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ENGASE endo-beta-N-acetylglucosaminidase [ Homo sapiens (human) ]

Gene ID: 64772, updated on 1-Mar-2024

Summary

Official Symbol
ENGASEprovided by HGNC
Official Full Name
endo-beta-N-acetylglucosaminidaseprovided by HGNC
Primary source
HGNC:HGNC:24622
See related
Ensembl:ENSG00000167280 MIM:611898; AllianceGenome:HGNC:24622
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a cytosolic enzyme which catalyzes the hydrolysis of peptides and proteins with mannose modifications to produce free oligosaccharides. [provided by RefSeq, Feb 2012]
Expression
Ubiquitous expression in spleen (RPKM 23.3), duodenum (RPKM 12.9) and 24 other tissues See more
Orthologs
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Genomic context

See ENGASE in Genome Data Viewer
Location:
17q25.3
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (79074824..79088599)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (79969760..79983540)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (77070906..77084681)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9077 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12915 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9078 Neighboring gene C1QTNF1 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:77040047-77040547 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:77042736-77043935 Neighboring gene calcium activated nucleotidase 1 Neighboring gene Sharpr-MPRA regulatory region 5335 Neighboring gene C1q and TNF related 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9079 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:77094193-77094906 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:77099175-77100160 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:77112846-77113750 Neighboring gene RNA binding fox-1 homolog 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:77157651-77158151 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:77173286-77173965 Neighboring gene uncharacterized LOC124904069 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:77179359-77180239 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9080 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:77188893-77189550 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:77198565-77199383 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:77207229-77207739 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:77219238-77219738 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:77219739-77220239 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:77223705-77224476 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12916 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:77362366-77362866 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:77369816-77369979 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:77397348-77397522 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:77400039-77400540 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:77403781-77404282 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:77404283-77404782 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:77409324-77409841 Neighboring gene Sharpr-MPRA regulatory region 4769 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:77505025-77505682 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:77528471-77529242 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:77529243-77530014 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:77544533-77545032 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:77645285-77645791 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:77655553-77656543 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:77657995-77658740 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:77665156-77666000 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47566 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:77669291-77669891 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12917 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:77673338-77673922 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:77675499-77676019 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:77680917-77681538 Neighboring gene microRNA 4739

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
cytosolic endo-beta-N-acetylglucosaminidase
Names
Di-N-acetylchitobiosyl beta-N-acetylglucosaminidase
Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
NP_001036038.1
NP_001382981.1
NP_001382982.1
NP_001382983.1
NP_001382984.1
XP_006722081.1
XP_006722082.1
XP_047292504.1
XP_047292506.1
XP_047292507.1
XP_054172918.1
XP_054172919.1
XP_054172920.1
XP_054172921.1
XP_054172922.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042573.3NP_001036038.1  cytosolic endo-beta-N-acetylglucosaminidase isoform 4

    See identical proteins and their annotated locations for NP_001036038.1

    Status: VALIDATED

    Source sequence(s)
    AC073624, AF512564, AK025518, HY070811
    Consensus CDS
    CCDS42394.1
    UniProtKB/Swiss-Prot
    Q659F0, Q8NFI3, Q8TB86, Q9H6U4
    Related
    ENSP00000462333.1, ENST00000579016.6
    Conserved Domains (1) summary
    cd06547
    Location:126444
    GH85_ENGase; Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with the ...
  2. NM_001396052.1NP_001382981.1  cytosolic endo-beta-N-acetylglucosaminidase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC073624
    Conserved Domains (1) summary
    cd06547
    Location:126444
    GH85_ENGase; Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with the ...
  3. NM_001396053.1NP_001382982.1  cytosolic endo-beta-N-acetylglucosaminidase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC073624
    Conserved Domains (1) summary
    cd06547
    Location:126444
    GH85_ENGase; Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with the ...
  4. NM_001396054.1NP_001382983.1  cytosolic endo-beta-N-acetylglucosaminidase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC073624
    Conserved Domains (1) summary
    cd06547
    Location:126507
    GH85_ENGase; Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with the ...
  5. NM_001396055.1NP_001382984.1  cytosolic endo-beta-N-acetylglucosaminidase isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC073624
    Conserved Domains (1) summary
    cd06547
    Location:126444
    GH85_ENGase; Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with the ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    79074824..79088599
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047436548.1XP_047292504.1  cytosolic endo-beta-N-acetylglucosaminidase isoform X1

  2. XM_047436551.1XP_047292507.1  cytosolic endo-beta-N-acetylglucosaminidase isoform X3

  3. XM_006722019.4XP_006722082.1  cytosolic endo-beta-N-acetylglucosaminidase isoform X5

    Conserved Domains (1) summary
    cd06547
    Location:126382
    GH85_ENGase; Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with the ...
  4. XM_047436550.1XP_047292506.1  cytosolic endo-beta-N-acetylglucosaminidase isoform X2

  5. XM_006722018.4XP_006722081.1  cytosolic endo-beta-N-acetylglucosaminidase isoform X4

    Conserved Domains (1) summary
    cl10447
    Location:44150
    GH18_chitinase-like; The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have ...

RNA

  1. XR_007065427.1 RNA Sequence

  2. XR_007065426.1 RNA Sequence

  3. XR_007065428.1 RNA Sequence

  4. XR_007065430.1 RNA Sequence

  5. XR_007065429.1 RNA Sequence

  6. XR_934534.2 RNA Sequence

  7. XR_429918.2 RNA Sequence

  8. XR_429919.2 RNA Sequence

  9. XR_934535.2 RNA Sequence

  10. XR_934536.2 RNA Sequence

  11. XR_007065431.1 RNA Sequence

    Related
    ENST00000300682.14
  12. XR_007065432.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    79969760..79983540
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054316943.1XP_054172918.1  cytosolic endo-beta-N-acetylglucosaminidase isoform X1

  2. XM_054316945.1XP_054172920.1  cytosolic endo-beta-N-acetylglucosaminidase isoform X3

  3. XM_054316947.1XP_054172922.1  cytosolic endo-beta-N-acetylglucosaminidase isoform X5

  4. XM_054316944.1XP_054172919.1  cytosolic endo-beta-N-acetylglucosaminidase isoform X2

  5. XM_054316946.1XP_054172921.1  cytosolic endo-beta-N-acetylglucosaminidase isoform X4

RNA

  1. XR_008484919.1 RNA Sequence

  2. XR_008484918.1 RNA Sequence

  3. XR_008484920.1 RNA Sequence

  4. XR_008484922.1 RNA Sequence

  5. XR_008484921.1 RNA Sequence

  6. XR_008484924.1 RNA Sequence

  7. XR_008484923.1 RNA Sequence

  8. XR_008484925.1 RNA Sequence

  9. XR_008484927.1 RNA Sequence

  10. XR_008484926.1 RNA Sequence

  11. XR_008484928.1 RNA Sequence

  12. XR_008484929.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_022759.1: Suppressed sequence

    Description
    NM_022759.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.