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RMND5B required for meiotic nuclear division 5 homolog B [ Homo sapiens (human) ]

Gene ID: 64777, updated on 21-Dec-2019

Summary

Official Symbol
RMND5Bprovided by HGNC
Official Full Name
required for meiotic nuclear division 5 homolog Bprovided by HGNC
Primary source
HGNC:HGNC:26181
See related
Ensembl:ENSG00000145916
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GID2; GID2B
Expression
Broad expression in testis (RPKM 28.7), esophagus (RPKM 18.0) and 25 other tissues See more
Orthologs

Genomic context

See RMND5B in Genome Data Viewer
Location:
5q35.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (178130532..178150568)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (177558002..177575567)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377754 Neighboring gene NEDD4 binding protein 3 Neighboring gene NHP2 ribonucleoprotein Neighboring gene NAD(P)HX epimerase pseudogene Neighboring gene germ cell-less 2, spermatogenesis associated

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22318, DKFZp434K0926

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
GID complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein transferase RMND5B
Names
GID complex subunit 2 homolog B
protein RMD5 homolog B
NP_001275723.1
NP_001275724.1
NP_073599.2
XP_005266026.1
XP_005266028.1
XP_005266029.1
XP_016865217.1
XP_024301936.1
XP_024301937.1
XP_024301938.1
XP_024301939.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001288794.1NP_001275723.1  E3 ubiquitin-protein transferase RMND5B isoform a

    See identical proteins and their annotated locations for NP_001275723.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AK093481, AK125337, CA440193, DB053605
    Consensus CDS
    CCDS4431.1
    UniProtKB/Swiss-Prot
    Q96G75
    UniProtKB/TrEMBL
    B3KSG5
    Related
    ENSP00000420875.1, ENST00000515098.5
    Conserved Domains (5) summary
    smart00667
    Location:116148
    LisH; Lissencephaly type-1-like homology motif
    smart00668
    Location:156212
    CTLH; C-terminal to LisH motif
    smart00757
    Location:211304
    CRA; CT11-RanBPM
    pfam10607
    Location:155299
    CLTH; CTLH/CRA C-terminal to LisH motif domain
    pfam13445
    Location:338377
    zf-RING_UBOX; RING-type zinc-finger
  2. NM_001288795.1NP_001275724.1  E3 ubiquitin-protein transferase RMND5B isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, and uses an alternate start codon, compared to variant 1. The encoded isoform (b) has a shorter and distinct N-terminus, compared to variant 1.
    Source sequence(s)
    AK093481, AK125337, BC009911, CA440193, DB053605
    Consensus CDS
    CCDS75382.1
    UniProtKB/Swiss-Prot
    Q96G75
    UniProtKB/TrEMBL
    B3KSG5, F5H6G4
    Related
    ENSP00000437630.1, ENST00000542098.2
    Conserved Domains (5) summary
    smart00667
    Location:103135
    LisH; Lissencephaly type-1-like homology motif
    smart00668
    Location:143199
    CTLH; C-terminal to LisH motif
    smart00757
    Location:198291
    CRA; CT11-RanBPM
    pfam10607
    Location:142286
    CLTH; CTLH/CRA C-terminal to LisH motif domain
    pfam13445
    Location:325364
    zf-RING_UBOX; RING-type zinc-finger
  3. NM_022762.5NP_073599.2  E3 ubiquitin-protein transferase RMND5B isoform a

    See identical proteins and their annotated locations for NP_073599.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC136632, BC009911, CA440193, DB053605
    Consensus CDS
    CCDS4431.1
    UniProtKB/Swiss-Prot
    Q96G75
    Related
    ENSP00000320623.4, ENST00000313386.9
    Conserved Domains (5) summary
    smart00667
    Location:116148
    LisH; Lissencephaly type-1-like homology motif
    smart00668
    Location:156212
    CTLH; C-terminal to LisH motif
    smart00757
    Location:211304
    CRA; CT11-RanBPM
    pfam10607
    Location:155299
    CLTH; CTLH/CRA C-terminal to LisH motif domain
    pfam13445
    Location:338377
    zf-RING_UBOX; RING-type zinc-finger

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    178130532..178150568
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446169.1XP_024301937.1  E3 ubiquitin-protein transferase RMND5B isoform X1

    Conserved Domains (3) summary
    smart00667
    Location:157189
    LisH; Lissencephaly type-1-like homology motif
    pfam10607
    Location:196340
    CLTH; CTLH/CRA C-terminal to LisH motif domain
    cd16795
    Location:377423
    dRING_RMD5B; Degenerated RING finger found in protein RMD5 homolog B (RMD5B)
  2. XM_024446171.1XP_024301939.1  E3 ubiquitin-protein transferase RMND5B isoform X3

    Conserved Domains (3) summary
    smart00667
    Location:97129
    LisH; Lissencephaly type-1-like homology motif
    pfam10607
    Location:136280
    CLTH; CTLH/CRA C-terminal to LisH motif domain
    cd16795
    Location:317363
    dRING_RMD5B; Degenerated RING finger found in protein RMD5 homolog B (RMD5B)
  3. XM_005265971.4XP_005266028.1  E3 ubiquitin-protein transferase RMND5B isoform X4

    See identical proteins and their annotated locations for XP_005266028.1

    UniProtKB/Swiss-Prot
    Q96G75
    Conserved Domains (5) summary
    smart00667
    Location:5688
    LisH; Lissencephaly type-1-like homology motif
    smart00668
    Location:96152
    CTLH; C-terminal to LisH motif
    smart00757
    Location:151244
    CRA; CT11-RanBPM
    pfam10607
    Location:95239
    CLTH; CTLH/CRA C-terminal to LisH motif domain
    pfam13445
    Location:278317
    zf-RING_UBOX; RING-type zinc-finger
  4. XM_017009728.1XP_016865217.1  E3 ubiquitin-protein transferase RMND5B isoform X4

    UniProtKB/Swiss-Prot
    Q96G75
    Conserved Domains (5) summary
    smart00667
    Location:5688
    LisH; Lissencephaly type-1-like homology motif
    smart00668
    Location:96152
    CTLH; C-terminal to LisH motif
    smart00757
    Location:151244
    CRA; CT11-RanBPM
    pfam10607
    Location:95239
    CLTH; CTLH/CRA C-terminal to LisH motif domain
    pfam13445
    Location:278317
    zf-RING_UBOX; RING-type zinc-finger
  5. XM_024446168.1XP_024301936.1  E3 ubiquitin-protein transferase RMND5B isoform X1

    Conserved Domains (3) summary
    smart00667
    Location:157189
    LisH; Lissencephaly type-1-like homology motif
    pfam10607
    Location:196340
    CLTH; CTLH/CRA C-terminal to LisH motif domain
    cd16795
    Location:377423
    dRING_RMD5B; Degenerated RING finger found in protein RMD5 homolog B (RMD5B)
  6. XM_024446170.1XP_024301938.1  E3 ubiquitin-protein transferase RMND5B isoform X1

    Conserved Domains (3) summary
    smart00667
    Location:157189
    LisH; Lissencephaly type-1-like homology motif
    pfam10607
    Location:196340
    CLTH; CTLH/CRA C-terminal to LisH motif domain
    cd16795
    Location:377423
    dRING_RMD5B; Degenerated RING finger found in protein RMD5 homolog B (RMD5B)
  7. XM_005265969.4XP_005266026.1  E3 ubiquitin-protein transferase RMND5B isoform X2

    See identical proteins and their annotated locations for XP_005266026.1

    UniProtKB/Swiss-Prot
    Q96G75
    Conserved Domains (5) summary
    smart00667
    Location:116148
    LisH; Lissencephaly type-1-like homology motif
    smart00668
    Location:156212
    CTLH; C-terminal to LisH motif
    smart00757
    Location:211304
    CRA; CT11-RanBPM
    pfam10607
    Location:155299
    CLTH; CTLH/CRA C-terminal to LisH motif domain
    pfam13445
    Location:338377
    zf-RING_UBOX; RING-type zinc-finger
  8. XM_005265972.3XP_005266029.1  E3 ubiquitin-protein transferase RMND5B isoform X4

    See identical proteins and their annotated locations for XP_005266029.1

    UniProtKB/Swiss-Prot
    Q96G75
    Conserved Domains (5) summary
    smart00667
    Location:5688
    LisH; Lissencephaly type-1-like homology motif
    smart00668
    Location:96152
    CTLH; C-terminal to LisH motif
    smart00757
    Location:151244
    CRA; CT11-RanBPM
    pfam10607
    Location:95239
    CLTH; CTLH/CRA C-terminal to LisH motif domain
    pfam13445
    Location:278317
    zf-RING_UBOX; RING-type zinc-finger
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