RTN4R reticulon 4 receptor [Homo sapiens (human)] - Gene

Summary

Official Symbol: RTN4Rprovided by HGNC
Official Full Name: reticulon 4 receptorprovided by HGNC
Primary source: HGNC:HGNC:18601
See related: Ensembl:ENSG00000040608 MIM:605566; AllianceGenome:HGNC:18601
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NGR; NOGOR
Summary: This gene encodes the receptor for reticulon 4, oligodendrocyte myelin glycoprotein and myelin-associated glycoprotein. This receptor mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. [provided by RefSeq, Jul 2008]
Expression: Biased expression in brain (RPKM 7.7), spleen (RPKM 2.5) and 10 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 22q11.21

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2025_08	current	GRCh38.p14 (GCF_000001405.40)	22	NC_000022.11 (20241415..20268318, complement)
RS_2025_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	22	NC_060946.1 (20621207..20649434, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	22	NC_000022.10 (20228938..20255841, complement)

Chromosome 22 - NC_000022.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RTN4/NoGo-receptor binding to BAI adhesion-GPCRs regulates neuronal development.
Title: RTN4/NoGo-receptor binding to BAI adhesion-GPCRs regulates neuronal development.
Modulation of Nogo receptor 1 expression orchestrates myelin-associated infiltration of glioblastoma.
Title: Modulation of Nogo receptor 1 expression orchestrates myelin-associated infiltration of glioblastoma.
the treatment of glioblastoma multiforme cells with TGFb1 suppressed NgR maturation. We showed that NgR and vimentin interact, which could be a possible mechanism for the suppression of NgR maturation.
Title: Nogo receptor-vimentin interaction: a novel mechanism for the invasive activity of glioblastoma multiforme.
SATB2 and NRG1 overexpression induced many of the signaling pathways.
Title: SATB2 and NGR1: potential upstream regulatory factors in uterine leiomyomas.
Nociceptin receptor ORL1 increases the cell surface expression of reticulon 4 receptor (NgR1) in HEK293T cells.
Title: The nociceptin receptor inhibits axonal regeneration and recovery from spinal cord injury.
miR-10 can promote microglia cell proliferation and inhibit the inflammatory cytokine secretion via targeting the NgR gene to down-regulate its expression.
Title: MiR-10 targets NgR to modulate the proliferation of microglial cells and the secretion of inflammatory cytokines.
Results indicate an association between RTN4R genetic variation and phenotypes linked to prefrontal function. In an hierarchical approach, a SNP (rs696884) selected based on its association with RTN4R postmortem mRNA expression in the prefrontal cortex was shown to modulate prefrontal activity during working memory processing.
Title: Genetic variation is associated with RTN4R expression and working memory processing in healthy humans.
NgR1 ligand has a role in in oligodendrocyte progenitor cells fate in the context of a specific and common type of stroke
Title: Nogo receptor blockade overcomes remyelination failure after white matter stroke and stimulates functional recovery in aged mice.
Allelic variation of the rs701428 SNP of RTN4R was significantly associated with volumetric differences in gray matter of the lingual gyrus and cuneus of the occipital lobe. Moreover, occipital gray matter volumes were robustly associated with ultra high risk symptoms of psychosis in the presence of the G allele of rs701428.
Title: Associations between neurodevelopmental genes, neuroanatomy, and ultra high risk symptoms of psychosis in 22q11.2 deletion syndrome.
Panax notoginseng saponins provide neuroprotective effects in a rat model of cerebral ischemia and SH-SY5Y cells exposed to oxygen/glucose deprivation injury by inhibiting the overexpression of NgR1, RhoA, and ROCK2.
Title: Panax notoginseng saponins provide neuroprotection by regulating NgR1/RhoA/ROCK2 pathway expression, in vitro and in vivo.

Submit: New GeneRIF Correction See all GeneRIFs (44)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Schizophrenia MedGen: C0036341 OMIM: 181500 GeneReviews: Not available	Compare labs

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables chondroitin sulfate binding	IEA Inferred from Electronic Annotation more info
enables chondroitin sulfate binding	ISS Inferred from Sequence or Structural Similarity more info
enables ganglioside GM1 binding	IBA Inferred from Biological aspect of Ancestor more info
enables ganglioside GM1 binding	IDA Inferred from Direct Assay more info	PubMed
enables ganglioside GT1b binding	IBA Inferred from Biological aspect of Ancestor more info
enables ganglioside GT1b binding	IDA Inferred from Direct Assay more info	PubMed
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables heparin binding	ISS Inferred from Sequence or Structural Similarity more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables neuregulin receptor activity	IEA Inferred from Electronic Annotation more info
enables neuregulin receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables signaling receptor activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within axonogenesis	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in corpus callosum development	IEA Inferred from Electronic Annotation more info
involved_in corpus callosum development	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of axon extension	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of axon extension	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of axon regeneration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of axon regeneration	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuronal signal transduction	IEA Inferred from Electronic Annotation more info
involved_in neuronal signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of Rho protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of postsynapse assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of synapse assembly	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info
located_in axonal growth cone	IEA Inferred from Electronic Annotation more info
located_in axonal growth cone	ISS Inferred from Sequence or Structural Similarity more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendritic shaft	IEA Inferred from Electronic Annotation more info
located_in dendritic shaft	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in extracellular exosome	HDA more info	PubMed
is_active_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in growth cone	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in membrane raft	ISS Inferred from Sequence or Structural Similarity more info
located_in neuron projection	IEA Inferred from Electronic Annotation more info
located_in neuron projection	ISS Inferred from Sequence or Structural Similarity more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISS Inferred from Sequence or Structural Similarity more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: reticulon-4 receptor

Names: Nogo-66 receptor; UNQ330/PRO526; nogo receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012176.2 RefSeqGene

Range

4976..31879

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_023004.6 → NP_075380.1 reticulon-4 receptor precursor

See identical proteins and their annotated locations for NP_075380.1

Status: REVIEWED

Source sequence(s)

AC007663, AL834449, BM762412

Consensus CDS

CCDS13777.1

UniProtKB/Swiss-Prot

D3DX28, Q9BZR6

UniProtKB/TrEMBL

H7C0V4

Related

ENSP00000043402.7, ENST00000043402.8

Conserved Domains (4) summary

sd00033
Location:60 → 82

LRR_RI; leucine-rich repeat [structural motif]

pfam04094
Location:332 → 417

DUF390; Protein of unknown function (DUF390)

pfam13855
Location:156 → 214

LRR_8; Leucine rich repeat

cl15307
Location:260 → 296

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain