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ARHGAP9 Rho GTPase activating protein 9 [ Homo sapiens (human) ]

Gene ID: 64333, updated on 21-Apr-2019

Summary

Official Symbol
ARHGAP9provided by HGNC
Official Full Name
Rho GTPase activating protein 9provided by HGNC
Primary source
HGNC:HGNC:14130
See related
Ensembl:ENSG00000123329 MIM:610576
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
10C; RGL1
Summary
This gene encodes a member of the Rho-GAP family of GTPase activating proteins. The protein has substantial GAP activity towards several Rho-family GTPases in vitro, converting them to an inactive GDP-bound state. It is implicated in regulating adhesion of hematopoietic cells to the extracellular matrix. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in spleen (RPKM 23.2), bone marrow (RPKM 22.4) and 14 other tissues See more
Orthologs

Genomic context

See ARHGAP9 in Genome Data Viewer
Location:
12q13.3
Exon count:
22
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (57472255..57488814, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (57866038..57882756, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene inhibin subunit beta C Neighboring gene inhibin subunit beta E Neighboring gene GLI family zinc finger 1 Neighboring gene methionyl-tRNA synthetase Neighboring gene microRNA 6758 Neighboring gene DNA damage inducible transcript 3 Neighboring gene microRNA 616

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
    Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
  • Regulation of RAC1 activity, organism-specific biosystem (from Pathway Interaction Database)
    Regulation of RAC1 activity, organism-specific biosystem
    Regulation of RAC1 activity
  • Regulation of RhoA activity, organism-specific biosystem (from Pathway Interaction Database)
    Regulation of RhoA activity, organism-specific biosystem
    Regulation of RhoA activity
  • Rho GTPase cycle, organism-specific biosystem (from REACTOME)
    Rho GTPase cycle, organism-specific biosystemThe cycling of Rho GTPases is tightly controlled by three classes of protein. These are (1) guanine nucleotide dissociation inhibitors or GDIs, which maintain Rho proteins in an inactive state in the...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC1295, FLJ16525

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol-3,4,5-trisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
neutrophil degranulation TAS
Traceable Author Statement
more info
 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
secretory granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
rho GTPase-activating protein 9
Names
rho-type GTPase-activating protein 9

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023205.2 RefSeqGene

    Range
    13943..21560
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001080156.2NP_001073625.1  rho GTPase-activating protein 9 isoform 3

    See identical proteins and their annotated locations for NP_001073625.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at a downstream start codon, compared to variant 1. The resulting isoform (3) has a shorter N-terminus compared to isoform 1. Variants 3 and 11 both encode the same isoform (3).
    Source sequence(s)
    AB030239, AC022506, CB528354, DC390315
    Consensus CDS
    CCDS44928.1
    UniProtKB/Swiss-Prot
    Q9BRR9
    Related
    ENSP00000397950.2, ENST00000430041.6
    Conserved Domains (4) summary
    cd04403
    Location:337541
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cd13233
    Location:140252
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:139251
    PH; PH domain
    pfam00397
    Location:3561
    WW; WW domain
  2. NM_001080157.1NP_001073626.1  rho GTPase-activating protein 9 isoform 2

    See identical proteins and their annotated locations for NP_001073626.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. The resulting isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AB030239, AK092763, CB528354, DA675251
    Consensus CDS
    CCDS44929.1
    UniProtKB/Swiss-Prot
    Q9BRR9
    Related
    ENSP00000394307.2, ENST00000424809.6
    Conserved Domains (4) summary
    cd13233
    Location:324436
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:323435
    PH; PH domain
    cl02570
    Location:521639
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
    cl17036
    Location:2682
    SH3; Src Homology 3 domain superfamily
  3. NM_001319850.2NP_001306779.2  rho GTPase-activating protein 9 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, initiates translation at an alternate start codon and contains multiple additional 5' coding exons, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (4) has a longer N-terminus and is longer, compared to isoform 1.
    Source sequence(s)
    AC022506, BC006107
    Consensus CDS
    CCDS81705.1
    Related
    ENSP00000377386.2, ENST00000393797.6
  4. NM_001319851.1NP_001306780.1  rho GTPase-activating protein 9 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion and contains an alternate segment in the 5' coding region, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. It initiates translation at a downstream start codon. The encoded isoform (5) has a shorter N-terminus and is shorter, compared to isoform 1.
    Source sequence(s)
    AC022506, AK057573, BC006107, CB528354, CF143873, DC390315
    UniProtKB/Swiss-Prot
    Q9BRR9
    UniProtKB/TrEMBL
    B3KQ74
    Conserved Domains (3) summary
    cd04403
    Location:210414
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cd13233
    Location:1106
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:8105
    PH; PH domain
  5. NM_001319852.1NP_001306781.1  rho GTPase-activating protein 9 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at a downstream start codon, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (6) has a shorter N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC022506
    UniProtKB/Swiss-Prot
    Q9BRR9
    Conserved Domains (4) summary
    cd04403
    Location:356560
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cd13233
    Location:140252
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:139251
    PH; PH domain
    pfam00397
    Location:3561
    WW; WW domain
  6. NM_001367422.1NP_001354351.1  rho GTPase-activating protein 9 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC022506
  7. NM_001367423.1NP_001354352.1  rho GTPase-activating protein 9 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC022506
  8. NM_001367424.1NP_001354353.1  rho GTPase-activating protein 9 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC022506
  9. NM_001367425.1NP_001354354.1  rho GTPase-activating protein 9 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC022506
  10. NM_001367426.1NP_001354355.1  rho GTPase-activating protein 9 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), as well as variant 3, encodes isoform 3.
    Source sequence(s)
    AC022506
  11. NM_032496.4NP_115885.2  rho GTPase-activating protein 9 isoform 1

    See identical proteins and their annotated locations for NP_115885.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AB051853, DC408597
    Consensus CDS
    CCDS8941.2
    UniProtKB/Swiss-Prot
    Q9BRR9
    Related
    ENSP00000377380.3, ENST00000393791.8
    Conserved Domains (5) summary
    cd12143
    Location:2682
    SH3_ARHGAP9; Src Homology 3 domain of Rho GTPase-activating protein 9 and similar proteins
    cd04403
    Location:521725
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cd13233
    Location:324436
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:323435
    PH; PH domain
    pfam00397
    Location:219245
    WW; WW domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    Range
    57472255..57488814 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538659.2XP_011536961.1  rho GTPase-activating protein 9 isoform X4

    See identical proteins and their annotated locations for XP_011536961.1

    UniProtKB/Swiss-Prot
    Q9BRR9
    Conserved Domains (4) summary
    cd13233
    Location:324436
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:323435
    PH; PH domain
    cl02570
    Location:521639
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
    cl17036
    Location:2682
    SH3; Src Homology 3 domain superfamily
  2. XM_011538656.2XP_011536958.1  rho GTPase-activating protein 9 isoform X1

    See identical proteins and their annotated locations for XP_011536958.1

    UniProtKB/Swiss-Prot
    Q9BRR9
    Conserved Domains (5) summary
    cd12143
    Location:2682
    SH3_ARHGAP9; Src Homology 3 domain of Rho GTPase-activating protein 9 and similar proteins
    cd04403
    Location:521725
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cd13233
    Location:324436
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:323435
    PH; PH domain
    pfam00397
    Location:219245
    WW; WW domain
  3. XM_011538657.2XP_011536959.1  rho GTPase-activating protein 9 isoform X2

    Conserved Domains (4) summary
    cd12143
    Location:2682
    SH3_ARHGAP9; Src Homology 3 domain of Rho GTPase-activating protein 9 and similar proteins
    cd04403
    Location:509713
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cd13233
    Location:293405
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:292404
    PH; PH domain
  4. XM_011538658.2XP_011536960.1  rho GTPase-activating protein 9 isoform X3

    Conserved Domains (5) summary
    cd12143
    Location:2682
    SH3_ARHGAP9; Src Homology 3 domain of Rho GTPase-activating protein 9 and similar proteins
    cd04403
    Location:490694
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cd13233
    Location:293405
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:292404
    PH; PH domain
    pfam00397
    Location:219245
    WW; WW domain
  5. XM_017019800.1XP_016875289.1  rho GTPase-activating protein 9 isoform X5

    UniProtKB/Swiss-Prot
    Q9BRR9
    Conserved Domains (4) summary
    cd04403
    Location:356560
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cd13233
    Location:140252
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:139251
    PH; PH domain
    pfam00397
    Location:3561
    WW; WW domain
  6. XM_017019804.1XP_016875293.1  rho GTPase-activating protein 9 isoform X10

  7. XM_017019802.1XP_016875291.1  rho GTPase-activating protein 9 isoform X8

  8. XM_005269084.2XP_005269141.1  rho GTPase-activating protein 9 isoform X7

    See identical proteins and their annotated locations for XP_005269141.1

    Conserved Domains (4) summary
    cd04403
    Location:325529
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cd13233
    Location:109221
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:108220
    PH; PH domain
    pfam00397
    Location:3561
    WW; WW domain
  9. XM_005269085.2XP_005269142.1  rho GTPase-activating protein 9 isoform X7

    See identical proteins and their annotated locations for XP_005269142.1

    Conserved Domains (4) summary
    cd04403
    Location:325529
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cd13233
    Location:109221
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:108220
    PH; PH domain
    pfam00397
    Location:3561
    WW; WW domain
  10. XM_017019803.1XP_016875292.1  rho GTPase-activating protein 9 isoform X9

  11. XM_017019801.1XP_016875290.1  rho GTPase-activating protein 9 isoform X6

    UniProtKB/Swiss-Prot
    Q9BRR9
    Conserved Domains (4) summary
    cd04403
    Location:337541
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cd13233
    Location:140252
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:139251
    PH; PH domain
    pfam00397
    Location:3561
    WW; WW domain
  12. XM_005269083.2XP_005269140.1  rho GTPase-activating protein 9 isoform X5

    See identical proteins and their annotated locations for XP_005269140.1

    UniProtKB/Swiss-Prot
    Q9BRR9
    Conserved Domains (4) summary
    cd04403
    Location:356560
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cd13233
    Location:140252
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:139251
    PH; PH domain
    pfam00397
    Location:3561
    WW; WW domain

RNA

  1. XR_001748843.1 RNA Sequence

  2. XR_001748842.1 RNA Sequence

  3. XR_001748841.1 RNA Sequence

  4. XR_001748840.1 RNA Sequence

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