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Scube1 signal peptide, CUB domain, EGF-like 1 [ Mus musculus (house mouse) ]

Gene ID: 64706, updated on 8-Feb-2024

Summary

Official Symbol
Scube1provided by MGI
Official Full Name
signal peptide, CUB domain, EGF-like 1provided by MGI
Primary source
MGI:MGI:1890616
See related
Ensembl:ENSMUSG00000016763 AllianceGenome:MGI:1890616
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
7330410C13Rik; A630023E24Rik
Summary
Predicted to enable identical protein binding activity. Acts upstream of or within positive regulation of smoothened signaling pathway. Predicted to be located in external side of plasma membrane. Predicted to be active in cell surface and extracellular space. Is expressed in several structures, including allantois; embryo ectoderm; embryo mesenchyme; forelimb bud; and genitourinary system. Orthologous to human SCUBE1 (signal peptide, CUB domain and EGF like domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in subcutaneous fat pad adult (RPKM 12.6), CNS E11.5 (RPKM 8.9) and 19 other tissues See more
Orthologs
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Genomic context

See Scube1 in Genome Data Viewer
Location:
15 E1; 15 39.4 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (83486784..83609252, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (83602583..83725051, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8602 Neighboring gene translocator protein Neighboring gene tubulin tyrosine ligase-like family, member 12 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:83433173-83433433 Neighboring gene predicted gene, 52182 Neighboring gene VISTA enhancer mm84 Neighboring gene Scube1 Hedgehog-responsive enhancer Neighboring gene STARR-seq mESC enhancer starr_39342 Neighboring gene predicted gene, 52183 Neighboring gene predicted gene, 33324 Neighboring gene metallophosphoesterase domain containing 1 Neighboring gene predicted gene, 52172

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of smoothened signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
signal peptide, CUB and EGF-like domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271472.1NP_001258401.1  signal peptide, CUB and EGF-like domain-containing protein 1 isoform a precursor

    See identical proteins and their annotated locations for NP_001258401.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AK041590, AL583887, BC066066, CJ104466
    Consensus CDS
    CCDS70655.1
    UniProtKB/Swiss-Prot
    Q6NZL8, Q8C9Q4, Q9EQC6
    UniProtKB/TrEMBL
    A2A442
    Related
    ENSMUSP00000016907.8, ENSMUST00000016907.8
    Conserved Domains (5) summary
    cd00041
    Location:828939
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam07699
    Location:776823
    GCC2_GCC3; GCC2 and GCC3
    pfam12947
    Location:3772
    EGF_3; EGF domain
    pfam14670
    Location:275310
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:348384
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
  2. NM_001271473.1NP_001258402.1  signal peptide, CUB and EGF-like domain-containing protein 1 isoform c precursor

    See identical proteins and their annotated locations for NP_001258402.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks three alternate in-frame exons, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AL583887, BC080278, CJ104466
    Consensus CDS
    CCDS70654.1
    UniProtKB/TrEMBL
    A2A442, Q68EF9
    Related
    ENSMUSP00000044835.6, ENSMUST00000043634.12
    Conserved Domains (5) summary
    cd00041
    Location:717828
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam07699
    Location:665712
    GCC2_GCC3; GCC2 and GCC3
    pfam12947
    Location:3772
    EGF_3; EGF domain
    pfam14670
    Location:164199
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:237273
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
  3. NM_022723.3NP_073560.2  signal peptide, CUB and EGF-like domain-containing protein 1 isoform b precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AK041590, AL583887, BC080278, CJ104466
    Consensus CDS
    CCDS49684.1
    UniProtKB/TrEMBL
    A2A442
    Related
    ENSMUSP00000130131.2, ENSMUST00000171496.9
    Conserved Domains (5) summary
    cd00041
    Location:798909
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam07699
    Location:746793
    GCC2_GCC3; GCC2 and GCC3
    pfam12947
    Location:3772
    EGF_3; EGF domain
    pfam14670
    Location:245280
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:318354
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    83486784..83609252 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521242.5XP_006521305.1  signal peptide, CUB and EGF-like domain-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    A2A442
    Conserved Domains (5) summary
    cd00041
    Location:867978
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam07699
    Location:815862
    Ephrin_rec_like; Putative ephrin-receptor like
    pfam12947
    Location:76111
    EGF_3; EGF domain
    pfam14670
    Location:314349
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:387423
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
  2. XM_017316719.2XP_017172208.1  signal peptide, CUB and EGF-like domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A2A442
    Conserved Domains (5) summary
    cd00041
    Location:867978
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam07699
    Location:815862
    Ephrin_rec_like; Putative ephrin-receptor like
    pfam12947
    Location:76111
    EGF_3; EGF domain
    pfam14670
    Location:314349
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:387423
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
  3. XM_036159534.1XP_036015427.1  signal peptide, CUB and EGF-like domain-containing protein 1 isoform X3

    Conserved Domains (3) summary
    pfam12947
    Location:76111
    EGF_3; EGF domain
    pfam14670
    Location:314349
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:387423
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...