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GNPNAT1 glucosamine-phosphate N-acetyltransferase 1 [ Homo sapiens (human) ]

Gene ID: 64841, updated on 12-May-2019

Summary

Official Symbol
GNPNAT1provided by HGNC
Official Full Name
glucosamine-phosphate N-acetyltransferase 1provided by HGNC
Primary source
HGNC:HGNC:19980
See related
Ensembl:ENSG00000100522 MIM:616510
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GNA1; GNPNAT; Gpnat1
Expression
Ubiquitous expression in liver (RPKM 17.9), colon (RPKM 9.0) and 25 other tissues See more
Orthologs

Genomic context

See GNPNAT1 in Genome Data Viewer
Location:
14q22.1
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (52775193..52791668, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (53241911..53258386, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene proteasome 26S subunit, ATPase 6 Neighboring gene serine/threonine/tyrosine interacting protein Neighboring gene uncharacterized LOC105370500 Neighboring gene COP9 signalosome subunit 9 pseudogene Neighboring gene fermitin family member 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10607

Gene Ontology Provided by GOA

Function Evidence Code Pubs
glucosamine 6-phosphate N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
monosaccharide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
N-acetylglucosamine metabolic process IEA
Inferred from Electronic Annotation
more info
 
UDP-N-acetylglucosamine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
UDP-N-acetylglucosamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
UDP-N-acetylglucosamine biosynthetic process TAS
Traceable Author Statement
more info
 
cellular response to leukemia inhibitory factor IEA
Inferred from Electronic Annotation
more info
 
glucosamine metabolic process IEA
Inferred from Electronic Annotation
more info
 
liver development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum-Golgi intermediate compartment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endosome membrane IEA
Inferred from Electronic Annotation
more info
 
late endosome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
glucosamine 6-phosphate N-acetyltransferase
Names
phosphoglucosamine acetylase
phosphoglucosamine transacetylase
NP_932332.1
XP_005268069.1
XP_006720301.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198066.4NP_932332.1  glucosamine 6-phosphate N-acetyltransferase

    See identical proteins and their annotated locations for NP_932332.1

    Status: VALIDATED

    Source sequence(s)
    AK090577, AL139317, BG717628, CA435370
    Consensus CDS
    CCDS9712.1
    UniProtKB/Swiss-Prot
    Q96EK6
    UniProtKB/TrEMBL
    A0A024R649
    Related
    ENSP00000216410.3, ENST00000216410.8
    Conserved Domains (1) summary
    cl17182
    Location:36174
    NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

    Range
    52775193..52791668 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005268012.3XP_005268069.1  glucosamine 6-phosphate N-acetyltransferase isoform X1

    See identical proteins and their annotated locations for XP_005268069.1

    UniProtKB/Swiss-Prot
    Q96EK6
    UniProtKB/TrEMBL
    A0A024R649
    Related
    ENSP00000452032.1, ENST00000557604.1
    Conserved Domains (1) summary
    cl17182
    Location:36174
    NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate
  2. XM_006720238.3XP_006720301.1  glucosamine 6-phosphate N-acetyltransferase isoform X1

    See identical proteins and their annotated locations for XP_006720301.1

    UniProtKB/Swiss-Prot
    Q96EK6
    UniProtKB/TrEMBL
    A0A024R649
    Conserved Domains (1) summary
    cl17182
    Location:36174
    NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate
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