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TRIM43B tripartite motif containing 43B [ Homo sapiens (human) ]

Gene ID: 653192, updated on 26-Oct-2022

Summary

Official Symbol
TRIM43Bprovided by HGNC
Official Full Name
tripartite motif containing 43Bprovided by HGNC
Primary source
HGNC:HGNC:37146
See related
Ensembl:ENSG00000144010 AllianceGenome:HGNC:37146
Gene type
protein coding
RefSeq status
INFERRED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response; protein ubiquitination; and regulation of gene expression. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
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Genomic context

See TRIM43B in Genome Data Viewer
Location:
2q11.1
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (95477008..95484754, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (95983491..95991236, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (96142756..96150502, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene UBTF like 5 (pseudogene) Neighboring gene cAMP responsive element binding protein 1 pseudogene Neighboring gene tripartite motif containing 64F, pseudogene Neighboring gene ANKRD33B pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
tripartite motif-containing protein 43B
Names
tripartite motif-containing protein 43-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164464.2NP_001157936.1  tripartite motif-containing protein 43B

    See identical proteins and their annotated locations for NP_001157936.1

    Status: INFERRED

    Source sequence(s)
    AC009237
    Consensus CDS
    CCDS92808.1
    UniProtKB/Swiss-Prot
    A6NCK2
    Related
    ENSP00000492719.1, ENST00000639673.3
    Conserved Domains (3) summary
    cl02614
    Location:284441
    SPRY; SPRY domain
    cl17238
    Location:1555
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cl23765
    Location:131259
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    95477008..95484754 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511669.2XP_011509971.1  tripartite motif-containing protein 43B isoform X1

    Conserved Domains (3) summary
    cl02614
    Location:294451
    SPRY; SPRY domain
    cl17238
    Location:2565
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cl23765
    Location:141269
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791760.1 Reference GRCh38.p14 PATCHES

    Range
    354223..361971
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    95983491..95991236 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)