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RGS18 regulator of G protein signaling 18 [ Homo sapiens (human) ]

Gene ID: 64407, updated on 1-Jun-2020


Official Symbol
RGS18provided by HGNC
Official Full Name
regulator of G protein signaling 18provided by HGNC
Primary source
See related
Ensembl:ENSG00000150681 MIM:607192
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Broad expression in spleen (RPKM 9.4), appendix (RPKM 6.5) and 15 other tissues See more

Genomic context

See RGS18 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (192158462..192187172)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (192127592..192154945)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2770 Neighboring gene uncharacterized LOC105371661 Neighboring gene uncharacterized LOC105371662 Neighboring gene ATP binding cassette subfamily E member 1 pseudogene

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IEA
Inferred from Electronic Annotation
more info
GTPase activity TAS
Traceable Author Statement
more info
protein binding IPI
Inferred from Physical Interaction
more info
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
regulation of G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
plasma membrane TAS
Traceable Author Statement
more info

General protein information

Preferred Names
regulator of G-protein signaling 18
regulator of G-protein signalling 13
regulator of G-protein signalling 18

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130782.3NP_570138.1  regulator of G-protein signaling 18

    See identical proteins and their annotated locations for NP_570138.1

    Status: REVIEWED

    Source sequence(s)
    AF076642, AF268036, AV715708, BC020632
    Consensus CDS
    ENSP00000356430.3, ENST00000367460.4
    Conserved Domains (1) summary
    RGS_RGS18; Regulator of G protein signaling (RGS) domain found in the RGS18 protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly


  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509891.3XP_011508193.1  regulator of G-protein signaling 18 isoform X1

    Conserved Domains (1) summary
    RGS; Regulator of G protein signaling (RGS) domain superfamily
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