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POPDC2 popeye domain containing 2 [ Homo sapiens (human) ]

Gene ID: 64091, updated on 2-Mar-2021

Summary

Official Symbol
POPDC2provided by HGNC
Official Full Name
popeye domain containing 2provided by HGNC
Primary source
HGNC:HGNC:17648
See related
Ensembl:ENSG00000121577 MIM:605823
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
POP2
Summary
This gene encodes a member of the POP family of proteins which contain three putative transmembrane domains. This membrane associated protein is predominantly expressed in skeletal and cardiac muscle, and may have an important function in these tissues. [provided by RefSeq, Jul 2008]
Expression
Biased expression in heart (RPKM 152.4), urinary bladder (RPKM 12.2) and 2 other tissues See more
Orthologs
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Genomic context

See POPDC2 in Genome Data Viewer
Location:
3q13.33
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (119642056..119660589, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (119360903..119379436, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374062 Neighboring gene phospholipase A1 member A Neighboring gene ribosomal protein L10 pseudogene 7 Neighboring gene uncharacterized LOC105374063 Neighboring gene cytochrome c oxidase copper chaperone COX17 Neighboring gene uncharacterized LOC105374064

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cAMP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
heart development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of heart rate ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
skeletal muscle tissue development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
striated muscle cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
sarcolemma IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sarcolemma IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
popeye domain-containing protein 2
Names
popeye protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308333.2NP_001295262.1  popeye domain-containing protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC023494, AC073352
    Consensus CDS
    CCDS77797.1
    UniProtKB/Swiss-Prot
    Q9HBU9
    Related
    ENSP00000420715.1, ENST00000468801.1
    Conserved Domains (1) summary
    pfam04831
    Location:26251
    Popeye; Popeye protein conserved region
  2. NM_001369919.2NP_001356848.1  popeye domain-containing protein 2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC023494, AC073352
    Related
    ENSP00000417250.1, ENST00000493094.5
    Conserved Domains (1) summary
    pfam04831
    Location:26251
    Popeye; Popeye protein conserved region
  3. NM_022135.4NP_071418.2  popeye domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_071418.2

    Status: REVIEWED

    Source sequence(s)
    AC023494, AC073352
    Consensus CDS
    CCDS2992.1
    UniProtKB/Swiss-Prot
    Q9HBU9
    Related
    ENSP00000264231.3, ENST00000264231.7
    Conserved Domains (1) summary
    pfam04831
    Location:26251
    Popeye; Popeye protein conserved region

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    119642056..119660589 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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