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ENGASE endo-beta-N-acetylglucosaminidase [ Homo sapiens (human) ]

Gene ID: 64772, updated on 5-Aug-2018

Summary

Official Symbol
ENGASEprovided by HGNC
Official Full Name
endo-beta-N-acetylglucosaminidaseprovided by HGNC
Primary source
HGNC:HGNC:24622
See related
Ensembl:ENSG00000167280 MIM:611898; Vega:OTTHUMG00000167714
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a cytosolic enzyme which catalyzes the hydrolysis of peptides and proteins with mannose modifications to produce free oligosaccharides. [provided by RefSeq, Feb 2012]
Expression
Ubiquitous expression in spleen (RPKM 23.3), duodenum (RPKM 12.9) and 24 other tissues See more
Orthologs

Genomic context

See ENGASE in Genome Data Viewer
Location:
17q25.3
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (79074812..79088603)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (77067565..77084685)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene C1QTNF1 antisense RNA 1 Neighboring gene calcium activated nucleotidase 1 Neighboring gene C1q and TNF related 1 Neighboring gene RNA binding fox-1 homolog 3 Neighboring gene microRNA 4739

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21865, DKFZp434P174

Gene Ontology Provided by GOA

Function Evidence Code Pubs
mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
protein deglycosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein deglycosylation IEA
Inferred from Electronic Annotation
more info
 
protein folding TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
cytosolic endo-beta-N-acetylglucosaminidase
Names
Di-N-acetylchitobiosyl beta-N-acetylglucosaminidase
Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
NP_001036038.1
XP_006722080.1
XP_006722081.1
XP_006722082.1
XP_016880450.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042573.2NP_001036038.1  cytosolic endo-beta-N-acetylglucosaminidase

    See identical proteins and their annotated locations for NP_001036038.1

    Status: VALIDATED

    Source sequence(s)
    AC073624, AF512564, AK025518
    Consensus CDS
    CCDS42394.1
    UniProtKB/Swiss-Prot
    Q8NFI3
    Related
    ENSP00000462333.1, OTTHUMP00000236598, ENST00000579016.5, OTTHUMT00000395807
    Conserved Domains (1) summary
    cd06547
    Location:126444
    GH85_ENGase; Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with the ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    79074812..79088603
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006722019.3XP_006722082.1  cytosolic endo-beta-N-acetylglucosaminidase isoform X4

    Conserved Domains (1) summary
    cd06547
    Location:126382
    GH85_ENGase; Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with the ...
  2. XM_017024961.1XP_016880450.1  cytosolic endo-beta-N-acetylglucosaminidase isoform X1

    Conserved Domains (1) summary
    cd06547
    Location:1314
    GH85_ENGase; Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with the ...
  3. XM_006722017.3XP_006722080.1  cytosolic endo-beta-N-acetylglucosaminidase isoform X2

    Conserved Domains (1) summary
    cd06547
    Location:3258
    GH85_ENGase; Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with the ...
  4. XM_006722018.3XP_006722081.1  cytosolic endo-beta-N-acetylglucosaminidase isoform X3

    Conserved Domains (1) summary
    cl10447
    Location:44150
    GH18_chitinase-like; The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have ...

RNA

  1. XR_001752594.1 RNA Sequence

    Related
    ENST00000300682.14, OTTHUMT00000395808
  2. XR_429920.1 RNA Sequence

  3. XR_934534.1 RNA Sequence

  4. XR_429918.1 RNA Sequence

  5. XR_429919.1 RNA Sequence

  6. XR_934535.1 RNA Sequence

  7. XR_934536.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_022759.1: Suppressed sequence

    Description
    NM_022759.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
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