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CCDC154 coiled-coil domain containing 154 [ Homo sapiens (human) ]

Gene ID: 645811, updated on 3-Apr-2024

Summary

Official Symbol
CCDC154provided by HGNC
Official Full Name
coiled-coil domain containing 154provided by HGNC
Primary source
HGNC:HGNC:34454
See related
Ensembl:ENSG00000197599 MIM:618740; AllianceGenome:HGNC:34454
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C16orf29
Summary
Predicted to be involved in bone mineralization involved in bone maturation. Predicted to act upstream of or within bone resorption; odontogenesis of dentin-containing tooth; and tooth eruption. Predicted to be located in early endosome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 3.7), spleen (RPKM 1.3) and 18 other tissues See more
Orthologs
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Genomic context

Location:
16p13.3
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (1434383..1444556, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (1449044..1459216, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (1484384..1494557, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:1470039-1470894 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:1470895-1471748 Neighboring gene ubiquinol-cytochrome c reductase complex assembly factor 4 Neighboring gene uncharacterized LOC105371044 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6984 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6985 Neighboring gene intestine-critical region regulatory element Neighboring gene proline and glutamate rich with coiled coil 1 Neighboring gene chloride voltage-gated channel 7 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6986 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:1524989-1525532 Neighboring gene RPS3A pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in bone mineralization involved in bone maturation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in bone resorption IEA
Inferred from Electronic Annotation
more info
 
involved_in odontogenesis of dentin-containing tooth IEA
Inferred from Electronic Annotation
more info
 
involved_in tooth eruption IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in early endosome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
coiled-coil domain-containing protein 154

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001143980.3NP_001137452.1  coiled-coil domain-containing protein 154

    See identical proteins and their annotated locations for NP_001137452.1

    Status: VALIDATED

    Source sequence(s)
    AL031600, AL032819
    Consensus CDS
    CCDS92082.1
    UniProtKB/Swiss-Prot
    A6NI56, G9JV18
    UniProtKB/TrEMBL
    A0A590PWR5
    Related
    ENSP00000373828.4, ENST00000389176.4
    Conserved Domains (1) summary
    pfam15450
    Location:55576
    CCDC154; Coiled-coil domain-containing protein 154

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    1434383..1444556 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    1449044..1459216 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054313689.1XP_054169664.1  coiled-coil domain-containing protein 154 isoform X1