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LRRC19 leucine rich repeat containing 19 [ Homo sapiens (human) ]

Gene ID: 64922, updated on 23-Nov-2021

Summary

Official Symbol
LRRC19provided by HGNC
Official Full Name
leucine rich repeat containing 19provided by HGNC
Primary source
HGNC:HGNC:23379
See related
Ensembl:ENSG00000184434 MIM:619068
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in colon (RPKM 23.4), kidney (RPKM 20.5) and 4 other tissues See more
Orthologs
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Genomic context

See LRRC19 in Genome Data Viewer
Location:
9p21.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (26993136..27005672, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (26993134..27005670, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene phospholipase A2 activating protein Neighboring gene IFT74 antisense RNA 1 Neighboring gene intraflagellar transport 74 Neighboring gene TEK receptor tyrosine kinase Neighboring gene RNA, 5S ribosomal pseudogene 280 Neighboring gene ribosomal protein L36a pseudogene 34

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Clone Names

  • FLJ21302

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in TRAF-mediated signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in host-mediated regulation of intestinal microbiota composition ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in interleukin-8 production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of NIK/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of NIK/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cytokine production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in toll-like receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
leucine-rich repeat-containing protein 19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022901.3NP_075052.1  leucine-rich repeat-containing protein 19 precursor

    See identical proteins and their annotated locations for NP_075052.1

    Status: VALIDATED

    Source sequence(s)
    AK024955, AK025070, AL355432, BC126156, BF431646
    Consensus CDS
    CCDS6518.1
    UniProtKB/Swiss-Prot
    Q9H756
    Related
    ENSP00000369395.5, ENST00000380055.6
    Conserved Domains (4) summary
    sd00031
    Location:4971
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:97157
    LRR_8; Leucine rich repeat
    pfam15176
    Location:257370
    LRR19-TM; Leucine-rich repeat family 19 TM domain
    cl15307
    Location:176227
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    26993136..27005672 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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