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NEUROG2 neurogenin 2 [ Homo sapiens (human) ]

Gene ID: 63973, updated on 13-Mar-2020


Official Symbol
NEUROG2provided by HGNC
Official Full Name
neurogenin 2provided by HGNC
Primary source
See related
Ensembl:ENSG00000178403 MIM:606624
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NGN2; Atoh4; ngn-2; Math4A; bHLHa8
This gene encodes a neural-specific basic helix-loop-helix (bHLH) transcription factor that can specify a neuronal fate on ectodermal cells and is expressed in neural progenitor cells within the developing central and peripheral nervous systems. The protein product of this gene also plays a role in the differentiation and survival of midbrain dopaminergic neurons. [provided by RefSeq, Apr 2012]
Restricted expression toward testis (RPKM 1.1) See more

Genomic context

See NEUROG2 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (112513516..112516180, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (113434672..113437328, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986304 Neighboring gene TOX high mobility group box family member 4 pseudogene 1 Neighboring gene NEUROG2 and ZGRF1 antisense RNA 1 Neighboring gene VISTA enhancer hs981 Neighboring gene ribosomal protein L23a pseudogene 94

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into Functions

What's a GeneRIF?


Products Interactant Other Gene Complex Source Pubs Description

General gene information


Clone Names

  • MGC46562

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
E-box binding ISS
Inferred from Sequence or Structural Similarity
more info
protein dimerization activity IEA
Inferred from Electronic Annotation
more info
Process Evidence Code Pubs
neuron differentiation IEA
Inferred from Electronic Annotation
more info
positive regulation of DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
Component Evidence Code Pubs
nuclear chromatin ISA
Inferred from Sequence Alignment
more info

General protein information

Preferred Names
class A basic helix-loop-helix protein 8
protein atonal homolog 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024019.4NP_076924.1  neurogenin-2

    See identical proteins and their annotated locations for NP_076924.1

    Status: REVIEWED

    Source sequence(s)
    AC023886, BC036847
    Consensus CDS
    ENSP00000317333.3, ENST00000313341.4
    Conserved Domains (1) summary
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly


  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    112513516..112516180 complement
    GenBank, FASTA, Sequence Viewer (Graphics)
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