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GPSM3 G protein signaling modulator 3 [ Homo sapiens (human) ]

Gene ID: 63940, updated on 5-Aug-2022

Summary

Official Symbol
GPSM3provided by HGNC
Official Full Name
G protein signaling modulator 3provided by HGNC
Primary source
HGNC:HGNC:13945
See related
Ensembl:ENSG00000213654 MIM:618558; AllianceGenome:HGNC:13945
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
G18; NG1; AGS4; G18.2; C6orf9; G18.1a; G18.1b
Summary
Predicted to enable GTPase regulator activity. Predicted to be involved in positive regulation of inflammatory response. Predicted to act upstream of or within positive regulation of cytokine production involved in inflammatory response and positive regulation of leukocyte chemotaxis. Predicted to be located in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen (RPKM 56.7), lymph node (RPKM 55.9) and 21 other tissues See more
Orthologs
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Genomic context

See GPSM3 in Genome Data Viewer
Location:
6p21.32
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (32190766..32195523, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (32043955..32048712, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (32158543..32163300, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene advanced glycosylation end-product specific receptor Neighboring gene PBX homeobox 2 Neighboring gene notch receptor 4 Neighboring gene TSBP1 and BTNL2 antisense RNA 1 Neighboring gene testis expressed basic protein 1 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 2 Neighboring gene RNA, U6 small nuclear 603, pseudogene

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population.
EBI GWAS Catalog
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase regulator activity IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in positive regulation of cytokine production involved in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of leukocyte chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
G-protein-signaling modulator 3
Names
G-protein signaling modulator 3 (AGS3-like, C. elegans)
G-protein signalling modulator 3 (AGS3-like, C. elegans)
activator of G-protein signaling 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276501.2NP_001263430.1  G-protein-signaling modulator 3

    See identical proteins and their annotated locations for NP_001263430.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC018724, DA979033
    Consensus CDS
    CCDS34419.1
    UniProtKB/Swiss-Prot
    A2BFJ3, Q9Y4H4
    UniProtKB/TrEMBL
    A0A024RCP6
    Related
    ENSP00000364180.3, ENST00000375040.8
    Conserved Domains (1) summary
    smart00390
    Location:104126
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
  2. NM_022107.3NP_071390.1  G-protein-signaling modulator 3

    See identical proteins and their annotated locations for NP_071390.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AJ243937, AL662884
    Consensus CDS
    CCDS34419.1
    UniProtKB/Swiss-Prot
    A2BFJ3, Q9Y4H4
    UniProtKB/TrEMBL
    A0A024RCP6
    Related
    ENSP00000364183.3, ENST00000375043.3
    Conserved Domains (1) summary
    smart00390
    Location:104126
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    32190766..32195523 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_167244.2 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    3523365..3528122 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    3629115..3633872 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_4

Genomic

  1. NT_167246.2 Reference GRCh38.p14 ALT_REF_LOCI_4

    Range
    3495744..3500501 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_5

Genomic

  1. NT_167247.2 Reference GRCh38.p14 ALT_REF_LOCI_5

    Range
    3532782..3537539 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p14 ALT_REF_LOCI_6

    Range
    3413965..3418722 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_7

Genomic

  1. NT_167249.2 Reference GRCh38.p14 ALT_REF_LOCI_7

    Range
    3506971..3511728 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    32043955..32048712 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)