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Alas1 5'-aminolevulinate synthase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 65155, updated on 27-Feb-2024

Summary

Official Symbol
Alas1provided by RGD
Official Full Name
5'-aminolevulinate synthase 1provided by RGD
Primary source
RGD:68392
See related
Ensembl:ENSRNOG00000056596 AllianceGenome:RGD:68392
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ALAS; ALA-S; ALAS-H; ALAS-N
Summary
Enables 5-aminolevulinate synthase activity. Involved in several processes, including cellular response to insulin stimulus; response to herbicide; and response to nickel cation. Located in mitochondrion. Biomarker of porphyria and pulmonary hypertension. Orthologous to human ALAS1 (5'-aminolevulinate synthase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 1059.5), Adrenal (RPKM 879.8) and 9 other tissues See more
Orthologs
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Genomic context

See Alas1 in Genome Data Viewer
Location:
8q32
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_06 current mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (106876514..106889917, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (114927704..114941038, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L29 Neighboring gene twinfilin actin-binding protein 2 Neighboring gene uncharacterized LOC120094254 Neighboring gene toll-like receptor 9 Neighboring gene POC1 centriolar protein A Neighboring gene dual specificity phosphatase 7

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 5-aminolevulinate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables 5-aminolevulinate synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables 5-aminolevulinate synthase activity IEA
Inferred from Electronic Annotation
more info
 
enables 5-aminolevulinate synthase activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cellular response to insulin stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in erythrocyte development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in heme A biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in heme A biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in heme B biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in heme B biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in heme O biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in heme O biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in heme biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in hemoglobin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protoporphyrinogen IX biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in response to bile acid IEA
Inferred from Electronic Annotation
more info
 
involved_in response to bile acid ISO
Inferred from Sequence Orthology
more info
 
involved_in response to bile acid ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to cAMP IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to cobalt ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to gonadotropin IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to herbicide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to nickel cation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to nutrient levels IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to organic substance IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to platinum ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
5-aminolevulinate synthase, non-specific, mitochondrial
Names
5-aminolevulinate synthase 1
5-aminolevulinate synthase, nonspecific, mitochondrial
5-aminolevulinic acid synthase 1
aminolevulinate, delta-, synthase 1
aminolevulinic acid synthase 1
delta-ALA synthase 1
delta-ALA synthetase
delta-aminolevulinate synthase 1
NP_077810.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024484.3NP_077810.2  5-aminolevulinate synthase, non-specific, mitochondrial precursor

    See identical proteins and their annotated locations for NP_077810.2

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000200
    UniProtKB/Swiss-Prot
    P13195, Q6P782
    UniProtKB/TrEMBL
    A0A0G2K962, A6I2Q2
    Related
    ENSRNOP00000074873.2, ENSRNOT00000086232.2
    Conserved Domains (2) summary
    pfam09029
    Location:2140
    Preseq_ALAS; 5-aminolevulinate synthase presequence
    cl18945
    Location:199604
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    115755238..115768642 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)