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RGS18 regulator of G protein signaling 18 [ Homo sapiens (human) ]

Gene ID: 64407, updated on 9-Dec-2024

Summary

Official Symbol
RGS18provided by HGNC
Official Full Name
regulator of G protein signaling 18provided by HGNC
Primary source
HGNC:HGNC:14261
See related
Ensembl:ENSG00000150681 MIM:607192; AllianceGenome:HGNC:14261
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RGS13
Summary
This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Expression
Broad expression in spleen (RPKM 9.4), appendix (RPKM 6.5) and 15 other tissues See more
Orthologs
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Genomic context

See RGS18 in Genome Data Viewer
Location:
1q31.2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (192158462..192185815)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (191505098..191532461)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (192127592..192154945)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2770 Neighboring gene MPRA-validated peak600 silencer Neighboring gene MPRA-validated peak601 silencer Neighboring gene uncharacterized LOC105371661 Neighboring gene Sharpr-MPRA regulatory region 5305 Neighboring gene MPRA-validated peak603 silencer Neighboring gene MPRA-validated peak604 silencer Neighboring gene MPRA-validated peak605 silencer Neighboring gene uncharacterized LOC105371662 Neighboring gene ATP binding cassette subfamily E member 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity TAS
Traceable Author Statement
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
regulator of G-protein signaling 18
Names
regulator of G-protein signalling 13
regulator of G-protein signalling 18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130782.3NP_570138.1  regulator of G-protein signaling 18

    See identical proteins and their annotated locations for NP_570138.1

    Status: REVIEWED

    Source sequence(s)
    AF076642, AF268036, AV715708, BC020632
    Consensus CDS
    CCDS1374.1
    UniProtKB/Swiss-Prot
    B2RD23, Q9NS28
    UniProtKB/TrEMBL
    A8K7K0, B3KQ04
    Related
    ENSP00000356430.3, ENST00000367460.4
    Conserved Domains (1) summary
    cd08712
    Location:87200
    RGS_RGS18; Regulator of G protein signaling (RGS) domain found in the RGS18 protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    192158462..192185815
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    191505098..191532461
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054338213.1XP_054194188.1  regulator of G-protein signaling 18 isoform X1