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LGALS9C galectin 9C [ Homo sapiens (human) ]

Gene ID: 654346, updated on 11-Jun-2021

Summary

Official Symbol
LGALS9Cprovided by HGNC
Official Full Name
galectin 9Cprovided by HGNC
Primary source
HGNC:HGNC:33874
See related
Ensembl:ENSG00000171916
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Gal-9B; LGALS9B
Summary
This gene was initially thought to represent a pseudogene of galectin 9; however, this transcript has good exon-intron structure and encodes a predicted protein of the same size as and highly similar to galectin 9. This gene is one of two similar loci on chromosome 17p similar to galectin 9 and now thought to be protein-encoding. This gene is the more telomeric gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in stomach (RPKM 22.9), gall bladder (RPKM 8.6) and 4 other tissues See more
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Genomic context

See LGALS9C in Genome Data Viewer
Location:
17p11.2
Exon count:
12
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (18476785..18494945)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (18380103..18398259)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene keratin 16 pseudogene 4 Neighboring gene transportin 1 pseudogene 2 Neighboring gene nitric oxide synthase 2 pseudogene 2 Neighboring gene ubiquitin specific peptidase 32 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC125972

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carbohydrate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables galactoside binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in negative regulation of CD4-positive, alpha-beta T cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of interferon-gamma production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
galectin-9C
Names
Galectin-9-like protein A
Galectin-9B
gal-9C
galectin 9 like
galectin-9-like protein B
lectin, galactoside-binding, soluble, 9 (galectin 9) pseudogene
lectin, galactoside-binding, soluble, 9C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040078.3NP_001035167.2  galectin-9C

    See identical proteins and their annotated locations for NP_001035167.2

    Status: VALIDATED

    Source sequence(s)
    BC073889, BM769737, DA426549
    Consensus CDS
    CCDS32587.1
    UniProtKB/Swiss-Prot
    Q6DKI2
    Related
    ENSP00000329932.6, ENST00000328114.11
    Conserved Domains (2) summary
    smart00908
    Location:233355
    Gal-bind_lectin; Galactoside-binding lectin
    cd00070
    Location:16146
    GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    18476785..18494945
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011523993.1XP_011522295.1  galectin-9C isoform X2

    Conserved Domains (2) summary
    smart00908
    Location:201323
    Gal-bind_lectin; Galactoside-binding lectin
    cd00070
    Location:16146
    GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...
  2. XM_005256770.1XP_005256827.1  galectin-9C isoform X3

    UniProtKB/TrEMBL
    J3KSY2
    Related
    ENSP00000462708.1, ENST00000583322.5
    Conserved Domains (2) summary
    smart00908
    Location:200322
    Gal-bind_lectin; Galactoside-binding lectin
    cd00070
    Location:16146
    GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...
  3. XM_024450891.1XP_024306659.1  galectin-9C isoform X8

    Related
    ENSP00000464108.1, ENST00000581545.5
    Conserved Domains (2) summary
    cd00070
    Location:16146
    GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...
    cl00071
    Location:194221
    GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...
  4. XM_011523994.1XP_011522296.1  galectin-9C isoform X4

    Conserved Domains (2) summary
    smart00908
    Location:189311
    Gal-bind_lectin; Galactoside-binding lectin
    cd00070
    Location:16146
    GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...
  5. XM_011523995.2XP_011522297.1  galectin-9C isoform X5

    Conserved Domains (2) summary
    cd00070
    Location:16146
    GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...
    cl00071
    Location:227254
    GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...
  6. XM_005256769.2XP_005256826.1  galectin-9C isoform X1

    Conserved Domains (2) summary
    smart00908
    Location:232354
    Gal-bind_lectin; Galactoside-binding lectin
    cd00070
    Location:16146
    GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...
  7. XM_011523996.1XP_011522298.1  galectin-9C isoform X6

    Conserved Domains (1) summary
    smart00908
    Location:145267
    Gal-bind_lectin; Galactoside-binding lectin
  8. XM_011523997.1XP_011522299.1  galectin-9C isoform X7

    Conserved Domains (2) summary
    smart00908
    Location:130252
    Gal-bind_lectin; Galactoside-binding lectin
    cl00071
    Location:843
    GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_017363819.1 Reference GRCh38.p13 PATCHES

    Range
    246768..264924
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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