U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

AEN apoptosis enhancing nuclease [ Homo sapiens (human) ]

Gene ID: 64782, updated on 1-Oct-2022

Summary

Official Symbol
AENprovided by HGNC
Official Full Name
apoptosis enhancing nucleaseprovided by HGNC
Primary source
HGNC:HGNC:25722
See related
Ensembl:ENSG00000181026 MIM:610177; AllianceGenome:HGNC:25722
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ISG20L1; pp12744
Summary
Enables exonuclease activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator and response to ionizing radiation. Located in nuclear membrane; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in gall bladder (RPKM 5.8), thyroid (RPKM 5.8) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See AEN in Genome Data Viewer
Location:
15q26.1
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (88604683..88632281)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (86376045..86386993)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (89164571..89175512)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S11 Neighboring gene uncharacterized LOC124903547 Neighboring gene DET1 partner of COP1 E3 ubiquitin ligase Neighboring gene long intergenic non-protein coding RNA 1586 Neighboring gene Sharpr-MPRA regulatory region 1748 Neighboring gene microRNA 1179 Neighboring gene microRNA 3529 Neighboring gene microRNA 7-2 Neighboring gene interferon stimulated exonuclease gene 20 Neighboring gene uncharacterized LOC105370960 Neighboring gene aggrecan

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12484, FLJ12562

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables exonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
apoptosis-enhancing nuclease
Names
interferon stimulated exonuclease gene 20kDa-like 1
interferon-stimulated 20 kDa exonuclease-like 1
NP_073604.3
XP_005255023.1
XP_006720708.2
XP_016877978.1
XP_047288901.1
XP_047288902.1
XP_047288903.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022767.4NP_073604.3  apoptosis-enhancing nuclease

    See identical proteins and their annotated locations for NP_073604.3

    Status: VALIDATED

    Source sequence(s)
    AC013489
    Consensus CDS
    CCDS10344.1
    UniProtKB/Swiss-Prot
    Q8WTP8, Q9H9X7
    Related
    ENSP00000331944.3, ENST00000332810.4
    Conserved Domains (2) summary
    COG0847
    Location:106314
    DnaQ; DNA polymerase III, epsilon subunit or related 3'-5' exonuclease [Replication, recombination and repair]
    cl10012
    Location:111267
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    88604683..88632281
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047432947.1XP_047288903.1  apoptosis-enhancing nuclease isoform X1

    UniProtKB/Swiss-Prot
    Q9H9X7
  2. XM_017022489.2XP_016877978.1  apoptosis-enhancing nuclease isoform X1

    UniProtKB/Swiss-Prot
    Q8WTP8, Q9H9X7
    Conserved Domains (2) summary
    COG0847
    Location:106314
    DnaQ; DNA polymerase III, epsilon subunit or related 3'-5' exonuclease [Replication, recombination and repair]
    cl10012
    Location:111267
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
  3. XM_047432946.1XP_047288902.1  apoptosis-enhancing nuclease isoform X1

    UniProtKB/Swiss-Prot
    Q9H9X7
  4. XM_047432945.1XP_047288901.1  apoptosis-enhancing nuclease isoform X2

  5. XM_005254966.2XP_005255023.1  apoptosis-enhancing nuclease isoform X1

    See identical proteins and their annotated locations for XP_005255023.1

    UniProtKB/Swiss-Prot
    Q8WTP8, Q9H9X7
    Conserved Domains (2) summary
    COG0847
    Location:106314
    DnaQ; DNA polymerase III, epsilon subunit or related 3'-5' exonuclease [Replication, recombination and repair]
    cl10012
    Location:111267
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
  6. XM_006720645.4XP_006720708.2  apoptosis-enhancing nuclease isoform X2

    Conserved Domains (2) summary
    COG0847
    Location:106204
    DnaQ; DNA polymerase III, epsilon subunit or related 3'-5' exonuclease [Replication, recombination and repair]
    cl10012
    Location:111247
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    86376045..86386993
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)