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MRPL36 mitochondrial ribosomal protein L36 [ Homo sapiens (human) ]

Gene ID: 64979, updated on 1-Jun-2020

Summary

Official Symbol
MRPL36provided by HGNC
Official Full Name
mitochondrial ribosomal protein L36provided by HGNC
Primary source
HGNC:HGNC:14490
See related
Ensembl:ENSG00000171421 MIM:611842
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RPMJ; BRIP1; L36mt; PRPL36; MRP-L36
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 2p. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 15.3), adrenal (RPKM 7.9) and 25 other tissues See more
Orthologs

Genomic context

See MRPL36 in Genome Data Viewer
Location:
5p15.33
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (1798385..1801432, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (1798499..1799956, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374614 Neighboring gene microRNA 4277 Neighboring gene uncharacterized LOC101929003 Neighboring gene NADH:ubiquinone oxidoreductase subunit S6 Neighboring gene VISTA enhancer hs2567 Neighboring gene long intergenic non-protein coding RNA 2116

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC104245

Gene Ontology Provided by GOA

Function Evidence Code Pubs
structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
mitochondrial translational elongation TAS
Traceable Author Statement
more info
 
mitochondrial translational termination TAS
Traceable Author Statement
more info
 
ribosome biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial large ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial large ribosomal subunit NAS
Non-traceable Author Statement
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 
nuclear body IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
39S ribosomal protein L36, mitochondrial
Names
BRCA1-interacting protein 1
mitochondrial large ribosomal subunit protein bL36m
putative BRCA1-interacting protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032479.4NP_115868.1  39S ribosomal protein L36, mitochondrial

    See identical proteins and their annotated locations for NP_115868.1

    Status: REVIEWED

    Source sequence(s)
    BC104652, BG185418
    Consensus CDS
    CCDS3865.1
    UniProtKB/Swiss-Prot
    Q9P0J6
    Related
    ENSP00000423152.1, ENST00000505059.7
    Conserved Domains (1) summary
    pfam00444
    Location:66103
    Ribosomal_L36; Ribosomal protein L36

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    1798385..1801432 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514080.2XP_011512382.1  39S ribosomal protein L36, mitochondrial isoform X2

    Conserved Domains (1) summary
    pfam00444
    Location:81118
    Ribosomal_L36; Ribosomal protein L36
  2. XM_017009751.2XP_016865240.1  39S ribosomal protein L36, mitochondrial isoform X3

    UniProtKB/Swiss-Prot
    Q9P0J6
    Conserved Domains (1) summary
    pfam00444
    Location:66103
    Ribosomal_L36; Ribosomal protein L36
  3. XM_017009750.1XP_016865239.1  39S ribosomal protein L36, mitochondrial isoform X3

    UniProtKB/Swiss-Prot
    Q9P0J6
    Related
    ENSP00000372093.6, ENST00000382647.7
    Conserved Domains (1) summary
    pfam00444
    Location:66103
    Ribosomal_L36; Ribosomal protein L36
  4. XM_017009752.1XP_016865241.1  39S ribosomal protein L36, mitochondrial isoform X3

    UniProtKB/Swiss-Prot
    Q9P0J6
    Related
    ENSP00000423399.1, ENST00000508987.1
    Conserved Domains (1) summary
    pfam00444
    Location:66103
    Ribosomal_L36; Ribosomal protein L36
  5. XM_011514079.2XP_011512381.1  39S ribosomal protein L36, mitochondrial isoform X1

    Conserved Domains (1) summary
    pfam00444
    Location:132169
    Ribosomal_L36; Ribosomal protein L36
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