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GPSM3 G protein signaling modulator 3 [ Homo sapiens (human) ]

Gene ID: 63940, updated on 1-Jun-2020

Summary

Official Symbol
GPSM3provided by HGNC
Official Full Name
G protein signaling modulator 3provided by HGNC
Primary source
HGNC:HGNC:13945
See related
Ensembl:ENSG00000213654 MIM:618558
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
G18; NG1; AGS4; G18.2; C6orf9; G18.1a; G18.1b
Expression
Broad expression in spleen (RPKM 56.7), lymph node (RPKM 55.9) and 21 other tissues See more
Orthologs

Genomic context

See GPSM3 in Genome Data Viewer
Location:
6p21.32
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (32190766..32195523, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (32158543..32163300, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene advanced glycosylation end-product specific receptor Neighboring gene PBX homeobox 2 Neighboring gene notch receptor 4 Neighboring gene TSBP1 and BTNL2 antisense RNA 1 Neighboring gene testis expressed basic protein 1 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 2 Neighboring gene RNA, U6 small nuclear 603, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population.
NHGRI GWA Catalog
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase regulator activity IEA
Inferred from Electronic Annotation
more info
 
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
positive regulation of cytokine production involved in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
positive regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of leukocyte chemotaxis IEA
Inferred from Electronic Annotation
more info
 
regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
G-protein-signaling modulator 3
Names
G-protein signaling modulator 3 (AGS3-like, C. elegans)
G-protein signalling modulator 3 (AGS3-like, C. elegans)
activator of G-protein signaling 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276501.2NP_001263430.1  G-protein-signaling modulator 3

    See identical proteins and their annotated locations for NP_001263430.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC018724, DA979033
    Consensus CDS
    CCDS34419.1
    UniProtKB/Swiss-Prot
    Q9Y4H4
    UniProtKB/TrEMBL
    A0A024RCP6
    Related
    ENSP00000364180.3, ENST00000375040.8
    Conserved Domains (1) summary
    smart00390
    Location:104126
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
  2. NM_022107.2NP_071390.1  G-protein-signaling modulator 3

    See identical proteins and their annotated locations for NP_071390.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AJ243937, AL662884
    Consensus CDS
    CCDS34419.1
    UniProtKB/Swiss-Prot
    Q9Y4H4
    UniProtKB/TrEMBL
    A0A024RCP6
    Related
    ENSP00000364183.3, ENST00000375043.3
    Conserved Domains (1) summary
    smart00390
    Location:104126
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    32190766..32195523 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_167244.2 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    3523365..3528122 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p13 ALT_REF_LOCI_2

    Range
    3629115..3633872 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_4

Genomic

  1. NT_167246.2 Reference GRCh38.p13 ALT_REF_LOCI_4

    Range
    3495744..3500501 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_5

Genomic

  1. NT_167247.2 Reference GRCh38.p13 ALT_REF_LOCI_5

    Range
    3532782..3537539 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p13 ALT_REF_LOCI_6

    Range
    3413965..3418722 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_7

Genomic

  1. NT_167249.2 Reference GRCh38.p13 ALT_REF_LOCI_7

    Range
    3506971..3511728 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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