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Pes1 pescadillo ribosomal biogenesis factor 1 [ Mus musculus (house mouse) ]

Gene ID: 64934, updated on 5-Mar-2024

Summary

Official Symbol
Pes1provided by MGI
Official Full Name
pescadillo ribosomal biogenesis factor 1provided by MGI
Primary source
MGI:MGI:1890613
See related
Ensembl:ENSMUSG00000020430 AllianceGenome:MGI:1890613
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable RNA binding activity. Acts upstream of or within maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); nucleolus organization; and protein localization to organelle. Located in condensed chromosome and nucleolus. Part of PeBoW complex. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and skeletal muscle. Orthologous to human PES1 (pescadillo ribosomal biogenesis factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 25.3), placenta adult (RPKM 24.5) and 28 other tissues See more
Orthologs
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Genomic context

See Pes1 in Genome Data Viewer
Location:
11 A1; 11 2.79 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (3913975..3930004)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (3963975..3980004)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene transcobalamin 2 Neighboring gene STARR-seq mESC enhancer starr_28367 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene galactose-3-O-sulfotransferase 1 Neighboring gene predicted gene, 46265 Neighboring gene predicted gene 11954

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of PeBoW complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of PeBoW complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of PeBoW complex ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome ISO
Inferred from Sequence Orthology
more info
 
located_in condensed chromosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of preribosome, large subunit precursor ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
pescadillo homolog
Names
pescadillo homolog 1, containing BRCT domain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022889.3NP_075027.1  pescadillo homolog

    See identical proteins and their annotated locations for NP_075027.1

    Status: PROVISIONAL

    Source sequence(s)
    AL807395
    Consensus CDS
    CCDS24372.1
    UniProtKB/Swiss-Prot
    Q542F0, Q9EQ61
    UniProtKB/TrEMBL
    Q5SQ20
    Related
    ENSMUSP00000020705.5, ENSMUST00000020705.5
    Conserved Domains (3) summary
    COG5163
    Location:6566
    NOP7; Protein required for biogenesis of the 60S ribosomal subunit [Translation, ribosomal structure and biogenesis]
    pfam06732
    Location:9278
    Pescadillo_N; Pescadillo N-terminus
    pfam16589
    Location:327413
    BRCT_2; BRCT domain, a BRCA1 C-terminus domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    3913975..3930004
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)