U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cldn12 claudin 12 [ Mus musculus (house mouse) ]

Gene ID: 64945, updated on 12-Mar-2024

Summary

Official Symbol
Cldn12provided by MGI
Official Full Name
claudin 12provided by MGI
Primary source
MGI:MGI:1929288
See related
Ensembl:ENSMUSG00000046798 AllianceGenome:MGI:1929288
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene, along with several other family members, is expressed in the inner ear. The protein encoded by this gene and another family member, claudin 2, are critical for vitamin D-dependent Ca2+ absorption between enterocytes. Multiple alternatively spliced transcript variants encoding the same protein have been found. [provided by RefSeq, Oct 2011]
Expression
Ubiquitous expression in kidney adult (RPKM 18.9), liver adult (RPKM 14.7) and 27 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Location:
5 A1; 5 2.98 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (5555109..5564953, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (5505015..5514976, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene PTTG1IP family member 2 Neighboring gene STARR-seq mESC enhancer starr_12343 Neighboring gene predicted gene, 30325 Neighboring gene GTP-binding protein 10 (putative) Neighboring gene family with sequence similarity 237, member B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
NOT involved_in tight junction assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
located_in lateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in tight junction IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001193659.2NP_001180588.1  claudin-12

    See identical proteins and their annotated locations for NP_001180588.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, as compared to variant 1.
    Source sequence(s)
    AC068663
    Consensus CDS
    CCDS19074.1
    UniProtKB/Swiss-Prot
    Q3TM65, Q8BH13, Q9ET43
    Related
    ENSMUSP00000111105.2, ENSMUST00000115445.8
  2. NM_001193660.2NP_001180589.1  claudin-12

    See identical proteins and their annotated locations for NP_001180589.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, as compared to variant 1.
    Source sequence(s)
    AC068663
    Consensus CDS
    CCDS19074.1
    UniProtKB/Swiss-Prot
    Q3TM65, Q8BH13, Q9ET43
    Related
    ENSMUSP00000136988.2, ENSMUST00000179804.8
  3. NM_001193661.2NP_001180590.1  claudin-12

    See identical proteins and their annotated locations for NP_001180590.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, as compared to variant 1.
    Source sequence(s)
    AC068663
    Consensus CDS
    CCDS19074.1
    UniProtKB/Swiss-Prot
    Q3TM65, Q8BH13, Q9ET43
    Related
    ENSMUSP00000111106.2, ENSMUST00000115446.8
  4. NM_001425672.1NP_001412601.1  claudin-12

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, as compared to variant 1.
    Source sequence(s)
    AC068663
    UniProtKB/Swiss-Prot
    Q3TM65, Q8BH13, Q9ET43
  5. NM_001425673.1NP_001412602.1  claudin-12

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, as compared to variant 1.
    Source sequence(s)
    AC068663
    UniProtKB/Swiss-Prot
    Q3TM65, Q8BH13, Q9ET43
  6. NM_022890.3NP_075028.1  claudin-12

    See identical proteins and their annotated locations for NP_075028.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) and variants 2-6 encode the same protein.
    Source sequence(s)
    AC068663
    Consensus CDS
    CCDS19074.1
    UniProtKB/Swiss-Prot
    Q3TM65, Q8BH13, Q9ET43
    Related
    ENSMUSP00000061928.8, ENSMUST00000060947.14

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    5555109..5564953 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240674.1XP_011238976.1  claudin-12 isoform X1

    See identical proteins and their annotated locations for XP_011238976.1

    UniProtKB/Swiss-Prot
    Q3TM65, Q8BH13, Q9ET43
  2. XM_006503598.5XP_006503661.1  claudin-12 isoform X1

    See identical proteins and their annotated locations for XP_006503661.1

    UniProtKB/Swiss-Prot
    Q3TM65, Q8BH13, Q9ET43