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Dhodh dihydroorotate dehydrogenase (quinone) [ Rattus norvegicus (Norway rat) ]

Gene ID: 65156, updated on 18-Sep-2024

Summary

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Official Symbol
Dhodhprovided by RGD
Official Full Name
dihydroorotate dehydrogenase (quinone)provided by RGD
Primary source
RGD:68352
See related
EnsemblRapid:ENSRNOG00000015063 AllianceGenome:RGD:68352
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables FMN binding activity; dihydroorotate dehydrogenase activity; and ubiquinone binding activity. Involved in several processes, including 'de novo' pyrimidine nucleobase biosynthetic process; lactation; and response to L-arginine. Located in mitochondrial inner membrane and neuronal cell body. Human ortholog(s) of this gene implicated in postaxial acrofacial dysostosis. Orthologous to human DHODH (dihydroorotate dehydrogenase (quinone)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 46.5), Thymus (RPKM 40.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
19q12
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (54460636..54483049, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (37551858..37573327, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (42066103..42087906)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene DEAH-box helicase 38 Neighboring gene thioredoxin-like 4B Neighboring gene haptoglobin Neighboring gene polycystin 1 like 3, transient receptor potential channel interacting Neighboring gene IST1 factor associated with ESCRT-III Neighboring gene zinc finger protein 821

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Region-specific distribution of dihydroorotate dehydrogenase in the rat central nervous system points to pyrimidine de novo synthesis in neurons. Schaefer ChM, et al. Nucleosides Nucleotides Nucleic Acids, 2010 Jun. PMID 20544541
  2. Mechanism of leflunomide-induced proliferation of mitochondria in mammalian cells. Spodnik JH, et al. Mitochondrion, 2002 Dec. PMID 16120318
  3. Protective and anti-arthritic effects of deer antler aqua-acupuncture (DAA), inhibiting dihydroorotate dehydrogenase, on phosphate ions-mediated chondrocyte apoptosis and rat collagen-induced arthritis. Kim KS, et al. Int Immunopharmacol, 2004 Jul. PMID 15182735
  4. Inhibitor binding in a class 2 dihydroorotate dehydrogenase causes variations in the membrane-associated N-terminal domain. Hansen M, et al. Protein Sci, 2004 Apr. PMID 15044733, Free PMC Article
  5. Suppression of experimental autoimmune neuritis by leflunomide. Korn T, et al. Brain, 2001 Sep. PMID 11522581

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. High levels of both DHODH activity and immunoreactivity were observed in the neocortex, hippocampus, spinal cord and choroid plexus; lower levels were seen in the cerebellum, and only marginal expression in brainstem
    Title: Region-specific distribution of dihydroorotate dehydrogenase in the rat central nervous system points to pyrimidine de novo synthesis in neurons.
  2. Dihydroorotate dehydrogenase mRNA and protein expression analysis in normal and drug-resistant cells of different species
    Title: Dihydroorotate dehydrogenase mRNA and protein expression analysis in normal and drug-resistant cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables FMN binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables dihydroorotase activity IEA
Inferred from Electronic Annotation
more info
  
enables dihydroorotase activity ISO
Inferred from Sequence Orthology
more info
  
enables dihydroorotate dehydrogenase (quinone) activity IEA
Inferred from Electronic Annotation
more info
  
enables dihydroorotate dehydrogenase (quinone) activity ISO
Inferred from Sequence Orthology
more info
  
enables dihydroorotate dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dihydroorotate dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables dihydroorotate dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables dihydroorotate dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables dihydroorotate dehydrogenase activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables quinone binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquinone binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in 'de novo' UMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in 'de novo' UMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in 'de novo' pyrimidine nucleobase biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 'de novo' pyrimidine nucleobase biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in 'de novo' pyrimidine nucleobase biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in UDP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in UDP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in female pregnancy IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in lactation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pyrimidine ribonucleotide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitochondrial fission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to L-arginine IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to caffeine IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to starvation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dihydroorotate dehydrogenase (quinone), mitochondrial
Names
DHOdehase
dihydroorotate dehydrogenase, mitochondrial
dihydroorotate oxidase
NP_001008553.1
XP_006255663.1
XP_008770751.1
XP_063134344.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008553.2 → NP_001008553.1  dihydroorotate dehydrogenase (quinone), mitochondrial precursor

    See identical proteins and their annotated locations for NP_001008553.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/Swiss-Prot
    Q63707
    UniProtKB/TrEMBL
    A0A8I6APC4
    Related
    ENSRNOP00000091052.2, ENSRNOT00000102191.2
    Conserved Domains (2) summary
    PLN02826
    Location:4 → 394
    PLN02826; dihydroorotate dehydrogenase
    cd04738
    Location:43 → 373
    DHOD_2_like; Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    54460636..54483049 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006255601.5 → XP_006255663.1  dihydroorotate dehydrogenase (quinone), mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006255663.1

    UniProtKB/Swiss-Prot
    Q63707
    UniProtKB/TrEMBL
    A0A8I6APC4
    Conserved Domains (2) summary
    PLN02826
    Location:4 → 394
    PLN02826; dihydroorotate dehydrogenase
    cd04738
    Location:43 → 373
    DHOD_2_like; Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires ...

  2. XM_063278274.1 → XP_063134344.1  dihydroorotate dehydrogenase (quinone), mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q63707
    UniProtKB/TrEMBL
    A0A8I6APC4

  3. XM_008772529.4 → XP_008770751.1  dihydroorotate dehydrogenase (quinone), mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_008770751.1

    UniProtKB/Swiss-Prot
    Q63707
    UniProtKB/TrEMBL
    A0A8I6APC4
    Conserved Domains (2) summary
    PLN02826
    Location:4 → 394
    PLN02826; dihydroorotate dehydrogenase
    cd04738
    Location:43 → 373
    DHOD_2_like; Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires ...

RNA

  1. XR_010060026.1 RNA Sequence

  2. XR_005496685.2 RNA Sequence

  3. XR_361830.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q63707.1 GenPept UniProtKB/Swiss-Prot:Q63707

Gene LinkOut

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