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CCDC14 coiled-coil domain containing 14 [ Homo sapiens (human) ]

Gene ID: 64770, updated on 22-Aug-2021

Summary

Official Symbol
CCDC14provided by HGNC
Official Full Name
coiled-coil domain containing 14provided by HGNC
Primary source
HGNC:HGNC:25766
See related
Ensembl:ENSG00000175455 MIM:617147
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in testis (RPKM 10.7), bone marrow (RPKM 8.7) and 25 other tissues See more
Orthologs
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Genomic context

See CCDC14 in Genome Data Viewer
Location:
3q21.1
Exon count:
16
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (123887383..123961412, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (123632269..123680076, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369194 Neighboring gene myosin light chain kinase Neighboring gene Sharpr-MPRA regulatory region 10510 Neighboring gene rhophilin associated tail protein 1 Neighboring gene kalirin RhoGEF kinase Neighboring gene microRNA 5002

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12892, FLJ41065, DKFZp434L1050

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in centriolar satellite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in centriolar satellite IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
coiled-coil domain-containing protein 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308317.2NP_001295246.1  coiled-coil domain-containing protein 14 isoform 2

    See identical proteins and their annotated locations for NP_001295246.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a 5' exon and contains an alternate 5' exon, compared to variant 1. This variant represents translation initiation at a downstream AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG to encode an isoform (2) that has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC117381, AL122079, BC040285
    Consensus CDS
    CCDS77806.1
    UniProtKB/Swiss-Prot
    Q49A88
    Conserved Domains (1) summary
    pfam15254
    Location:1753
    CCDC14; Coiled-coil domain-containing protein 14
  2. NM_001366335.1NP_001353264.1  coiled-coil domain-containing protein 14 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC117381
    Related
    ENSP00000386866.4, ENST00000409697.8
    Conserved Domains (1) summary
    pfam15254
    Location:49905
    CCDC14; Coiled-coil domain-containing protein 14
  3. NM_001366336.1NP_001353265.1  coiled-coil domain-containing protein 14 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC117381
    Conserved Domains (1) summary
    pfam15254
    Location:1753
    CCDC14; Coiled-coil domain-containing protein 14
  4. NM_001366337.1NP_001353266.1  coiled-coil domain-containing protein 14 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC117381
    Conserved Domains (1) summary
    pfam15254
    Location:1753
    CCDC14; Coiled-coil domain-containing protein 14
  5. NM_001366338.1NP_001353267.1  coiled-coil domain-containing protein 14 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC117381
    Conserved Domains (1) summary
    pfam15254
    Location:1610
    CCDC14; Coiled-coil domain-containing protein 14
  6. NM_001366339.1NP_001353268.1  coiled-coil domain-containing protein 14 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC117381
    Conserved Domains (1) summary
    pfam15254
    Location:5792
    CCDC14; Coiled-coil domain-containing protein 14
  7. NM_022757.5NP_073594.5  coiled-coil domain-containing protein 14 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AA743688, AI435151, AK307847, BG621278, BP382977, CN424790, DA031063, DB037501, DB306263
    Consensus CDS
    CCDS3025.2
    Related
    ENSP00000420180.3, ENST00000488653.6
    Conserved Domains (1) summary
    pfam15254
    Location:49864
    CCDC14; Coiled-coil domain-containing protein 14

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    123887383..123961412 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513081.2XP_011511383.1  coiled-coil domain-containing protein 14 isoform X8

    Conserved Domains (1) summary
    pfam15254
    Location:97667
    CCDC14; Coiled-coil domain-containing protein 14
  2. XM_005247715.4XP_005247772.1  coiled-coil domain-containing protein 14 isoform X7

    Conserved Domains (1) summary
    pfam15254
    Location:97667
    CCDC14; Coiled-coil domain-containing protein 14
  3. XM_017007061.1XP_016862550.1  coiled-coil domain-containing protein 14 isoform X13

  4. XM_006713733.3XP_006713796.1  coiled-coil domain-containing protein 14 isoform X9

    Conserved Domains (1) summary
    pfam15254
    Location:97651
    CCDC14; Coiled-coil domain-containing protein 14
  5. XM_006713731.3XP_006713794.1  coiled-coil domain-containing protein 14 isoform X2

    Conserved Domains (1) summary
    pfam15254
    Location:97810
    CCDC14; Coiled-coil domain-containing protein 14
  6. XM_005247711.4XP_005247768.1  coiled-coil domain-containing protein 14 isoform X3

    UniProtKB/Swiss-Prot
    Q49A88
    Conserved Domains (1) summary
    pfam15254
    Location:97794
    CCDC14; Coiled-coil domain-containing protein 14
  7. XM_005247713.2XP_005247770.1  coiled-coil domain-containing protein 14 isoform X6

    See identical proteins and their annotated locations for XP_005247770.1

    UniProtKB/Swiss-Prot
    Q49A88
    Related
    ENSP00000418403.1, ENST00000489746.5
    Conserved Domains (1) summary
    pfam15254
    Location:1753
    CCDC14; Coiled-coil domain-containing protein 14
  8. XM_017007059.2XP_016862548.1  coiled-coil domain-containing protein 14 isoform X10

    UniProtKB/Swiss-Prot
    Q49A88
    Conserved Domains (1) summary
    pfam15254
    Location:1594
    CCDC14; Coiled-coil domain-containing protein 14
  9. XM_024453715.1XP_024309483.1  coiled-coil domain-containing protein 14 isoform X4

    Conserved Domains (1) summary
    pfam15254
    Location:4793
    CCDC14; Coiled-coil domain-containing protein 14
  10. XM_005247716.4XP_005247773.1  coiled-coil domain-containing protein 14 isoform X12

    See identical proteins and their annotated locations for XP_005247773.1

    Conserved Domains (1) summary
    pfam15254
    Location:97523
    CCDC14; Coiled-coil domain-containing protein 14

RNA

  1. XR_001740237.1 RNA Sequence

    Related
    ENST00000409657.5
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