386890.1NP_001373819.1  solute carrier organic anion transporter family member 1A2 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC022224
    Conserved Domains (1) summary
    TIGR00805
    Location:1469
    oat; sodium-independent organic anion transporter
  9. NM_001386908.1NP_001373837.1  solute carrier organic anion transporter family member 1A2 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC022224
    Conserved Domains (1) summary
    TIGR00805
    Location:1538
    oat; sodium-independent organic anion transporter
  10. NM_001386919.1NP_001373848.1  solute carrier organic anion transporter family member 1A2 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC022224
    Conserved Domains (1) summary
    TIGR00805
    Location:1538
    oat; sodium-independent organic anion transporter
  11. NM_001386920.1NP_001373849.1  solute carrier organic anion transporter family member 1A2 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC022224
    Conserved Domains (1) summary
    TIGR00805
    Location:1469
    oat; sodium-independent organic anion transporter
  12. NM_001386921.1NP_001373850.1  solute carrier organic anion transporter family member 1A2 isoform 10 precursor

    Status: REVIEWED

    Source sequence(s)
    AC022224
    Conserved Domains (1) summary
    TIGR00805
    Location:1525
    oat; sodium-independent organic anion transporter
  13. NM_001386922.1NP_001373851.1  solute carrier organic anion transporter family member 1A2 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC022224
    Conserved Domains (1) summary
    TIGR00805
    Location:1493
    oat; sodium-independent organic anion transporter
  14. NM_001386926.1NP_001373855.1  solute carrier organic anion transporter family member 1A2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC022224
    Conserved Domains (1) summary
    cl28910
    Location:18536
    MFS; Major Facilitator Superfamily
  15. NM_001386927.1NP_001373856.1  solute carrier organic anion transporter family member 1A2 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC022224
    Conserved Domains (1) summary
    TIGR00805
    Location:1538
    oat; sodium-independent organic anion transporter
  16. NM_001386929.1NP_001373858.1  solute carrier organic anion transporter family member 1A2 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC022224
    Conserved Domains (1) summary
    TIGR00805
    Location:1493
    oat; sodium-independent organic anion transporter
  17. NM_001386931.1NP_001373860.1  solute carrier organic anion transporter family member 1A2 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC022224
    Conserved Domains (1) summary
    TIGR00805
    Location:1469
    oat; sodium-independent organic anion transporter
  18. NM_001386937.1NP_001373866.1  solute carrier organic anion transporter family member 1A2 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC006559, AC022224
    Conserved Domains (1) summary
    TIGR00805
    Location:1493
    oat; sodium-independent organic anion transporter
  19. NM_001386938.1NP_001373867.1  solute carrier organic anion transporter family member 1A2 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC022224
    Related
    ENSP00000394854.1, ENST00000458504.5
    Conserved Domains (1) summary
    TIGR00805
    Location:1493
    oat; sodium-independent organic anion transporter
  20. NM_001386939.1NP_001373868.1  solute carrier organic anion transporter family member 1A2 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC022224
    Conserved Domains (1) summary
    TIGR00805
    Location:1493
    oat; sodium-independent organic anion transporter
  21. NM_001386940.1NP_001373869.1  solute carrier organic anion transporter family member 1A2 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC022224
    Conserved Domains (1) summary
    TIGR00805
    Location:1493
    oat; sodium-independent organic anion transporter
  22. NM_001386946.1NP_001373875.1  solute carrier organic anion transporter family member 1A2 isoform 7 precursor

    Status: REVIEWED

    Source sequence(s)
    AC022224
    Conserved Domains (1) summary
    cl28910
    Location:1518
    MFS; Major Facilitator Superfamily
  23. NM_001386947.1NP_001373876.1  solute carrier organic anion transporter family member 1A2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC022224
    Conserved Domains (1) summary
    cl28910
    Location:18536
    MFS; Major Facilitator Superfamily
  24. NM_001386948.1NP_001373877.1  solute carrier organic anion transporter family member 1A2 isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AC022224
    Conserved Domains (1) summary
    cl28910
    Location:1518
    MFS; Major Facilitator Superfamily
  25. NM_001386949.1NP_001373878.1  solute carrier organic anion transporter family member 1A2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC022224
    Conserved Domains (1) summary
    cl28910
    Location:18536
    MFS; Major Facilitator Superfamily
  26. NM_001386951.1NP_001373880.1  solute carrier organic anion transporter family member 1A2 isoform 6 precursor

    Status: REVIEWED

    Source sequence(s)
    AC022224
    Conserved Domains (1) summary
    cl28910
    Location:1517
    MFS; Major Facilitator Superfamily
  27. NM_001386952.1NP_001373881.1  solute carrier organic anion transporter family member 1A2 isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AC022224
    Conserved Domains (1) summary
    cl28910
    Location:1518
    MFS; Major Facilitator Superfamily
  28. NM_001386953.1NP_001373882.1  solute carrier organic anion transporter family member 1A2 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC022224
    Conserved Domains (1) summary
    TIGR00805
    Location:1469
    oat; sodium-independent organic anion transporter
  29. NM_001386954.1NP_001373883.1  solute carrier organic anion transporter family member 1A2 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC022224
    Conserved Domains (1) summary
    TIGR00805
    Location:1469
    oat; sodium-independent organic anion transporter
  30. NM_001386958.1NP_001373887.1  solute carrier organic anion transporter family member 1A2 isoform 5 precursor

    Status: REVIEWED

    Source sequence(s)
    AC022224
    Conserved Domains (1) summary
    cl28910
    Location:1518
    MFS; Major Facilitator Superfamily
  31. NM_001386959.1NP_001373888.1  solute carrier organic anion transporter family member 1A2 isoform 9 precursor

    Status: REVIEWED

    Source sequence(s)
    AC022224
    Conserved Domains (1) summary
    cl28910
    Location:1518
    MFS; Major Facilitator Superfamily
  32. NM_001386960.1NP_001373889.1  solute carrier organic anion transporter family member 1A2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC022224
    Conserved Domains (1) summary
    cl28910
    Location:18536
    MFS; Major Facilitator Superfamily
  33. NM_001386961.1NP_001373890.1  solute carrier organic anion transporter family member 1A2 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC022224
    Conserved Domains (1) summary
    TIGR00805
    Location:1469
    oat; sodium-independent organic anion transporter
  34. NM_001386962.1NP_001373891.1  solute carrier organic anion transporter family member 1A2 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC022224
    Conserved Domains (1) summary
    TIGR00805
    Location:1493
    oat; sodium-independent organic anion transporter
  35. NM_001386963.1NP_001373892.1  solute carrier organic anion transporter family member 1A2 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC022224
    Conserved Domains (1) summary
    cl28910
    Location:1451
    MFS; Major Facilitator Superfamily
  36. NM_021094.4NP_066580.1  solute carrier organic anion transporter family member 1A2 isoform 1

    See identical proteins and their annotated locations for NP_066580.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. The translation of this protein may be modulated by multiple upstream ORFs that are present in the 5' UTR.
    Source sequence(s)
    AC022224, BX093727, DA216595, U21943
    Consensus CDS
    CCDS8686.1
    UniProtKB/Swiss-Prot
    P46721
    UniProtKB/TrEMBL
    A0A024RAT5
    Conserved Domains (1) summary
    TIGR00805
    Location:1625
    oat; sodium-independent organic anion transporter
  37. NM_134431.5NP_602307.1  solute carrier organic anion transporter family member 1A2 isoform 1

    See identical proteins and their annotated locations for NP_602307.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. The translation of this protein may be modulated by multiple upstream ORFs that are present in the 5' UTR.
    Source sequence(s)
    AC006559, AC022224
    Consensus CDS
    CCDS8686.1
    UniProtKB/Swiss-Prot
    P46721
    UniProtKB/TrEMBL
    A0A024RAT5
    Related
    ENSP00000305974.6, ENST00000307378.10
    Conserved Domains (1) summary
    TIGR00805
    Location:1625
    oat; sodium-independent organic anion transporter

RNA

  1. NR_170340.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC022224
  2. NR_170341.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC022224
  3. NR_170343.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC022224
    Related
    ENST00000480394.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    21264600..21419634 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011520819.1XP_011519121.1  solute carrier organic anion transporter family member 1A2 isoform X1

    See identical proteins and their annotated locations for XP_011519121.1

    UniProtKB/Swiss-Prot
    P46721
    UniProtKB/TrEMBL
    A0A024RAT5
    Conserved Domains (1) summary
    TIGR00805
    Location:1625
    oat; sodium-independent organic anion transporter
  2. XM_024449138.1XP_024304906.1  solute carrier organic anion transporter family member 1A2 isoform X1

    Conserved Domains (1) summary
    TIGR00805
    Location:1625
    oat; sodium-independent organic anion transporter
  3. XM_011520821.2XP_011519123.1  solute carrier organic anion transporter family member 1A2 isoform X6

    Conserved Domains (1) summary
    cd01330
    Location:127180
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
  4. XM_017019849.1XP_016875338.1  solute carrier organic anion transporter family member 1A2 isoform X4

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_005075.2: Suppressed sequence

    Description
    NM_005075.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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