Pes1 pescadillo ribosomal biogenesis factor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pes1provided by MGI
Official Full Name: pescadillo ribosomal biogenesis factor 1provided by MGI
Primary source: MGI:MGI:1890613
See related: Ensembl:ENSMUSG00000020430 AllianceGenome:MGI:1890613
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable RNA binding activity. Acts upstream of or within maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); nucleolus organization; and protein localization to organelle. Located in condensed chromosome and nucleolus. Part of PeBoW complex. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and skeletal muscle. Orthologous to human PES1 (pescadillo ribosomal biogenesis factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 25.3), placenta adult (RPKM 24.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11; 11 A1

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (3913975..3930004)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (3963975..3980004)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PES1 facilitates telomerase assembly by promoting direct interaction between TERT and TR without affecting TERT and TR levels
Title: PES1 is a critical component of telomerase assembly and regulates cellular senescence.
These data suggest that PES1 is a marker of neuroblastoma outcome, that it regulates neuroblastoma cell proliferation, and is associated with neuroblastoma differentiation.
Title: Nucleolar protein PES1 is a marker of neuroblastoma outcome and is associated with neuroblastoma differentiation.
Data show that pescadillo associates with several structures that are associated with nucleogenesis, and that loss of function results in embryonic lethality due to disrupted ribosome biosynthesis.
Title: Pescadillo is essential for nucleolar assembly, ribosome biogenesis, and mammalian cell proliferation.
Interaction with Bop1 is essential for the efficient incorporation of Pes1 into nucleolar preribosomal complexes.
Title: Physical and functional interaction between Pes1 and Bop1 in mammalian ribosome biogenesis.
Mechanisms for the ability of Pes1 to transform cells, and its failure to immortalize them.
Title: Role of pescadillo in the transformation and immortalization of mammalian cells.
Mtap1b-Light chain 1 has the potential to repress cell proliferation by modulating the nucleolar levels of Pes1
Title: Light chain 1 of microtubule-associated protein 1B can negatively regulate the action of Pes1.
effects of PES1 and UBF1 expression on the growth and differentiation of cell lines derived from 32D cells, an interleukin-3 (IL-3)-dependent murine myeloid cell line
Title: Role of pescadillo and upstream binding factor in the proliferation and differentiation of murine myeloid cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Pes1 (e-PCR), detects polymorphism
- UniSTS:205460

Homology

Homologs of the Pes1 gene: The Pes1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
Orthologs from Annotation Pipeline: 496 organisms have orthologs with human gene Pes1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	ISO Inferred from Sequence Orthology more info
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nucleolus organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein localization to organelle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within rRNA processing	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within rRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within rRNA processing	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ribosome biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of PeBoW complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of PeBoW complex	IDA Inferred from Direct Assay more info	PubMed
part_of PeBoW complex	ISO Inferred from Sequence Orthology more info
located_in chromosome	ISO Inferred from Sequence Orthology more info
located_in condensed chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of preribosome, large subunit precursor	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: pescadillo homolog

Names: pescadillo homolog 1, containing BRCT domain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022889.3 → NP_075027.1 pescadillo homolog

See identical proteins and their annotated locations for NP_075027.1

Status: PROVISIONAL

Source sequence(s)

AL807395

Consensus CDS

CCDS24372.1

UniProtKB/Swiss-Prot

Q542F0, Q9EQ61

Related

ENSMUSP00000020705.5, ENSMUST00000020705.5

Conserved Domains (3) summary

COG5163
Location:6 → 566

NOP7; Protein required for biogenesis of the 60S ribosomal subunit [Translation, ribosomal structure and biogenesis]

pfam06732
Location:9 → 278

Pescadillo_N; Pescadillo N-terminus

pfam16589
Location:327 → 413

BRCT_2; BRCT domain, a BRCA1 C-terminus domain