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IQCH IQ motif containing H [ Homo sapiens (human) ]

Gene ID: 64799, updated on 23-Nov-2021

Summary

Official Symbol
IQCHprovided by HGNC
Official Full Name
IQ motif containing Hprovided by HGNC
Primary source
HGNC:HGNC:25721
See related
Ensembl:ENSG00000103599 MIM:612523
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NYDSP5
Expression
Biased expression in testis (RPKM 4.7), thyroid (RPKM 1.3) and 5 other tissues See more
Orthologs
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Genomic context

See IQCH in Genome Data Viewer
Location:
15q23
Exon count:
25
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (67254786..67501804)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (67547124..67794142)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene SMAD family member 3 Neighboring gene Sharpr-MPRA regulatory region 2708 Neighboring gene alpha and gamma adaptin binding protein Neighboring gene ribosomal protein S24 pseudogene 16 Neighboring gene VISTA enhancer hs358 Neighboring gene Sharpr-MPRA regulatory region 12968 Neighboring gene IQCH antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 13361 Neighboring gene chromosome 15 open reading frame 61 Neighboring gene mitogen-activated protein kinase kinase 5 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12476, DKFZp434F2114

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 

General protein information

Preferred Names
IQ domain-containing protein H
Names
testis development protein NYD-SP5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031715.3NP_001026885.2  IQ domain-containing protein H isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC016355, AC106000, AC110292
    Consensus CDS
    CCDS32273.1
    Related
    ENSP00000336861.4, ENST00000335894.9
  2. NM_001284347.2NP_001271276.2  IQ domain-containing protein H isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks multiple exons in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC016355, AC106000, AC110292
    Consensus CDS
    CCDS61681.1
    Related
    ENSP00000444118.1, ENST00000546225.5
  3. NM_001284348.2NP_001271277.2  IQ domain-containing protein H isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains multiple differences in the coding region, compared to variant 1, including initiation of translation at an alternate start codon. The encoded isoform (4) has distinct N- and C- termini and is shorter than isoform 1.
    Source sequence(s)
    AC016355, AC106000, AC110292
    Consensus CDS
    CCDS61680.1
    Related
    ENSP00000351617.4, ENST00000358767.7
  4. NM_001284349.2NP_001271278.1  IQ domain-containing protein H isoform 5

    See identical proteins and their annotated locations for NP_001271278.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 3' UTR and contains multiple differences in the coding region, compared to variant 1. It initiates translation at a downstream in-frame start codon. The encoded isoform (5) has a shorter N-terminus, a distinct C-terminus, and is shorter than isoform 1.
    Source sequence(s)
    AC110292, BC031041, BC039463
    Consensus CDS
    CCDS76772.1
    UniProtKB/Swiss-Prot
    Q86VS3
    Related
    ENSP00000486970.1, ENST00000629425.2
    Conserved Domains (1) summary
    TIGR00805
    Location:57119
    oat; sodium-independent organic anion transporter
  5. NM_001322470.2NP_001309399.1  IQ domain-containing protein H isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC016355, AC106000, AC110292
    Conserved Domains (1) summary
    TIGR00805
    Location:57119
    oat; sodium-independent organic anion transporter
  6. NM_001322471.2NP_001309400.1  IQ domain-containing protein H isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC016355, AC106000, AC110292
  7. NM_001322472.2NP_001309401.1  IQ domain-containing protein H isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC016355, AC106000, AC110292
  8. NM_001322473.2NP_001309402.1  IQ domain-containing protein H isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC016355, AC106000, AC110292
    Conserved Domains (1) summary
    TIGR00805
    Location:57119
    oat; sodium-independent organic anion transporter
  9. NM_001322474.2NP_001309403.1  IQ domain-containing protein H isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC016355, AC106000, AC110292
    Conserved Domains (1) summary
    TIGR00805
    Location:57119
    oat; sodium-independent organic anion transporter
  10. NM_001322475.2NP_001309404.2  IQ domain-containing protein H isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC016355, AC106000, AC110292
    Conserved Domains (1) summary
    TIGR00805
    Location:57119
    oat; sodium-independent organic anion transporter
  11. NM_022784.3NP_073621.2  IQ domain-containing protein H isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks multiple 3' coding exons and contains two alternate 3' exons, resulting in a different 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC110292, BC039463
    Consensus CDS
    CCDS10223.2
    UniProtKB/Swiss-Prot
    Q86VS3
    Related
    ENSP00000427323.1, ENST00000512104.5

RNA

  1. NR_147832.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC016355, AC106000, AC110292
    Related
    ENST00000514049.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    67254786..67501804
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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