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NIBAN2 niban apoptosis regulator 2 [ Homo sapiens (human) ]

Gene ID: 64855, updated on 13-Mar-2020

Summary

Official Symbol
NIBAN2provided by HGNC
Official Full Name
niban apoptosis regulator 2provided by HGNC
Primary source
HGNC:HGNC:25282
See related
Ensembl:ENSG00000136830 MIM:614045
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OC58; MEG-3; C9orf88; FAM129B; MINERVA; bA356B19.6
Expression
Broad expression in esophagus (RPKM 167.0), lung (RPKM 55.7) and 20 other tissues See more
Orthologs

Genomic context

See NIBAN2 in Genome Data Viewer
Location:
9q34.11
Exon count:
17
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (127505339..127579031, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (130267618..130341268, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, H/ACA box 65 Neighboring gene ribosomal protein L12 Neighboring gene leucine rich repeat and sterile alpha motif containing 1 Neighboring gene uncharacterized LOC105376281 Neighboring gene Sharpr-MPRA regulatory region 14561 Neighboring gene FAM129B intron CAGE-defined low expression enhancer Neighboring gene Sharpr-MPRA regulatory region 10550 Neighboring gene syntaxin binding protein 1 Neighboring gene VISTA enhancer hs2342 Neighboring gene microRNA 3911

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13518, FLJ22151, FLJ22298, DKFZP434H0820

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cadherin binding HDA PubMed 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
 
cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
gonadotropin secretion IEP
Inferred from Expression Pattern
more info
PubMed 
gonadotropin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
hypomethylation of CpG island ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of DNA biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of Notch signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of vascular endothelial growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of embryonic development ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of skeletal muscle fiber development ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription regulatory region DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
NOT nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
protein Niban 2
Names
family with sequence similarity 129 member B
melanoma invasion by ERK
niban-like protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001035534.3NP_001030611.1  protein Niban 2 isoform 2

    See identical proteins and their annotated locations for NP_001030611.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and the 5' coding region compared to variant 1. It encodes isoform 2, which is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AL390116, AL445222
    Consensus CDS
    CCDS35144.1
    UniProtKB/Swiss-Prot
    Q96TA1
    UniProtKB/TrEMBL
    A0A024R872
    Related
    ENSP00000362411.3, ENST00000373314.7
    Conserved Domains (2) summary
    pfam00169
    Location:56179
    PH; PH domain
    cl17171
    Location:122175
    PH-like; Pleckstrin homology-like domain
  2. NM_022833.4NP_073744.2  protein Niban 2 isoform 1

    See identical proteins and their annotated locations for NP_073744.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL137555, BM557756, BX280720
    Consensus CDS
    CCDS35145.1
    UniProtKB/Swiss-Prot
    Q96TA1
    Related
    ENSP00000362409.3, ENST00000373312.4
    Conserved Domains (2) summary
    pfam00169
    Location:69192
    PH; PH domain
    cl17171
    Location:135188
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    127505339..127579031 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011518925.1XP_011517227.1  protein Niban 2 isoform X2

    Conserved Domains (2) summary
    pfam00169
    Location:99222
    PH; PH domain
    cl17171
    Location:165218
    PH-like; Pleckstrin homology-like domain
  2. XM_005252135.2XP_005252192.2  protein Niban 2 isoform X1

    Conserved Domains (2) summary
    pfam00169
    Location:94217
    PH; PH domain
    cl17171
    Location:160213
    PH-like; Pleckstrin homology-like domain
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