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NADK NAD kinase [ Homo sapiens (human) ]

Gene ID: 65220, updated on 18-May-2019

Summary

Official Symbol
NADKprovided by HGNC
Official Full Name
NAD kinaseprovided by HGNC
Primary source
HGNC:HGNC:29831
See related
Ensembl:ENSG00000008130 MIM:611616
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
dJ283E3.1
Summary
NADK catalyzes the transfer of a phosphate group from ATP to NAD to generate NADP, which in its reduced form acts as an electron donor for biosynthetic reactions (Lerner et al., 2001 [PubMed 11594753]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 24.4), spleen (RPKM 23.0) and 25 other tissues See more
Orthologs

Genomic context

See NADK in Genome Data Viewer
Location:
1p36.33
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (1751232..1780509, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (1682671..1711508, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene cyclin dependent kinase 11A Neighboring gene ribosomal protein S7 pseudogene Neighboring gene solute carrier family 35 member E2A Neighboring gene uncharacterized LOC112268218 Neighboring gene G protein subunit beta 1 Neighboring gene collagen alpha-2(VIII) chain Neighboring gene calmodulin like 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC1900, FLJ13052, FLJ37724, FLJ54695, FLJ77769, FLJ78247, FLJ78307, DKFZp686L22239

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
NAD+ kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NAD+ kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
ATP metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
NAD metabolic process TAS
Traceable Author Statement
more info
 
NADP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphorylation NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of insulin secretion involved in cellular response to glucose stimulus IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
NAD kinase
Names
poly(P)/ATP NAD kinase
NP_001185922.1
NP_001185923.1
NP_001185924.1
NP_001340570.1
NP_001340571.1
NP_075394.3
XP_006710902.1
XP_011540308.1
XP_011540309.1
XP_011540310.1
XP_011540311.1
XP_016857632.1
XP_016857633.1
XP_016857634.1
XP_016857635.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198993.1NP_001185922.1  NAD kinase isoform 1

    See identical proteins and their annotated locations for NP_001185922.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR compared to variant 1. Variants 1, 2 and 5 encode the same isoform (1).
    Source sequence(s)
    AL031282, BC001709, BC024219, BM842058, CN349189
    Consensus CDS
    CCDS30565.1
    UniProtKB/Swiss-Prot
    O95544
    UniProtKB/TrEMBL
    A0A024R058, Q6PJ22
    Related
    ENSP00000344340.3, ENST00000341991.7
    Conserved Domains (1) summary
    cl28462
    Location:96433
    pnk; inorganic polyphosphate/ATP-NAD kinase; Provisional
  2. NM_001198994.1NP_001185923.1  NAD kinase isoform 2

    See identical proteins and their annotated locations for NP_001185923.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and CDS compared to variant 1. The resulting isoform (2) has two additional internal segments, as compared to isoform 1.
    Source sequence(s)
    AF250320, AL031282, BC001709, BM842058
    Consensus CDS
    CCDS55562.1
    UniProtKB/Swiss-Prot
    O95544
    Related
    ENSP00000367890.1, ENST00000378625.5
    Conserved Domains (1) summary
    cl01255
    Location:202578
    DAGK_cat; Diacylglycerol kinase catalytic domain
  3. NM_001198995.1NP_001185924.1  NAD kinase isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks three exons from the 5' end and has an alternate 5' exon compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus, as compared to isoform 1.
    Source sequence(s)
    AK296722, AL031282, BC001709, BM842058
    Consensus CDS
    CCDS55561.1
    UniProtKB/Swiss-Prot
    O95544
    UniProtKB/TrEMBL
    A0A0A0MR98
    Related
    ENSP00000339727.5, ENST00000342348.9
    Conserved Domains (1) summary
    cl01255
    Location:66401
    DAGK_cat; Diacylglycerol kinase catalytic domain
  4. NM_001353641.1NP_001340570.1  NAD kinase isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 5 encode the same isoform (1).
    Source sequence(s)
    AL031282
    Consensus CDS
    CCDS30565.1
    Conserved Domains (1) summary
    cl28462
    Location:96433
    pnk; inorganic polyphosphate/ATP-NAD kinase; Provisional
  5. NM_001353642.1NP_001340571.1  NAD kinase isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses and alternate splice site which results in the use of an alternate start codon compared to variant 1. The encoded isoform (4) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AL031282
    Conserved Domains (1) summary
    cl28462
    Location:9346
    pnk; inorganic polyphosphate/ATP-NAD kinase; Provisional
  6. NM_023018.5NP_075394.3  NAD kinase isoform 1

    See identical proteins and their annotated locations for NP_075394.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes variant 1 isoform (1). Variants 1, 2 and 5 encode the same isoform (1).
    Source sequence(s)
    AK023114, AL031282, BC001709, BM842058
    Consensus CDS
    CCDS30565.1
    UniProtKB/Swiss-Prot
    O95544
    UniProtKB/TrEMBL
    A0A024R058
    Related
    ENSP00000341679.5, ENST00000341426.9
    Conserved Domains (1) summary
    cl28462
    Location:96433
    pnk; inorganic polyphosphate/ATP-NAD kinase; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    1751232..1780509 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006710839.2XP_006710902.1  NAD kinase isoform X5

    Conserved Domains (1) summary
    cl01255
    Location:202537
    DAGK_cat; Diacylglycerol kinase catalytic domain
  2. XM_011542007.2XP_011540309.1  NAD kinase isoform X2

    See identical proteins and their annotated locations for XP_011540309.1

    Conserved Domains (1) summary
    cl01255
    Location:68330
    DAGK_cat; Diacylglycerol kinase catalytic domain
  3. XM_017002143.2XP_016857632.1  NAD kinase isoform X1

  4. XM_011542009.2XP_011540311.1  NAD kinase isoform X2

    See identical proteins and their annotated locations for XP_011540311.1

    Conserved Domains (1) summary
    cl01255
    Location:68330
    DAGK_cat; Diacylglycerol kinase catalytic domain
  5. XM_011542008.1XP_011540310.1  NAD kinase isoform X2

    See identical proteins and their annotated locations for XP_011540310.1

    Conserved Domains (1) summary
    cl01255
    Location:68330
    DAGK_cat; Diacylglycerol kinase catalytic domain
  6. XM_017002146.1XP_016857635.1  NAD kinase isoform X4

  7. XM_011542006.1XP_011540308.1  NAD kinase isoform X2

    See identical proteins and their annotated locations for XP_011540308.1

    Conserved Domains (1) summary
    cl01255
    Location:68330
    DAGK_cat; Diacylglycerol kinase catalytic domain
  8. XM_017002145.2XP_016857634.1  NAD kinase isoform X4

  9. XM_017002144.2XP_016857633.1  NAD kinase isoform X3

RNA

  1. XR_946747.2 RNA Sequence

  2. XR_001737371.2 RNA Sequence

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