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RTN4R reticulon 4 receptor [ Homo sapiens (human) ]

Gene ID: 65078, updated on 3-May-2020

Summary

Official Symbol
RTN4Rprovided by HGNC
Official Full Name
reticulon 4 receptorprovided by HGNC
Primary source
HGNC:HGNC:18601
See related
Ensembl:ENSG00000040608 MIM:605566
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NGR; NOGOR
Summary
This gene encodes the receptor for reticulon 4, oligodendrocyte myelin glycoprotein and myelin-associated glycoprotein. This receptor mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 7.7), spleen (RPKM 2.5) and 10 other tissues See more
Orthologs

Genomic context

See RTN4R in Genome Data Viewer
Location:
22q11.21
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (20241415..20268318, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (20228938..20255816, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372862 Neighboring gene long intergenic non-protein coding RNA 896 Neighboring gene uncharacterized LOC105372863 Neighboring gene uncharacterized LOC105372864 Neighboring gene microRNA 1286 Neighboring gene proline dehydrogenase 1 pseudogene Neighboring gene DiGeorge syndrome critical region gene 6 like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Schizophrenia
MedGen: C0036341 OMIM: 181500 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chondroitin sulfate binding ISS
Inferred from Sequence or Structural Similarity
more info
 
ganglioside GM1 binding IDA
Inferred from Direct Assay
more info
PubMed 
ganglioside GT1b binding IDA
Inferred from Direct Assay
more info
PubMed 
heparin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
neuregulin receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
signaling receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
signaling receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
axonogenesis IEA
Inferred from Electronic Annotation
more info
 
cell surface receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
corpus callosum development ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of axon extension ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of axon regeneration ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of axonogenesis TAS
Traceable Author Statement
more info
 
negative regulation of neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
neuronal signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of Rho protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
anchored component of external side of plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
axonal growth cone ISS
Inferred from Sequence or Structural Similarity
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
dendritic shaft ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
extracellular exosome HDA PubMed 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane raft ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
 
neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
perikaryon IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
presynapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
reticulon-4 receptor
Names
Nogo-66 receptor
UNQ330/PRO526
nogo receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012176.2 RefSeqGene

    Range
    4976..31879
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_023004.6NP_075380.1  reticulon-4 receptor precursor

    See identical proteins and their annotated locations for NP_075380.1

    Status: REVIEWED

    Source sequence(s)
    AC007663, AL834449, BM762412
    Consensus CDS
    CCDS13777.1
    UniProtKB/Swiss-Prot
    Q9BZR6
    Related
    ENSP00000043402.7, ENST00000043402.8
    Conserved Domains (4) summary
    sd00033
    Location:6082
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:156214
    LRR_8; Leucine rich repeat
    cl25642
    Location:332417
    DUF390; Protein of unknown function (DUF390)
    cl26793
    Location:82260
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    20241415..20268318 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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