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DPEP2 dipeptidase 2 [ Homo sapiens (human) ]

Gene ID: 64174, updated on 27-Aug-2024

Summary

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Official Symbol
DPEP2provided by HGNC
Official Full Name
dipeptidase 2provided by HGNC
Primary source
HGNC:HGNC:23028
See related
Ensembl:ENSG00000167261 MIM:609925; AllianceGenome:HGNC:23028
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MBD2
Summary
DPEP2 belongs to the membrane-bound dipeptidase (EC 3.4.13.19) family. These enzymes hydrolyze a variety of dipeptides, including leukotriene D4, the beta-lactam ring of some antibiotics, and cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation (Habib et al., 2003 [PubMed 12738806]).[supplied by OMIM, Mar 2008]
Expression
Broad expression in spleen (RPKM 6.2), lymph node (RPKM 3.2) and 14 other tissues See more
Orthologs
all
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Genomic context

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Location:
16q22.1
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (67987390..68000619, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (73783178..73796408, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (68021293..68034522, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene lecithin-cholesterol acyltransferase Neighboring gene solute carrier family 12 member 4 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:67992978-67994177 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:67998939-67999110 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:68000156-68000674 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7633 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7634 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7635 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:68013726-68014226 Neighboring gene dipeptidase 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7636 Neighboring gene Sharpr-MPRA regulatory region 6452 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10999 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11000 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11001 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7637 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:68031810-68032326 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:68040489-68041262 Neighboring gene lysyl-tRNA synthetase 1 pseudogene 3 Neighboring gene DPEP2 neighbor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Structure of human DPEP3 in complex with the SC-003 antibody Fab fragment reveals basis for lack of dipeptidase activity. Hayashi K, et al. J Struct Biol, 2020 Jul 1. PMID 32325220
  2. Identification of two additional members of the membrane-bound dipeptidase family. Habib GM, et al. FASEB J, 2003 Jul. PMID 12738806
  3. Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Willer CJ, et al. Nat Genet, 2008 Feb. PMID 18193043, Free PMC Article
  4. Novel interactive partners of neuroligin 3: new aspects for pathogenesis of autism. Shen C, et al. J Mol Neurosci, 2015 May. PMID 25464930
  5. The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3. Rahman S, et al. Mol Cell Biol, 2011 Jul. PMID 21555454, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dipeptidase-2 is a prognostic marker in lung adenocarcinoma that is correlated with its sensitivity to cisplatin.
    Title: Dipeptidase‑2 is a prognostic marker in lung adenocarcinoma that is correlated with its sensitivity to cisplatin.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
EBI GWAS Catalog
Newly identified loci that influence lipid concentrations and risk of coronary artery disease.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables dipeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables dipeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metallodipeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in leukotriene D4 catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in leukotriene metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dipeptidase 2
NP_001311088.1
NP_001356586.1
NP_071750.1
XP_005256147.2
XP_011521568.1
XP_011521570.1
XP_011521573.1
XP_011521575.1
XP_011521576.1
XP_016879034.1
XP_016879036.1
XP_024306140.1
XP_024306141.1
XP_024306142.1
XP_024306144.1
XP_047290415.1
XP_047290416.1
XP_047290417.1
XP_047290418.1
XP_047290419.1
XP_047290420.1
XP_047290421.1
XP_054169597.1
XP_054169598.1
XP_054169599.1
XP_054169600.1
XP_054169601.1
XP_054169602.1
XP_054169603.1
XP_054169604.1
XP_054169605.1
XP_054169606.1
XP_054169607.1
XP_054169608.1
XP_054169609.1
XP_054169610.1
XP_054169611.1
XP_054169612.1
XP_054169613.1
XP_054169614.1
XP_054169615.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001324159.2 → NP_001311088.1  dipeptidase 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC040162, KC877614
    Conserved Domains (1) summary
    pfam01244
    Location:1 → 241
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

  2. NM_001369657.1 → NP_001356586.1  dipeptidase 2 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC040162, KC877614
    Consensus CDS
    CCDS10857.1
    UniProtKB/Swiss-Prot
    A0A024R6Y5, B2RCF8, B3KS59, I3L248, Q6UX92, Q8TC95, Q9H4A9
    Related
    ENSP00000458977.1, ENST00000572888.5
    Conserved Domains (1) summary
    pfam01244
    Location:78 → 399
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

  3. NM_022355.4 → NP_071750.1  dipeptidase 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_071750.1

    Status: VALIDATED

    Source sequence(s)
    AJ295149, BP299049, CB528462
    Consensus CDS
    CCDS10857.1
    UniProtKB/Swiss-Prot
    A0A024R6Y5, B2RCF8, B3KS59, I3L248, Q6UX92, Q8TC95, Q9H4A9
    Related
    ENSP00000377430.1, ENST00000393847.6
    Conserved Domains (1) summary
    pfam01244
    Location:78 → 399
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

RNA

  1. NR_136706.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AA404265, AC040162, AK092884
    Related
    ENST00000575203.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    67987390..68000619 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017023547.2 → XP_016879036.1  dipeptidase 2 isoform X14

  2. XM_024450376.2 → XP_024306144.1  dipeptidase 2 isoform X13

    Conserved Domains (1) summary
    cl00281
    Location:18 → 191
    metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

  3. XM_011523274.4 → XP_011521576.1  dipeptidase 2 isoform X12

    Conserved Domains (1) summary
    cl00281
    Location:18 → 204
    metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

  4. XM_011523273.4 → XP_011521575.1  dipeptidase 2 isoform X10

    See identical proteins and their annotated locations for XP_011521575.1

    Conserved Domains (1) summary
    pfam01244
    Location:1 → 254
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

  5. XM_024450373.2 → XP_024306141.1  dipeptidase 2 isoform X1

    Conserved Domains (1) summary
    pfam01244
    Location:78 → 412
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

  6. XM_047434462.1 → XP_047290418.1  dipeptidase 2 isoform X6

  7. XM_024450374.2 → XP_024306142.1  dipeptidase 2 isoform X1

    Conserved Domains (1) summary
    pfam01244
    Location:78 → 412
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

  8. XM_047434461.1 → XP_047290417.1  dipeptidase 2 isoform X4

  9. XM_011523266.2 → XP_011521568.1  dipeptidase 2 isoform X1

    See identical proteins and their annotated locations for XP_011521568.1

    Conserved Domains (1) summary
    pfam01244
    Location:78 → 412
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

  10. XM_047434459.1 → XP_047290415.1  dipeptidase 2 isoform X1

  11. XM_017023545.2 → XP_016879034.1  dipeptidase 2 isoform X10

    Conserved Domains (1) summary
    pfam01244
    Location:1 → 254
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

  12. XM_047434460.1 → XP_047290416.1  dipeptidase 2 isoform X3

    UniProtKB/Swiss-Prot
    A0A024R6Y5, B2RCF8, B3KS59, I3L248, Q6UX92, Q8TC95, Q9H4A9

  13. XM_024450372.2 → XP_024306140.1  dipeptidase 2 isoform X1

    Conserved Domains (1) summary
    pfam01244
    Location:78 → 412
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

  14. XM_011523271.3 → XP_011521573.1  dipeptidase 2 isoform X8

    Conserved Domains (1) summary
    pfam01244
    Location:78 → 306
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

  15. XM_005256090.5 → XP_005256147.2  dipeptidase 2 isoform X5

    Conserved Domains (1) summary
    pfam01244
    Location:78 → 356
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

  16. XM_011523268.3 → XP_011521570.1  dipeptidase 2 isoform X2

    Conserved Domains (1) summary
    pfam01244
    Location:78 → 404
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)

  17. XM_047434464.1 → XP_047290420.1  dipeptidase 2 isoform X9

  18. XM_047434463.1 → XP_047290419.1  dipeptidase 2 isoform X7

  19. XM_047434465.1 → XP_047290421.1  dipeptidase 2 isoform X11

RNA

  1. XR_933392.4 RNA Sequence

  2. XR_243420.5 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    73783178..73796408 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054313624.1 → XP_054169599.1  dipeptidase 2 isoform X1

  2. XM_054313638.1 → XP_054169613.1  dipeptidase 2 isoform X12

  3. XM_054313640.1 → XP_054169615.1  dipeptidase 2 isoform X14

  4. XM_054313635.1 → XP_054169610.1  dipeptidase 2 isoform X10

  5. XM_054313639.1 → XP_054169614.1  dipeptidase 2 isoform X13

  6. XM_054313631.1 → XP_054169606.1  dipeptidase 2 isoform X6

  7. XM_054313625.1 → XP_054169600.1  dipeptidase 2 isoform X1

  8. XM_054313629.1 → XP_054169604.1  dipeptidase 2 isoform X4

  9. XM_054313626.1 → XP_054169601.1  dipeptidase 2 isoform X1

  10. XM_054313623.1 → XP_054169598.1  dipeptidase 2 isoform X1

  11. XM_054313636.1 → XP_054169611.1  dipeptidase 2 isoform X10

  12. XM_054313628.1 → XP_054169603.1  dipeptidase 2 isoform X3

    UniProtKB/Swiss-Prot
    A0A024R6Y5, B2RCF8, B3KS59, I3L248, Q6UX92, Q8TC95, Q9H4A9

  13. XM_054313622.1 → XP_054169597.1  dipeptidase 2 isoform X1

  14. XM_054313633.1 → XP_054169608.1  dipeptidase 2 isoform X8

  15. XM_054313630.1 → XP_054169605.1  dipeptidase 2 isoform X5

  16. XM_054313627.1 → XP_054169602.1  dipeptidase 2 isoform X2

  17. XM_054313634.1 → XP_054169609.1  dipeptidase 2 isoform X9

  18. XM_054313632.1 → XP_054169607.1  dipeptidase 2 isoform X7

  19. XM_054313637.1 → XP_054169612.1  dipeptidase 2 isoform X11

RNA

  1. XR_008484714.1 RNA Sequence

  2. XR_008484713.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H4A9.3 GenPept UniProtKB/Swiss-Prot:Q9H4A9

Gene LinkOut

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