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DPEP2 dipeptidase 2 [ Homo sapiens (human) ]

Gene ID: 64174, updated on 2-Oct-2018

Summary

Official Symbol
DPEP2provided by HGNC
Official Full Name
dipeptidase 2provided by HGNC
Primary source
HGNC:HGNC:23028
See related
Ensembl:ENSG00000167261 MIM:609925; Vega:OTTHUMG00000137542
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MBD2
Summary
DPEP2 belongs to the membrane-bound dipeptidase (EC 3.4.13.19) family. These enzymes hydrolyze a variety of dipeptides, including leukotriene D4, the beta-lactam ring of some antibiotics, and cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation (Habib et al., 2003 [PubMed 12738806]).[supplied by OMIM, Mar 2008]
Expression
Broad expression in spleen (RPKM 6.2), lymph node (RPKM 3.2) and 14 other tissues See more
Orthologs

Genomic context

See DPEP2 in Genome Data Viewer
Location:
16q22.1
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (67987390..68000644, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (68021293..68034493, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene lecithin-cholesterol acyltransferase Neighboring gene solute carrier family 12 member 4 Neighboring gene dipeptidase 3 Neighboring gene lysyl-tRNA synthetase pseudogene 3 Neighboring gene DPEP2 neighbor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Phenotypes

NHGRI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
NHGRI GWA Catalog
Newly identified loci that influence lipid concentrations and risk of coronary artery disease.
NHGRI GWA Catalog

Pathways from BioSystems

  • Aflatoxin activation and detoxification, organism-specific biosystem (from REACTOME)
    Aflatoxin activation and detoxification, organism-specific biosystemAflatoxins are among the principal mycotoxins produced as secondary metabolites by the molds Aspergillus flavus and Aspergillus parasiticus that contaminate economically important food and feed crops...
  • Arachidonic acid metabolism, organism-specific biosystem (from REACTOME)
    Arachidonic acid metabolism, organism-specific biosystemEicosanoids, oxygenated, 20-carbon fatty acids, are autocrine and paracrine signaling molecules that modulate physiological processes including pain, fever, inflammation, blood clot formation, smooth...
  • Biological oxidations, organism-specific biosystem (from REACTOME)
    Biological oxidations, organism-specific biosystemAll organisms are constantly exposed to foreign chemicals every day. These can be man-made (drugs, industrial chemicals) or natural (alkaloids, toxins from plants and animals). Uptake is usually via ...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • Synthesis of Leukotrienes (LT) and Eoxins (EX), organism-specific biosystem (from REACTOME)
    Synthesis of Leukotrienes (LT) and Eoxins (EX), organism-specific biosystemLeukotrienes (LTs) are biologically active molecules formed in response to inflammatory stimuli. They cause contraction of bronchial smooth muscles, stimulation of vascular permeability, and attracti...
  • leukotriene biosynthesis, organism-specific biosystem (from BIOCYC)
    leukotriene biosynthesis, organism-specific biosystemLeukotrienes are made by cells of the immune system, mainly the mediators of inflammation like polymorphonuclear leukocytes, macrophages and mast cells. Cellular activation during inflammation leads ...
  • leukotriene biosynthesis, conserved biosystem (from BIOCYC)
    leukotriene biosynthesis, conserved biosystemLeukotrienes are proinflammatory metabolites of arachidonic acid that activate and amplify innate and adaptive immune responses. They also have roles in pathologic immune responses, mediating contrac...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
dipeptidase activity IEA
Inferred from Electronic Annotation
more info
 
dipeptidyl-peptidase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
metalloexopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dipeptidase 2
NP_001311088.1
NP_071750.1
XP_005256147.2
XP_011521568.1
XP_011521570.1
XP_011521573.1
XP_011521574.1
XP_011521575.1
XP_011521576.1
XP_016879031.1
XP_016879032.1
XP_016879033.1
XP_016879034.1
XP_016879036.1
XP_024306140.1
XP_024306141.1
XP_024306142.1
XP_024306144.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001324159.1NP_001311088.1  dipeptidase 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC040162, KC877614
  2. NM_022355.3NP_071750.1  dipeptidase 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_071750.1

    Status: VALIDATED

    Source sequence(s)
    AJ295149, BP299049, CB528462
    Consensus CDS
    CCDS10857.1
    UniProtKB/Swiss-Prot
    Q9H4A9
    UniProtKB/TrEMBL
    A0A024R6Y5
    Related
    ENSP00000377430.1, OTTHUMP00000174846, ENST00000393847.5, OTTHUMT00000268873
    Conserved Domains (1) summary
    pfam01244
    Location:78399
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

RNA

  1. NR_136706.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AA404265, AC040162, AK092884
    Related
    ENST00000575203.5, OTTHUMT00000437025

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    67987390..68000644 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450373.1XP_024306141.1  dipeptidase 2 isoform X1

    Conserved Domains (1) summary
    pfam01244
    Location:78412
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)
  2. XM_011523274.3XP_011521576.1  dipeptidase 2 isoform X9

    Conserved Domains (1) summary
    cl00281
    Location:18204
    metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...
  3. XM_011523273.3XP_011521575.1  dipeptidase 2 isoform X8

    See identical proteins and their annotated locations for XP_011521575.1

    Conserved Domains (1) summary
    pfam01244
    Location:1254
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)
  4. XM_011523272.3XP_011521574.1  dipeptidase 2 isoform X8

    See identical proteins and their annotated locations for XP_011521574.1

    Conserved Domains (1) summary
    pfam01244
    Location:1254
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)
  5. XM_024450376.1XP_024306144.1  dipeptidase 2 isoform X10

    Conserved Domains (1) summary
    cl00281
    Location:18191
    metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...
  6. XM_017023544.1XP_016879033.1  dipeptidase 2 isoform X5

    Conserved Domains (1) summary
    pfam01244
    Location:5289
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)
  7. XM_017023543.1XP_016879032.1  dipeptidase 2 isoform X4

    Conserved Domains (1) summary
    pfam01244
    Location:15296
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)
  8. XM_017023547.1XP_016879036.1  dipeptidase 2 isoform X11

  9. XM_024450374.1XP_024306142.1  dipeptidase 2 isoform X1

    Conserved Domains (1) summary
    pfam01244
    Location:78412
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)
  10. XM_011523266.1XP_011521568.1  dipeptidase 2 isoform X1

    See identical proteins and their annotated locations for XP_011521568.1

    Conserved Domains (1) summary
    pfam01244
    Location:78412
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)
  11. XM_017023545.1XP_016879034.1  dipeptidase 2 isoform X8

    Conserved Domains (1) summary
    pfam01244
    Location:1254
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)
  12. XM_024450372.1XP_024306140.1  dipeptidase 2 isoform X1

    Conserved Domains (1) summary
    pfam01244
    Location:78412
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)
  13. XM_017023542.2XP_016879031.1  dipeptidase 2 isoform X3

  14. XM_011523271.3XP_011521573.1  dipeptidase 2 isoform X7

    Conserved Domains (1) summary
    pfam01244
    Location:78306
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)
  15. XM_005256090.5XP_005256147.2  dipeptidase 2 isoform X6

    Conserved Domains (1) summary
    pfam01244
    Location:78356
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)
  16. XM_011523268.3XP_011521570.1  dipeptidase 2 isoform X2

    Conserved Domains (1) summary
    pfam01244
    Location:78404
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

RNA

  1. XR_933390.3 RNA Sequence

  2. XR_933389.3 RNA Sequence

  3. XR_933391.3 RNA Sequence

  4. XR_933392.3 RNA Sequence

  5. XR_243420.5 RNA Sequence

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