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NPFFR1 neuropeptide FF receptor 1 [ Homo sapiens (human) ]

Gene ID: 64106, updated on 23-Nov-2021

Summary

Official Symbol
NPFFR1provided by HGNC
Official Full Name
neuropeptide FF receptor 1provided by HGNC
Primary source
HGNC:HGNC:17425
See related
Ensembl:ENSG00000148734 MIM:607448
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NPFF1; GPR147; NPFF1R1; OT7T022
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See NPFFR1 in Genome Data Viewer
Location:
10q22.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (70247329..70284004, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (72007085..72043760, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene inorganic pyrophosphatase 1 Neighboring gene H3K27me3-DHS negatively-acting regulatory element H2 Neighboring gene leucine rich repeat containing 20 Neighboring gene Sharpr-MPRA regulatory region 4423 Neighboring gene centrosomal protein 57 like 1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study identifies germline polymorphisms associated with relapse of childhood acute lymphoblastic leukemia.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10751

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G protein-coupled receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
enables neuropeptide receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
enables peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in biological_process ND
No biological Data available
more info
 
involved_in neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cilium IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
neuropeptide FF receptor 1
Names
G-protein coupled receptor 147
RFamide-related peptide receptor OT7T022
neuropeptide FF 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022146.5NP_071429.1  neuropeptide FF receptor 1

    See identical proteins and their annotated locations for NP_071429.1

    Status: VALIDATED

    Source sequence(s)
    AL355138, EU432128
    Consensus CDS
    CCDS53539.1
    UniProtKB/Swiss-Prot
    Q9GZQ6
    Related
    ENSP00000277942.5, ENST00000277942.7
    Conserved Domains (2) summary
    cd14964
    Location:4670
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:44340
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    70247329..70284004 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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