U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TMEM168 transmembrane protein 168 [ Homo sapiens (human) ]

Gene ID: 64418, updated on 1-Mar-2024

Summary

Official Symbol
TMEM168provided by HGNC
Official Full Name
transmembrane protein 168provided by HGNC
Primary source
HGNC:HGNC:25826
See related
Ensembl:ENSG00000146802 AllianceGenome:HGNC:25826
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Located in transport vesicle. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in skin (RPKM 6.2), colon (RPKM 5.3) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See TMEM168 in Genome Data Viewer
Location:
7q31.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (112762377..112790393, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (114080668..114108691, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (112402432..112430448, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928012 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:112286368-112287110 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:112287111-112287851 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:112288143-112288644 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:112332541-112332766 Neighboring gene mitochondrial intermediate peptidase pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26514 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26515 Neighboring gene uncharacterized LOC124901729 Neighboring gene base methyltransferase of 25S rRNA 2 homolog Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26516 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26517 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26518 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26519 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:112556531-112557032 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:112557033-112557532 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18545 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:112579888-112580404

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ13576, DKFZp564C012

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables sodium channel regulator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in transport vesicle IDA
Inferred from Direct Assay
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001287497.2NP_001274426.1  transmembrane protein 168

    See identical proteins and their annotated locations for NP_001274426.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the supported protein. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC079621, AI698728, AK025482
    Consensus CDS
    CCDS5757.1
    UniProtKB/Swiss-Prot
    A4D0T9, B4DDS0, Q8NEK4, Q9H0V1, Q9H8J2
    Related
    ENSP00000390696.1, ENST00000454074.5
    Conserved Domains (1) summary
    cd21494
    Location:17695
    TMEM168; Transmembrane (TMEM) protein family 168
  2. NM_022484.6NP_071929.3  transmembrane protein 168

    See identical proteins and their annotated locations for NP_071929.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC079621, AI698728, AK314460, DC416793
    Consensus CDS
    CCDS5757.1
    UniProtKB/Swiss-Prot
    A4D0T9, B4DDS0, Q8NEK4, Q9H0V1, Q9H8J2
    Related
    ENSP00000323068.4, ENST00000312814.11
    Conserved Domains (1) summary
    cd21494
    Location:17695
    TMEM168; Transmembrane (TMEM) protein family 168

RNA

  1. NR_109840.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate exons in the 5' region, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet Refseq quality criteria.
    Source sequence(s)
    AC079621, AI698728, AK293311, DC416793

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    112762377..112790393 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017012523.3XP_016868012.1  transmembrane protein 168 isoform X1

    UniProtKB/Swiss-Prot
    A4D0T9, B4DDS0, Q8NEK4, Q9H0V1, Q9H8J2
    Conserved Domains (1) summary
    cd21494
    Location:17695
    TMEM168; Transmembrane (TMEM) protein family 168
  2. XM_047420710.1XP_047276666.1  transmembrane protein 168 isoform X1

    UniProtKB/Swiss-Prot
    A4D0T9, B4DDS0, Q8NEK4, Q9H0V1, Q9H8J2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    114080668..114108691 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054358804.1XP_054214779.1  transmembrane protein 168 isoform X1

    UniProtKB/Swiss-Prot
    A4D0T9, B4DDS0, Q8NEK4, Q9H0V1, Q9H8J2
  2. XM_054358803.1XP_054214778.1  transmembrane protein 168 isoform X1

    UniProtKB/Swiss-Prot
    A4D0T9, B4DDS0, Q8NEK4, Q9H0V1, Q9H8J2