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ADORA2A-AS1 ADORA2A antisense RNA 1 [ Homo sapiens (human) ]

Gene ID: 646023, updated on 23-Nov-2021

Summary

Official Symbol
ADORA2A-AS1provided by HGNC
Official Full Name
ADORA2A antisense RNA 1provided by HGNC
Primary source
HGNC:HGNC:37122
See related
Ensembl:ENSG00000178803
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C22orf45
Annotation information
Note: This locus has been reported as a novel protein-coding gene (Knowled and McLysaght, PMID: 19726446). NCBI has noted that there is uncertainty about the correct definition of the full-length transcript and which of the predicted short open reading frames is translated. Therefore, we have elected to represent the locus as non-coding until additional data supporting a specific protein product becomes available. [13 Feb 2013]
Expression
Biased expression in testis (RPKM 3.7), kidney (RPKM 2.7) and 10 other tissues See more
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Genomic context

See ADORA2A-AS1 in Genome Data Viewer
Location:
22q11.23
Exon count:
11
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (24429206..24495074, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (24825174..24891042, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene SPECC1L-ADORA2A readthrough (NMD candidate) Neighboring gene ribosomal protein S10 pseudogene 29 Neighboring gene sperm antigen with calponin homology and coiled-coil domains 1 like Neighboring gene uncharacterized LOC105372960 Neighboring gene adenosine A2a receptor Neighboring gene beta-ureidopropionase 1 Neighboring gene guanylyl cyclase domain containing 1 Neighboring gene small nuclear ribonucleoprotein D3 polypeptide Neighboring gene leucine rich repeat containing 75B Neighboring gene gamma-glutamyltransferase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
EBI GWAS Catalog

General gene information

Markers

Clone Names

  • FLJ34651

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_028483.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) is shorter and differs at the 3' end compared to variant 1. The protein coding capacity of this transcript is unknown.
    Source sequence(s)
    BC045098, DA917327, DB449907
    Related
    ENST00000427813.6
  2. NR_028484.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. The protein-coding potential of this transcript is unknown.
    Source sequence(s)
    AP000355
    Related
    ENST00000326341.8

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    24429206..24495074 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001039784.1: Suppressed sequence

    Description
    NM_001039784.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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