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LHX5 LIM homeobox 5 [ Homo sapiens (human) ]

Gene ID: 64211, updated on 25-Jan-2024

Summary

Official Symbol
LHX5provided by HGNC
Official Full Name
LIM homeobox 5provided by HGNC
Primary source
HGNC:HGNC:14216
See related
Ensembl:ENSG00000089116 MIM:605992; AllianceGenome:HGNC:14216
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a protein belonging to a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and be involved in the control of differentiation and development of the forebrain. In mice, this protein is essential for the regulation of precursor cell proliferation and the control of neuronal differentiation and migration during hippocampal development. This protein is involved in learning and motor functions in adult mice. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See LHX5 in Genome Data Viewer
Location:
12q24.13
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (113462033..113471871, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (113438040..113447878, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (113899838..113909676, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7074 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:113839129-113839630 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:113839631-113840130 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:113851189-113851372 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:113855942-113856442 Neighboring gene serine dehydratase Neighboring gene serine dehydratase like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:113905667-113906660 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:113908758-113909558 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:113916060-113917027 Neighboring gene LHX5 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:113938319-113938819 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:114025396-114026173 Neighboring gene MPRA-validated peak1973 silencer Neighboring gene uncharacterized LOC105369990 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:114079299-114079817

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Clone Names

  • MGC129689

Gene Ontology Provided by GOA

Component Evidence Code Pubs
part_of chromatin ISA
Inferred from Sequence Alignment
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
LIM/homeobox protein Lhx5
Names
LIM homeobox protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022363.3NP_071758.1  LIM/homeobox protein Lhx5

    See identical proteins and their annotated locations for NP_071758.1

    Status: REVIEWED

    Source sequence(s)
    AC009773
    Consensus CDS
    CCDS9171.1
    UniProtKB/Swiss-Prot
    Q32MA4, Q9H2C1
    Related
    ENSP00000261731.2, ENST00000261731.4
    Conserved Domains (4) summary
    cd09367
    Location:556
    LIM1_Lhx1_Lhx5; The first LIM domain of Lhx1 (also known as Lim1) and Lhx5
    cd09375
    Location:64119
    LIM2_Lhx1_Lhx5; The second LIM domain of Lhx1 (also known as Lim1) and Lhx5
    PHA03378
    Location:301392
    PHA03378; EBNA-3B; Provisional
    pfam00046
    Location:183237
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    113462033..113471871 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    113438040..113447878 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)