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TRIM64B tripartite motif containing 64B [ Homo sapiens (human) ]

Gene ID: 642446, updated on 13-Aug-2022

Summary

Official Symbol
TRIM64Bprovided by HGNC
Official Full Name
tripartite motif containing 64Bprovided by HGNC
Primary source
HGNC:HGNC:37147
See related
Ensembl:ENSG00000189253 AllianceGenome:HGNC:37147
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response; protein ubiquitination; and regulation of gene expression. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See TRIM64B in Genome Data Viewer
Location:
11q14.3
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (89870438..89878487, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (89790143..89798190, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (89603606..89611655, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene tripartite motif-containing 51B, pseudogene Neighboring gene ANKRD33B pseudogene 8 Neighboring gene cell adhesion associated, oncogene regulated pseudogene Neighboring gene MT-ND1 pseudogene 35

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
putative tripartite motif-containing protein 64B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164397.3NP_001157869.1  putative tripartite motif-containing protein 64B

    See identical proteins and their annotated locations for NP_001157869.1

    Status: VALIDATED

    Source sequence(s)
    AP005435
    Consensus CDS
    CCDS53693.1
    UniProtKB/Swiss-Prot
    A6NI03
    Related
    ENSP00000332969.6, ENST00000329862.7
    Conserved Domains (4) summary
    cd19783
    Location:86138
    Bbox2_TRIM43-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins TRIM43, TRIM48, TRIM49, TRIM51, TRIM64, TRIM77 and similar proteins
    pfam05557
    Location:132232
    MAD; Mitotic checkpoint protein
    cd16603
    Location:967
    RING-HC_TRIM43-like_C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM43, TRIM48, TRIM49, TRIM51, TRIM64 and similar proteins
    cl02614
    Location:284445
    SPRY; SPRY domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    89870438..89878487 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011542955.3XP_011541257.1  putative tripartite motif-containing protein 64B isoform X1

    Conserved Domains (1) summary
    cl02614
    Location:142303
    SPRY; SPRY domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    89790143..89798190 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)