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AZI2 5-azacytidine induced 2 [ Homo sapiens (human) ]

Gene ID: 64343, updated on 5-Jul-2020

Summary

Official Symbol
AZI2provided by HGNC
Official Full Name
5-azacytidine induced 2provided by HGNC
Primary source
HGNC:HGNC:24002
See related
Ensembl:ENSG00000163512 MIM:609916
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AZ2; NAP1; TILP
Summary
AZI2, or NAP1, contributes to the activation of NFKB (see MIM 164011)-dependent gene expression by activating IKK-related kinases, such as NAK (TBK1; MIM 604834) (Fujita et al., 2003 [PubMed 14560022]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in fat (RPKM 22.5), thyroid (RPKM 15.3) and 25 other tissues See more
Orthologs

Genomic context

See AZI2 in Genome Data Viewer
Location:
3p24.1
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (28321047..28349278, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (28363844..28390915, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1967 Neighboring gene uncharacterized LOC105377008 Neighboring gene C-X9-C motif containing 1 Neighboring gene zinc finger CW-type and PWWP domain containing 2 Neighboring gene family with sequence similarity 96 member A pseudogene 1 Neighboring gene ribosomal protein L34 pseudogene 11

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
T cell activation IEA
Inferred from Electronic Annotation
more info
 
dendritic cell differentiation IEA
Inferred from Electronic Annotation
more info
 
dendritic cell proliferation IEA
Inferred from Electronic Annotation
more info
 
interferon-alpha production IEA
Inferred from Electronic Annotation
more info
 
interferon-gamma production IEA
Inferred from Electronic Annotation
more info
 
interleukin-6 production IEA
Inferred from Electronic Annotation
more info
 
mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
tumor necrosis factor production IEA
Inferred from Electronic Annotation
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
5-azacytidine-induced protein 2
Names
5-azacytidine induced gene 2
NAK-associated protein 1
NF-kappa-B-activating kinase-associated protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134432.2NP_001127904.1  5-azacytidine-induced protein 2 isoform b

    See identical proteins and their annotated locations for NP_001127904.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (b) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    BX327318, BX386357, CF528511
    Consensus CDS
    CCDS46782.1
    UniProtKB/Swiss-Prot
    Q9H6S1
    Related
    ENSP00000391696.2, ENST00000420543.6
    Conserved Domains (2) summary
    cl19219
    Location:160221
    DUF342; Protein of unknown function (DUF342)
    cl25732
    Location:46233
    SMC_N; RecF/RecN/SMC N terminal domain
  2. NM_001134433.2NP_001127905.1  5-azacytidine-induced protein 2 isoform c

    See identical proteins and their annotated locations for NP_001127905.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (c) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    CB995808, CF528511, DA485515
    Consensus CDS
    CCDS46783.1
    UniProtKB/Swiss-Prot
    Q9H6S1
    Related
    ENSP00000335609.6, ENST00000334100.10
  3. NM_001271650.2NP_001258579.1  5-azacytidine-induced protein 2 isoform d

    See identical proteins and their annotated locations for NP_001258579.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate exon and uses an alternate splice site in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (d) is shorter than isoform a.
    Source sequence(s)
    AC098616, BM546093, BX648471, DA485515
    Conserved Domains (2) summary
    pfam12845
    Location:104153
    TBD; TBD domain
    cl19219
    Location:48121
    DUF342; Protein of unknown function (DUF342)
  4. NM_022461.5NP_071906.1  5-azacytidine-induced protein 2 isoform a

    See identical proteins and their annotated locations for NP_071906.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC098616, AK025592, AK290637, BX648471
    Consensus CDS
    CCDS2647.1
    UniProtKB/Swiss-Prot
    Q9H6S1
    Related
    ENSP00000419371.1, ENST00000479665.6
    Conserved Domains (2) summary
    pfam12845
    Location:216265
    TBD; TBD domain
    cl19219
    Location:160233
    DUF342; Protein of unknown function (DUF342)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    28321047..28349278 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005265392.3XP_005265449.1  5-azacytidine-induced protein 2 isoform X2

    See identical proteins and their annotated locations for XP_005265449.1

    UniProtKB/Swiss-Prot
    Q9H6S1
    Related
    ENST00000295748.7
    Conserved Domains (2) summary
    pfam12845
    Location:216265
    TBD; TBD domain
    cl19219
    Location:160233
    DUF342; Protein of unknown function (DUF342)
  2. XM_011534009.2XP_011532311.1  5-azacytidine-induced protein 2 isoform X1

    Conserved Domains (2) summary
    pfam12845
    Location:219268
    TBD; TBD domain
    cl19219
    Location:163236
    DUF342; Protein of unknown function (DUF342)
  3. XM_024453707.1XP_024309475.1  5-azacytidine-induced protein 2 isoform X5

    Related
    ENSP00000412820.1, ENST00000414162.5
  4. XM_011534011.2XP_011532313.1  5-azacytidine-induced protein 2 isoform X4

  5. XM_011534010.2XP_011532312.1  5-azacytidine-induced protein 2 isoform X3

    Conserved Domains (1) summary
    cl19219
    Location:163224
    DUF342; Protein of unknown function (DUF342)
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