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Htra2 HtrA serine peptidase 2 [ Mus musculus (house mouse) ]

Gene ID: 64704, updated on 22-Jan-2023

Summary

Official Symbol
Htra2provided by MGI
Official Full Name
HtrA serine peptidase 2provided by MGI
Primary source
MGI:MGI:1928676
See related
Ensembl:ENSMUSG00000068329 AllianceGenome:MGI:1928676
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Omi; mnd2; Prss25
Summary
Enables peptidase activity. Involved in several processes, including cellular response to oxidative stress; negative regulation of mitophagy in response to mitochondrial depolarization; and positive regulation of apoptotic process. Acts upstream of or within several processes, including adult walking behavior; intrinsic apoptotic signaling pathway; and nervous system development. Located in cytoplasmic side of plasma membrane and mitochondrion. Part of CD40 receptor complex. Is expressed in several structures, including gut; nervous system; reproductive system; thymus; and trachea. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria type 8; Parkinson's disease; and motor neuron disease. Orthologous to human HTRA2 (HtrA serine peptidase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14.5 (RPKM 40.6), liver E14 (RPKM 36.8) and 28 other tissues See more
Orthologs
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Genomic context

See Htra2 in Genome Data Viewer
Location:
6 C3; 6 35.94 cM
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (83028247..83031552, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (83051266..83054571, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene docking protein 1 Neighboring gene lysyl oxidase-like 3 Neighboring gene microRNA 7040 Neighboring gene ancient ubiquitous protein 1 Neighboring gene DEAQ RNA-dependent ATPase Neighboring gene T cell leukemia, homeobox 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: Loxl3

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables serine-type peptidase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within adult locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within adult walking behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to heat ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to interferon-beta ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to retinoic acid ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within forebrain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of mitophagy in response to mitochondrial depolarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitochondrion organization ISO
Inferred from Sequence Orthology
more info
 
involved_in programmed cell death IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in programmed cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in proteolysis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of CD40 receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial intermembrane space ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of serine-type endopeptidase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
serine protease HTRA2, mitochondrial
Names
high temperature requirement protein A2
motor neuron degeneration 2
omi stress-regulated endoprotease
protease, serine, 25
serine protease 25
serine protease OMI
serine proteinase OMI
NP_062726.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019752.3NP_062726.3  serine protease HTRA2, mitochondrial

    See identical proteins and their annotated locations for NP_062726.3

    Status: VALIDATED

    Source sequence(s)
    AC104324, AF175324, BM899329
    Consensus CDS
    CCDS20267.1
    UniProtKB/Swiss-Prot
    Q9JIY5, Q9R108
    Related
    ENSMUSP00000087073.7, ENSMUST00000089645.13
    Conserved Domains (3) summary
    COG0265
    Location:125454
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00987
    Location:360452
    PDZ_serine_protease; PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind ...
    pfam13365
    Location:182320
    Trypsin_2; Trypsin-like peptidase domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    83028247..83031552 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)