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Defb47 defensin beta 47 [ Mus musculus (house mouse) ]

Gene ID: 654465, updated on 17-Aug-2024

Summary

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Official Symbol
Defb47provided by MGI
Official Full Name
defensin beta 47provided by MGI
Primary source
MGI:MGI:3644478
See related
Ensembl:ENSMUSG00000075573 AllianceGenome:MGI:3644478
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Defb41; EG654465
Summary
Predicted to enable CCR6 chemokine receptor binding activity and chemoattractant activity. Predicted to be involved in cell chemotaxis and defense response to bacterium. Predicted to be located in cytosol. Predicted to be active in extracellular space. Is expressed in ductus deferens; prostate gland; and testis. Orthologous to human DEFB130A (defensin beta 130A) and DEFB130B (defensin beta 130B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward genital fat pad adult (RPKM 298.3) See more
Orthologs
human all
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Genomic context

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See Defb47 in Genome Data Viewer
Location:
14 D1; 14 33.23 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (63229824..63238629)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (62992375..63001180)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene deubiquitinating enzyme 1 pseudogene Neighboring gene defensin beta 48 Neighboring gene defensin beta 43 Neighboring gene nuclear undecaprenyl pyrophosphate synthase 1 homolog pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract. Patil AA, et al. Physiol Genomics, 2005 Sep 21. PMID 16033865
  2. Manual annotation and analysis of the defensin gene cluster in the C57BL/6J mouse reference genome. Amid C, et al. BMC Genomics, 2009 Dec 15. PMID 20003482, Free PMC Article
  3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables CCR6 chemokine receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chemoattractant activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to bacterium IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
beta-defensin 130B
Names
defensin beta 41

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039125.2 → NP_001034214.1  beta-defensin 130B precursor

    See identical proteins and their annotated locations for NP_001034214.1

    Status: VALIDATED

    Source sequence(s)
    BC132604
    Consensus CDS
    CCDS36945.1
    UniProtKB/TrEMBL
    Q30KN1
    Related
    ENSMUSP00000098061.4, ENSMUST00000100492.5

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    63229824..63238629
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247915.1 → XP_030103775.1  beta-defensin 130B isoform X1

    UniProtKB/TrEMBL
    Q30KN1

  2. XM_030247916.1 → XP_030103776.1  beta-defensin 130B isoform X1

    UniProtKB/TrEMBL
    Q30KN1

  3. XM_017316118.2 → XP_017171607.1  beta-defensin 130B isoform X1

    UniProtKB/TrEMBL
    Q30KN1
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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