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TMEM168 transmembrane protein 168 [ Homo sapiens (human) ]

Gene ID: 64418, updated on 5-Apr-2020

Summary

Official Symbol
TMEM168provided by HGNC
Official Full Name
transmembrane protein 168provided by HGNC
Primary source
HGNC:HGNC:25826
See related
Ensembl:ENSG00000146802
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in skin (RPKM 6.2), colon (RPKM 5.3) and 25 other tissues See more
Orthologs

Genomic context

See TMEM168 in Genome Data Viewer
Location:
7q31.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (112762377..112790403, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (112405364..112430768, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928012 Neighboring gene mitochondrial intermediate peptidase pseudogene 1 Neighboring gene base methyltransferase of 25S rRNA 2 homolog Neighboring gene heart tissue-associated transcript 17

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13576, DKFZp564C012

Gene Ontology Provided by GOA

Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
transport vesicle IDA
Inferred from Direct Assay
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001287497.2NP_001274426.1  transmembrane protein 168

    See identical proteins and their annotated locations for NP_001274426.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the supported protein. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC079621, AI698728, AK025482
    Consensus CDS
    CCDS5757.1
    UniProtKB/Swiss-Prot
    Q9H0V1
    UniProtKB/TrEMBL
    A0A024R716
    Related
    ENSP00000390696.1, ENST00000454074.5
    Conserved Domains (1) summary
    COG1480
    Location:175307
    YqfF; Membrane-associated HD superfamily phosphohydrolase [General function prediction only]
  2. NM_022484.6NP_071929.3  transmembrane protein 168

    See identical proteins and their annotated locations for NP_071929.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC079621, AI698728, AK314460, DC416793
    Consensus CDS
    CCDS5757.1
    UniProtKB/Swiss-Prot
    Q9H0V1
    UniProtKB/TrEMBL
    A0A024R716
    Related
    ENSP00000323068.4, ENST00000312814.11
    Conserved Domains (1) summary
    COG1480
    Location:175307
    YqfF; Membrane-associated HD superfamily phosphohydrolase [General function prediction only]

RNA

  1. NR_109840.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate exons in the 5' region, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet Refseq quality criteria.
    Source sequence(s)
    AC079621, AI698728, AK293311, DC416793

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    112762377..112790403 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017012523.2XP_016868012.1  transmembrane protein 168 isoform X1

    UniProtKB/Swiss-Prot
    Q9H0V1
    UniProtKB/TrEMBL
    A0A024R716
    Conserved Domains (1) summary
    COG1480
    Location:175307
    YqfF; Membrane-associated HD superfamily phosphohydrolase [General function prediction only]
  2. XM_024446869.1XP_024302637.1  transmembrane protein 168 isoform X3

    Related
    ENSP00000410307.1, ENST00000447395.5
  3. XM_017012524.2XP_016868013.1  transmembrane protein 168 isoform X2

RNA

  1. XR_001744854.2 RNA Sequence

  2. XR_001744853.2 RNA Sequence

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